4xpj

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<StructureSection load='4xpj' size='340' side='right'caption='[[4xpj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4xpj' size='340' side='right'caption='[[4xpj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xpj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XPJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xpj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XPJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LPY:(2R)-2-HYDROXY-3-{[(S)-HYDROXY{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPYL+TRIDECANOATE'>LPY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.605&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpj OCA], [http://pdbe.org/4xpj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xpj RCSB], [http://www.ebi.ac.uk/pdbsum/4xpj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xpj ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LPY:(2R)-2-HYDROXY-3-{[(S)-HYDROXY{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPYL+TRIDECANOATE'>LPY</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xpj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xpj OCA], [https://pdbe.org/4xpj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xpj RCSB], [https://www.ebi.ac.uk/pdbsum/4xpj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xpj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NGF_MOUSE NGF_MOUSE]] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.
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[https://www.uniprot.org/uniprot/NGF_MOUSE NGF_MOUSE] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4xpj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4xpj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Nerve growth factor|Nerve growth factor]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Jiang, T]]
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[[Category: Jiang T]]
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[[Category: Sun, H L]]
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[[Category: Sun HL]]
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[[Category: Hormone]]
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[[Category: Lysopi]]
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[[Category: Nerve growth factor]]
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Current revision

Crystal structure of Nerve growth factor in complex with lysophosphatidylinositol

PDB ID 4xpj

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