This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4xz7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:03, 20 March 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='4xz7' size='340' side='right'caption='[[4xz7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4xz7' size='340' side='right'caption='[[4xz7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4xz7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43765 Atcc 43765]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XZ7 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4xz7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_suis Streptococcus suis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XZ7 FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xz7 OCA], [http://pdbe.org/4xz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xz7 RCSB], [http://www.ebi.ac.uk/pdbsum/4xz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xz7 ProSAT]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.101&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xz7 OCA], [https://pdbe.org/4xz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xz7 RCSB], [https://www.ebi.ac.uk/pdbsum/4xz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xz7 ProSAT]</span></td></tr>
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/A5JSJ3_STRSU A5JSJ3_STRSU]
-
Streptococcus suis serotype 2 (S. suis 2, Ss2) is an important swine and human zoonotic pathogen. In the present study, we identified a novel secreted immunogenic protein, SsTGase, contained a highly conserved eukaryotic-like transglutaminase (TGase) domain at the N terminus. We found that inactivation of SsTGase significantly reduced the virulence of Ss2 in a pig infection model and impaired its anti-phagocytosis in human blood. We further solved the crystal structure of the N-terminal portion of the protein in homodimer form at 2.1 A. Structure based mutagenesis and biochemical studies suggested that disruption of the homodimer directly resulted in the loss of its TGase activity and anti-phagocytic ability. Characterization of SsTGase as a novel virulence factor of Ss2 by acting as a TGase would be beneficial for developing new therapeutic agents against Ss2 infection.
+
-
 
+
-
Functional and structural characterization of the anti-phagocytic properties of a novel transglutaminase from Streptococcus suis.,Yu J, Pian Y, Ge J, Guo J, Zheng Y, Jiang H, Hao H, Yuan Y, Jiang Y, Yang M J Biol Chem. 2015 Jun 17. pii: jbc.M115.643338. PMID:26085092<ref>PMID:26085092</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 4xz7" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Atcc 43765]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Ge, J]]
+
[[Category: Streptococcus suis]]
-
[[Category: Yang, M]]
+
[[Category: Ge J]]
-
[[Category: Yu, J]]
+
[[Category: Yang M]]
-
[[Category: Anti-phacocytosis]]
+
[[Category: Yu J]]
-
[[Category: Homodimer]]
+
-
[[Category: Tgase acitivy]]
+
-
[[Category: Transferase]]
+
-
[[Category: Virulence factor]]
+

Current revision

Crystal structure of a TGase

PDB ID 4xz7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4xz7"
Personal tools