Dihydrofolate reductase 3D structures
From Proteopedia
(Difference between revisions)
(New page: == 3D Structures of Dihydrofolate reductase == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *DHFR **1ohk, [...) |
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**[[3f8y]], [[3f8z]], [[3f91]], [[3eig]], [[1dlr]], [[1dls]] – hDHFR (mutant) <br /> | **[[3f8y]], [[3f8z]], [[3f91]], [[3eig]], [[1dlr]], [[1dls]] – hDHFR (mutant) <br /> | ||
**[[3ia5]] – MpDHFR – ''Mritella profunda''<br /> | **[[3ia5]] – MpDHFR – ''Mritella profunda''<br /> | ||
| - | **[[2kgk]], [[2qk8]] – BaDHFR – ''Bacillus anthracis''<br /> | + | **[[2kgk]], [[2qk8]], [[8ssx]] – BaDHFR – ''Bacillus anthracis''<br /> |
**[[3dfr]] – LcDHFR – ''Lactobacillus casei''<br /> | **[[3dfr]] – LcDHFR – ''Lactobacillus casei''<br /> | ||
**[[2w9t]] – SaDHFR S1 - ''Staphylococcus aureus''<br /> | **[[2w9t]] – SaDHFR S1 - ''Staphylococcus aureus''<br /> | ||
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**[[1ai9]] – CaDHFR - ''Candida albicans''<br /> | **[[1ai9]] – CaDHFR - ''Candida albicans''<br /> | ||
**[[1cz3]], [[1d1g]] – DHFR – ''Thermotoga maritima''<br /> | **[[1cz3]], [[1d1g]] – DHFR – ''Thermotoga maritima''<br /> | ||
| - | **[[3q1h]], [[5fda]] – YpDHFR – ''Yersinia pestis''<br /> | + | **[[3q1h]], [[5fda]], [[8szd]] – YpDHFR – ''Yersinia pestis''<br /> |
**[[2l28]] – DHFR – ''Lactobacillus casei'' - NMR<BR /> | **[[2l28]] – DHFR – ''Lactobacillus casei'' - NMR<BR /> | ||
**[[3vco]] – DHFR – ''Schistosoma mansoni''<br /> | **[[3vco]] – DHFR – ''Schistosoma mansoni''<br /> | ||
| + | **[[8f09]] – DHFR – uncultured bacteria<br /> | ||
| + | **[[7rzo]] – SmDHFR – ''Stenotrophomonas maltophila''<br /> | ||
| + | **[[7zzx]] – CaDHFR - ''Candidozyma auris''<br /> | ||
*DHFR-Thymidine synthase (TS) complex | *DHFR-Thymidine synthase (TS) complex | ||
| + | **[[6pfi]] - hDHFR-TS + NADPH + dUMP + pyrimidine derivative <br /> | ||
| + | **[[8dae]] - DHFR-TS – ''Arabidopsis thaliana'' <br /> | ||
**[[3cl9]], [[2h2q]], [[3qfx]] – TcDHFR-TS - ''Trypanosoma cruzi''<br /> | **[[3cl9]], [[2h2q]], [[3qfx]] – TcDHFR-TS - ''Trypanosoma cruzi''<br /> | ||
**[[1qzf]] - ChTcDHFR-TS – ''Cryptosporidium hominis''<br /> | **[[1qzf]] - ChTcDHFR-TS – ''Cryptosporidium hominis''<br /> | ||
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**[[3kjs]], [[3rg9]] - TcDHFR-TS+NADPH +inhibitor<br /> | **[[3kjs]], [[3rg9]] - TcDHFR-TS+NADPH +inhibitor<br /> | ||
**[[3hbb]] – TcDHFR-TS+MTX & TMTX <br /> | **[[3hbb]] – TcDHFR-TS+MTX & TMTX <br /> | ||
| - | **[[3dg8]], [[1j3i]], [[3dga]], [[3qgt]], [[6a2k]], [[6a2m]], [[6a2o]] - PfDHFR-TS+NADPH +dUMP+inhibitor – ''Plasmodium falciparum''<br /> | + | **[[3dg8]], [[1j3i]], [[3dga]], [[3qgt]], [[6a2k]], [[6a2m]], [[6a2o]], [[7ctz]], [[7f3y]], [[7f3z]] - PfDHFR-TS+NADPH +dUMP+inhibitor – ''Plasmodium falciparum''<br /> |
| - | **[[1j3k]], [[1j3j]], [[3jsu]], [[6a2l]], [[6a2n]], [[6a2p]] - PfDHFR-TS (mutant)+NADPH+dUMP+ inhibitor<br /> | + | **[[1j3k]], [[1j3j]], [[3jsu]], [[6a2l]], [[6a2n]], [[6a2p]], [[8jfb]], [[8jfc]], [[8wgm]], [[8wgn]], [[8yq8]], [[8yq9]] - PfDHFR-TS (mutant)+NADPH+dUMP+ inhibitor<br /> |
| - | **[[ | + | **[[7ctw]], [[7cty]] - PfDHFR-TS +NADPH+ inhibitor<br /> |
| - | **[[ | + | **[[3qg2]], [[6leu]], [[6lev]], [[6lez]], [[6lh9]], [[6lhi]], [[6lhj]], [[8jfd]] - PfDHFR-TS (mutant)+NADPH + inhibitor<br /> |
| - | **[[ | + | **[[3um8]], [[4dph]], [[6kot]] - PfDHFR-TS + NADPH + anti-malarial drug<br /> |
| + | **[[3um5]], [[3um6]], [[4dp3]], [[6kp2]], [[6kp7]], [[6kpr]] - PfDHFR-TS (mutant)+NADPH + dUMP + anti-malarial drug<br /> | ||
**[[4dpd]] - PfDHFR-TS +NADPH + dUMP + folate<br /> | **[[4dpd]] - PfDHFR-TS +NADPH + dUMP + folate<br /> | ||
**[[3k2h]], [[3nrr]] - BbDHFR-TS+NADPH+dUMP+inhibitor<br /> | **[[3k2h]], [[3nrr]] - BbDHFR-TS+NADPH+dUMP+inhibitor<br /> | ||
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**[[4ky4]], [[4kya]] - TgDHFR-TS + NADPH + dUMP + aminopterin<br /> | **[[4ky4]], [[4kya]] - TgDHFR-TS + NADPH + dUMP + aminopterin<br /> | ||
**[[5t0l]], [[6n1t]] - TgDHFR-TS + NADPH + dUMP + folate derivative + inhibitor<br /> | **[[5t0l]], [[6n1t]] - TgDHFR-TS + NADPH + dUMP + folate derivative + inhibitor<br /> | ||
| + | **[[7fgw]], [[7fgx]], [[7fgy]] - TgDHFR-TS + NADPH + dUMP + inhibitor<br /> | ||
**[[3hj3]] - ChDHFR-TS + NADPH + dUMP + MTX <br /> | **[[3hj3]] - ChDHFR-TS + NADPH + dUMP + MTX <br /> | ||
| - | **[[4ky8]], [[4q0d]], [[4q0e]] - ChDHFR-TS + NADPH + dUMP + MTX + pyrimidine derivative <br /> | + | **[[4ky8]], [[4q0d]], [[4q0e]], [[6ojs]], [[6pf7]], [[6pf8]], [[6pf9]], [[6pfa]], [[6pfb]], [[6pfc]], [[6pfd]], [[6pfe]], [[6pff]], [[6pfg]], [[6pfh]], [[6pfi]] - ChDHFR-TS + NADPH + dUMP + MTX + pyrimidine derivative <br /> |
**[[6aog]], [[6aoh]], [[6aoi]] - TgDHFR-TS + NADPH + dUMP + folate derivative + inhibitor<br /> | **[[6aog]], [[6aoh]], [[6aoi]] - TgDHFR-TS + NADPH + dUMP + folate derivative + inhibitor<br /> | ||
**[[6n1s]] - TgDHFR-TS (mutant) + NADPH + dUMP + folate derivative + inhibitor<br /> | **[[6n1s]] - TgDHFR-TS (mutant) + NADPH + dUMP + folate derivative + inhibitor<br /> | ||
**[[1e26]] - PcDHFR-TS+NADP+folate - ''Plasmodium carinii''<br /> | **[[1e26]] - PcDHFR-TS+NADP+folate - ''Plasmodium carinii''<br /> | ||
**[[1qzf]] - ChTcDHFR-TS – ''Cryptosporidium hominis''<br /> | **[[1qzf]] - ChTcDHFR-TS – ''Cryptosporidium hominis''<br /> | ||
| - | **[[3dl5]], [[3dl6, [[2oip – ChDHFR-TS (mutant) <br /> | + | **[[3dl5]], [[3dl6]], [[2oip]] – ChDHFR-TS (mutant) <br /> |
**[[3hj3]] - ChDHFR-TS + NADPH + dUMP + MTX <br /> | **[[3hj3]] - ChDHFR-TS + NADPH + dUMP + MTX <br /> | ||
**[[4ky8]], [[4q0d]], [[4q0e]] - ChDHFR-TS + NADPH + dUMP + MTX + pyrimidine derivative <br /> | **[[4ky8]], [[4q0d]], [[4q0e]] - ChDHFR-TS + NADPH + dUMP + MTX + pyrimidine derivative <br /> | ||
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**[[1s3u]], [[1s3v]], [[1s3w]] – hDHFR+tetrahydroauinazoline<br /> | **[[1s3u]], [[1s3v]], [[1s3w]] – hDHFR+tetrahydroauinazoline<br /> | ||
| - | **[[1mvs]], [[1mvt]], [[1pd8]], [[1pd9]], [[1pdb]], [[1mvs]], [[1mvt]], [[3fs6]], [[1hfp]], [[1hfq]], [[1hfr]], [[2c2s]], [[2c2t]], [[2w3b]], [[3gyf]], [[3nxo]], [[3nxr]], [[3nxt]], [[3nxv]], [[3nu0]], [[4g95]] – hDHFR+pyrimidine derivatives<br /> | + | **[[1mvs]], [[1mvt]], [[1pd8]], [[1pd9]], [[1pdb]], [[1mvs]], [[1mvt]], [[3fs6]], [[1hfp]], [[1hfq]], [[1hfr]], [[2c2s]], [[2c2t]], [[2w3b]], [[3gyf]], [[3nxo]], [[3nxr]], [[3nxt]], [[3nxv]], [[3nu0]], [[4g95]], [[7xi7]] – hDHFR+pyrimidine derivatives<br /> |
**[[3s7a]] - hDHFR+ inhibitor<br /> | **[[3s7a]] - hDHFR+ inhibitor<br /> | ||
**[[3l3r]], [[3gi2]], [[3ghc]], [[3ghv]], [[3ghw]], [[3oaf]] – hDHFR (mutant)+pyrimidine derivatives<br /> | **[[3l3r]], [[3gi2]], [[3ghc]], [[3ghv]], [[3ghw]], [[3oaf]] – hDHFR (mutant)+pyrimidine derivatives<br /> | ||
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**[[1dra]], [[1drb]], [[2drc]], [[3drc]], [[1dds]], [[4dfr]] - EcDHFR+MTX<br /> | **[[1dra]], [[1drb]], [[2drc]], [[3drc]], [[1dds]], [[4dfr]] - EcDHFR+MTX<br /> | ||
**[[2inq]] – EcDHFR+MTX – neutron diffraction<br /> | **[[2inq]] – EcDHFR+MTX – neutron diffraction<br /> | ||
| - | **[[1rx5]], [[3och]], [[6cqa]], [[6nxz]], [[6ny0]] - EcDHFR+ inhibitor<br /> | + | **[[1rx5]], [[3och]], [[6cqa]], [[6nxz]], [[6ny0]], [[7f3b]], [[7mqp]], [[7reb]] - EcDHFR+ inhibitor<br /> |
| + | **[[7nae]] – EcDHFR + TMP<br /> | ||
| + | **[[9daq]], [[9dar]] – EcDHFR + cycloguanil<br /> | ||
| + | **[[9cum]] – EcDHFR (mutant) + congo red<br /> | ||
**[[4eig]], [[4eiz]] – EcDHFR + antibody fragment<br /> | **[[4eig]], [[4eiz]] – EcDHFR + antibody fragment<br /> | ||
**[[2cig]] – MtDHFR+isoniazid derivative – ''Mycobacterium tuberculosis''<br /> | **[[2cig]] – MtDHFR+isoniazid derivative – ''Mycobacterium tuberculosis''<br /> | ||
**[[4klx]] - MtDHFR + ADP<br /> | **[[4klx]] - MtDHFR + ADP<br /> | ||
| - | **[[3tq8]] - CbDHFR+TMP – ''Coxiella burnetii''<br /> | + | **[[6vs5]] - MtDHFR + pyrazole derivative<br /> |
| + | **[[8cop]], [[8cow]], [[8cox]] – MtDHFR+pyrimidine derivative | ||
| + | **[[3tq8]] - CbDHFR + TMP – ''Coxiella burnetii''<br /> | ||
**[[3tq9]] – CbDHFR + MTX<br /> | **[[3tq9]] – CbDHFR + MTX<br /> | ||
**[[4qi9]], [[5hi6]] - YpDHFR + MTX <br /> | **[[4qi9]], [[5hi6]] - YpDHFR + MTX <br /> | ||
| - | + | **[[8sze]] - YpDHFR + TMP <br /> | |
| + | **[[7myl]] - KpDHFR + TMP <br /> | ||
| + | **[[7l9t]] - MsDHFR + pyrimidine derivative – ''Mycobacterium smegmatis''<br /> | ||
| + | |||
*''Ternary complexes with pyrimidine derivative'' | *''Ternary complexes with pyrimidine derivative'' | ||
| - | **[[4ddr]], [[4kak]], [[4kbn]], [[4kd7]], [[4keb]], [[4kfj]], [[4qhv]], [[4qjc]], [[5hpb]], [[5hqy]], [[5hqz]], [[5hsr]], [[5hsu]], [[5ht4]], [[5ht5]], [[5hui]], [[5hvb]], [[5hve]], [[1kms]], [[1kmv]], [[3ntz]], [[3nxx]], [[3nxy]], [[6a7c]], [[6a7e]], [[6de4]] – hDHFR + NADPH + pyrimidine inhibitor<br /> | + | **[[4ddr]], [[4kak]], [[4kbn]], [[4kd7]], [[4keb]], [[4kfj]], [[4qhv]], [[4qjc]], [[5hpb]], [[5hqy]], [[5hqz]], [[5hsr]], [[5hsu]], [[5ht4]], [[5ht5]], [[5hui]], [[5hvb]], [[5hve]], [[1kms]], [[1kmv]], [[3ntz]], [[3nxx]], [[3nxy]], [[6a7c]], [[6a7e]], [[6de4]], [[7reg]], [[7rgj]], [[7rgk]] – hDHFR + NADPH + pyrimidine inhibitor<br /> |
| - | **[[3sgy]], [[3sh2]], [[4tu5]], [[4xe6]], [[4xec]], [[5hf0]], [[5hf2]], [[5jg0]], [[6e4e]] - SaDHFR +NADP+ pyrimidine derivative<br /> | + | **[[3sgy]], [[3sh2]], [[4tu5]], [[4xe6]], [[4xec]], [[5hf0]], [[5hf2]], [[5jg0]], [[6e4e]], [[6nd2]], [[6pbo]], [[7t7q]], [[7t7s]] - SaDHFR +NADP+ pyrimidine derivative<br /> |
**[[3i8a]], [[3f0q]], [[3f0s]], [[3f0v]], [[3f0x]], [[3f0b]], [[3f0u]], [[3fq0]], [[3fqc]], [[3fqf]], [[3fqo]], [[3fqv]], [[3fqz]], [[3lg4]], [[5isp]], [[5isq]], [[5ist]] – SaDHFR (mutant)+NADPH+ pyrimidine derivative<br /> | **[[3i8a]], [[3f0q]], [[3f0s]], [[3f0v]], [[3f0x]], [[3f0b]], [[3f0u]], [[3fq0]], [[3fqc]], [[3fqf]], [[3fqo]], [[3fqv]], [[3fqz]], [[3lg4]], [[5isp]], [[5isq]], [[5ist]] – SaDHFR (mutant)+NADPH+ pyrimidine derivative<br /> | ||
**[[2w3w]] – MaDHFR+NADPH+ pyrimidine derivative<br /> | **[[2w3w]] – MaDHFR+NADPH+ pyrimidine derivative<br /> | ||
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**[[4h95]], [[4h96]], [[4h97]], [[4hoe]], [[4hof]] - CaDHFR + NADPH + pyrimidine derivative<br /> | **[[4h95]], [[4h96]], [[4h97]], [[4hoe]], [[4hof]] - CaDHFR + NADPH + pyrimidine derivative<br /> | ||
**[[4km0]] – MtDHFR + ADP + pyrimidine derivative<br /> | **[[4km0]] – MtDHFR + ADP + pyrimidine derivative<br /> | ||
| - | **[[5ja3]], [[5u26]], [[5u27]], [[5ujf]], [[6ddp]], [[6dds]], [[6ddw]] – MtDHFR + NADP + pyrimidine derivative<br /> | + | **[[5ja3]], [[5scd]], [[5scm]], [[5scn]], [[5sco]], [[5scp]], [[5scq]], [[5scr]], [[5sct]], [[5scu]], [[5scv]], [[5scw]], [[5scx]], [[5scy]], [[5scz]], [[5sd0]], [[5sd1]], [[5sd2]], [[5sd3]], [[5sd4]], [[5sd5]], [[5sd6]], [[5sd7]], [[5sd8]], [[5sd9]], [[5sda]], 5sdb]], [[5u26]], [[5u27]], [[5ujf]], [[6ddp]], [[6dds]], [[6ddw]], [[6nnc]], [[6nne]], [[8coq]] – MtDHFR + NADP + pyrimidine derivative<br /> |
**[[3nza]] - PncDHFR+NADPH+ pyrimidine derivative<br /> | **[[3nza]] - PncDHFR+NADPH+ pyrimidine derivative<br /> | ||
**[[4m7v]] - EfDHFR +NADPH + pyrimidine derivative - ''Enterococcus faecalis'' <br /> | **[[4m7v]] - EfDHFR +NADPH + pyrimidine derivative - ''Enterococcus faecalis'' <br /> | ||
**[[4or7]], [[4osg]], [[5ecc]], [[5ecx]] - DHFR +NADPH + pyrimidine derivative – ''Klebsiella pneumoniae'' <br /> | **[[4or7]], [[4osg]], [[5ecc]], [[5ecx]] - DHFR +NADPH + pyrimidine derivative – ''Klebsiella pneumoniae'' <br /> | ||
**[[6cxm]] - MsDHFR +NADPH + pyrimidine derivative – ''Mycobacterium smegmatis''<br /> | **[[6cxm]] - MsDHFR +NADPH + pyrimidine derivative – ''Mycobacterium smegmatis''<br /> | ||
| + | **[[7k6c]] – DHFR (mutant) + NADPH + pyrimidine derivative –'' Mycobacterioides abscessus''<br /> | ||
| + | **[[6uwq]], [[6uww]], [[7k69]], [[7k6a]], [[7kac]], [[7ki8]], [[7ki9]], [[7km7]], [[7km8]], [[7ka9]], [[8cq8]], [[8cq9]], [[8cqa]] – MuDHFR + NADPH + pyrimidine derivative – Mycobacterium ulcerans<br /> | ||
| + | **[[7k68]], [[7k6a]], [[8f80]], [[8f81]], [[8f82]], [[8f83]], [[8f84]], [[8f85]], [[8ta0]], [[8ta1]], [[8tbr]] – MuDHFR (mutant) + NADPH + pyrimidine derivative <br /> | ||
| + | **[[7rgo]] – EcDHFR + NADPH + pyrimidine derivative <br /> | ||
| + | **[[7tj3]] – SmDHFR + NADPH + pyrimidine derivative <br /> | ||
| + | **[[8a0z]] – CaDHFR + NADPH + pyrimidine derivative <br /> | ||
| + | **[[8crh]] – CaDHFR + NADPH + cycloguanil<br /> | ||
*''Ternary complexes with quinazoline derivative'' | *''Ternary complexes with quinazoline derivative'' | ||
| + | **[[1boz]] – hDHFR (mutant)+NADPH+quinazoline derivative<br /> | ||
**[[4lae]], [[4lag]], [[4lah]], [[4lek]] - SaDHFR +NADPH+ quinazoline derivative<br /> | **[[4lae]], [[4lag]], [[4lah]], [[4lek]] - SaDHFR +NADPH+ quinazoline derivative<br /> | ||
**[[3qyl]], [[3qyo]], [[3r33]], [[3kfy]] - EcDHFR +NADPH+quinazoline derivative<br /> | **[[3qyl]], [[3qyo]], [[3r33]], [[3kfy]] - EcDHFR +NADPH+quinazoline derivative<br /> | ||
**[[1ly3]], [[1s3y]] – PcDHFR +NAP+quinazoline derivative<br /> | **[[1ly3]], [[1s3y]] – PcDHFR +NAP+quinazoline derivative<br /> | ||
| - | **[[1boz]] – hDHFR (mutant)+NADPH+quinazoline derivative<br /> | ||
**[[1m79]], [[1m78]], [[1m7a]], [[1ia1]], [[1ia2]], [[1ia3]], [[1ia4]], [[1aoe]] – CaDHFR+NADPH+quinazoline derivative <br /> | **[[1m79]], [[1m78]], [[1m7a]], [[1ia1]], [[1ia2]], [[1ia3]], [[1ia4]], [[1aoe]] – CaDHFR+NADPH+quinazoline derivative <br /> | ||
**[[1sej]] - ChDHFR +NADPH+quinazoline derivative+deoxyuridine <br /> | **[[1sej]] - ChDHFR +NADPH+quinazoline derivative+deoxyuridine <br /> | ||
| + | **[[6dtc]] – DHFR +NADPH+quinazoline derivative – ''Aspergillus flavus''<br /> | ||
*''Ternary complexes with TMP'' | *''Ternary complexes with TMP'' | ||
| + | **[[2w3a]] – hDHFR +TMP+NADPH<BR /> | ||
| + | **[[1yho]] - hDHFR+NADPH+ TMP – NMR<BR /> | ||
| + | **[[2fzi]], [[2fzj]] - mDHFR+NADPH+ TMP<br /> | ||
**[[2w9g]] - SaDHFR+ TMP +NADPH<BR /> | **[[2w9g]] - SaDHFR+ TMP +NADPH<BR /> | ||
**[[3fre]], [[2w9s]], [[3frb]] – SaDHFR (mutant)+TMP+NADPH<BR /> | **[[3fre]], [[2w9s]], [[3frb]] – SaDHFR (mutant)+TMP+NADPH<BR /> | ||
**[[4g8z]] - DHFR (mutant)+TMP+NADPH – ''Pneumocystis jirovecii''<br /> | **[[4g8z]] - DHFR (mutant)+TMP+NADPH – ''Pneumocystis jirovecii''<br /> | ||
| - | **[[2w3v]] – MaDHFR +TMP+NADPH – ''Mycobacterium avium''<br /> | + | **[[2w3v]], [[8vtc]] – MaDHFR +TMP+NADPH – ''Mycobacterium avium''<br /> |
**[[3jw3]], [[3jw5]] – BaDHFR (mutant)+ TMP +NADPH<BR /> | **[[3jw3]], [[3jw5]] – BaDHFR (mutant)+ TMP +NADPH<BR /> | ||
**[[3s9u]], [[3sa1]], [[3sa2]], [[3sai]] – BaDHFR (mutant) +TMP analog + NADP<br /> | **[[3s9u]], [[3sa1]], [[3sa2]], [[3sai]] – BaDHFR (mutant) +TMP analog + NADP<br /> | ||
**[[1lud]] - LcDHFR+NADPH+ TMP – NMR<BR /> | **[[1lud]] - LcDHFR+NADPH+ TMP – NMR<BR /> | ||
| - | + | **[[2fzh]] – PcDHFR+NADPH+ TMP <br /> | |
| - | **[[2fzh]] – PcDHFR+NADPH+ TMP <br | + | |
| - | + | ||
| - | + | ||
**[[1dg5]] - MtDHFR + TMP +NADPH<BR /> | **[[1dg5]] - MtDHFR + TMP +NADPH<BR /> | ||
**[[4km2]] - MtDHFR + ADP + TMP<br /> | **[[4km2]] - MtDHFR + ADP + TMP<br /> | ||
| + | **[[6xg4]], [[6xg5]], [[7mym]], [[7r6g]], [[9kz4]] - EcDHFR+NADPH+ TMP<br /> | ||
*''Ternary complexes with MTX'' | *''Ternary complexes with MTX'' | ||
| + | **[[1u71]], [[1u72]] - hDHFR (mutant)+MTX+NADPH<BR /> | ||
| + | **[[1u70]] – mDHFR (mutant)+MTX+NADPH<BR /> | ||
**[[3ia4]] – MpDHFR+ MTX +NADPH<BR /> | **[[3ia4]] – MpDHFR+ MTX +NADPH<BR /> | ||
| - | **[[3dat]] - | + | **[[3dat]] - BaDHFR+ MTX+NADPH<BR /> |
**[[1bzf]] - LcDHFR+NADPH+ TMX – NMR<BR /> | **[[1bzf]] - LcDHFR+NADPH+ TMX – NMR<BR /> | ||
| - | **[[1u70]] – mDHFR (mutant)+MTX+NADPH<BR /> | ||
**[[1dre]], [[1rb3]], [[1rg7]], [[1rh3]], [[1ra3]], [[1rx3]], [[3dau]], [[4gh8]] - EcDHFR+NADP+MTX<br /> | **[[1dre]], [[1rb3]], [[1rg7]], [[1rh3]], [[1ra3]], [[1rx3]], [[3dau]], [[4gh8]] - EcDHFR+NADP+MTX<br /> | ||
**[[1ddr]] - EcDHFR+MTX+urea<br /> | **[[1ddr]] - EcDHFR+MTX+urea<br /> | ||
| - | **[[1tdr]] - EcDHFR+MTX+Te<br /> | + | **[[1tdr]] - EcDHFR+MTX+Te<br /> |
| - | **[[ | + | **[[6p9z]], [[6wep]] - SaDHFR +MTX+NADPH<BR /> |
**[[1df7]] - MtDHFR +MTX+NADPH<BR /> | **[[1df7]] - MtDHFR +MTX+NADPH<BR /> | ||
**[[3ix9]] – DHFR (mutant) +MTX+NADPH – ''Streptococcus pneumoniae''<br /> | **[[3ix9]] – DHFR (mutant) +MTX+NADPH – ''Streptococcus pneumoniae''<br /> | ||
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*''Other ternary complexes '' | *''Other ternary complexes '' | ||
| + | **[[3k45]], [[3k47]] – mDHFR+E & Z-isomer+NADPH – mouse<br /> | ||
| + | **[[3d80]], [[3d84]] – mDHFR+NADPH+ pteridin derivative<br /> | ||
| + | **[[1klk]] – DHFR+NADPH+PT653 – rat<br /> | ||
| + | **[[1dr1]], [[1dr2]], [[1dr3]] - cDHFR+NADP+biopterin – chicken<br /> | ||
| + | **[[1dr4]], [[1dr5]], [[1dr6]], [[1dr7]] - cDHFR+NADP+biopterin+Hg<br /> | ||
**[[3m08]] - SaDHFR+RAB1+NADP<br /> | **[[3m08]] - SaDHFR+RAB1+NADP<br /> | ||
**[[3m09]] – SaDHFR (mutant)+RAB1+NADP<br > | **[[3m09]] – SaDHFR (mutant)+RAB1+NADP<br > | ||
| Line 154: | Line 184: | ||
**[[3fyv]] – SaDHFR (mutant)+ AR-102+NADPH<BR /> | **[[3fyv]] – SaDHFR (mutant)+ AR-102+NADPH<BR /> | ||
**[[3fyw]] – SaDHFR + AR-101+NADPH<BR /> | **[[3fyw]] – SaDHFR + AR-101+NADPH<BR /> | ||
| - | **[[3frf ]]– SaDHFR (mutant)+iclaprim+NADPH<BR /> | + | **[[3frf]] – SaDHFR (mutant)+iclaprim+NADPH<BR /> |
| - | **[[ | + | **[[6pr6]], [[6pr7]], [[6pr8]], [[6pr9]], [[6prb]], [[6prd]] – SaDHFR + phthalazine derivative +NADPH<BR /> |
| - | + | ||
**[[2ano]], [[2anq]] - EcDHFR+NADPH+MS-SH08-17<br /> | **[[2ano]], [[2anq]] - EcDHFR+NADPH+MS-SH08-17<br /> | ||
**[[5uih]] - EcDHFR+NADP + drug<br /> | **[[5uih]] - EcDHFR+NADP + drug<br /> | ||
| Line 162: | Line 191: | ||
**[[1vj3]] – PcHDFR+TAB+NADPH <br /> | **[[1vj3]] – PcHDFR+TAB+NADPH <br /> | ||
**[[4m2x]] - MtDHFR + trimetrexate +NADPH<br /> | **[[4m2x]] - MtDHFR + trimetrexate +NADPH<br /> | ||
| + | **[[6nnh]] - MtDHFR + cycloguanyl +NADPH<br /> | ||
| + | **[[6nni]] - MtDHFR + pyrimethamine +NADPH<br /> | ||
**[[4kne]] - MtDHFR + ADP + anti-folate drug<br /> | **[[4kne]] - MtDHFR + ADP + anti-folate drug<br /> | ||
**[[1dg7]] - MtDHFR + 4-Br-WR99210 +NADPH<BR /> | **[[1dg7]] - MtDHFR + 4-Br-WR99210 +NADPH<BR /> | ||
| - | **[[ | + | **[[6vs6]], [[6vs8]], [[6vs9]], [[6vsb]], [[6vsd]], [[6vse]], [[6vsf]], [[6vsg]], [[6vv6]], [[6vv7]], [[6vv9]], [[6vvb]] - MtDHFR + inhibitor +NADPH<BR /> |
| - | + | **[[8rht]] - DHFR + inhibitor + NADPH – ''Trypanosoma brucei''<BR /> | |
| - | **[[ | + | |
*DHFR higher complexes | *DHFR higher complexes | ||
| Line 172: | Line 202: | ||
**[[5uio]] - EcDHFR + pyrimidine diamine +NADPH + monophosphateadenosine diphosphoribose + aminobenzyl carbonyl glutamate<br /> | **[[5uio]] - EcDHFR + pyrimidine diamine +NADPH + monophosphateadenosine diphosphoribose + aminobenzyl carbonyl glutamate<br /> | ||
**[[5uip]] - EcDHFR (mutant) + pyrimidine diamine +NADPH + monophosphateadenosine diphosphoribose + aminobenzyl carbonyl glutamate<br /> | **[[5uip]] - EcDHFR (mutant) + pyrimidine diamine +NADPH + monophosphateadenosine diphosphoribose + aminobenzyl carbonyl glutamate<br /> | ||
| + | **[[8v9r]], [[9c87]] - EcDHFR + ClpXP + ADP + ATP + MTX – Cryo EM | ||
*DHFR+ligands | *DHFR+ligands | ||
| - | **[[2w3m]], [[4m6k]], [[6dav]] – hDHFR +folate+NADPH<BR /> | + | **[[2w3m]], [[4m6k]], [[6dav]], [[7ese]] – hDHFR +folate+NADPH<BR /> |
**[[1drf]] - hDHFR +folate<br /> | **[[1drf]] - hDHFR +folate<br /> | ||
**[[1dhf]], [[2dhf]] – hDHFR+folate+5-deazofolate<br /> | **[[1dhf]], [[2dhf]] – hDHFR+folate+5-deazofolate<br /> | ||
**[[4m6l]] - hDHFR+folate+ NADPH + folate derivative<br /> | **[[4m6l]] - hDHFR+folate+ NADPH + folate derivative<br /> | ||
| + | **[[6vcj]] - hDHFR+folate+ NADPH + pyrimidine derivative + drug<br /> | ||
**[[1e26]] - PcDHFR-TS+NADP+folate<br /> | **[[1e26]] - PcDHFR-TS+NADP+folate<br /> | ||
**[[2jyb]] – HvDHFR+folate<br /> | **[[2jyb]] – HvDHFR+folate<br /> | ||
| + | **[[8e4f]] - DHFR+folate+ NADPH – ''Wuhereria bancrofti''<br /> | ||
| + | **[[8ucx]] – EcDHFR + folate <br /> | ||
**[[2rk1]] – EcDHFR+NADP+dihydrofolate<br /> | **[[2rk1]] – EcDHFR+NADP+dihydrofolate<br /> | ||
**[[7dfr]] - EcDHFR+NAP+NADP+folate<br /> | **[[7dfr]] - EcDHFR+NAP+NADP+folate<br /> | ||
**[[1ra8]], [[1rx8]], [[1rx4]] – EcDHFR+folate+ ADP derivative<br /> | **[[1ra8]], [[1rx8]], [[1rx4]] – EcDHFR+folate+ ADP derivative<br /> | ||
| - | **[[1rb2]], [[1rx2]], [[1ra2]], [[3ql3]], [[4kjj]], [[4kjk]], [[4nx6]], [[4nx7]], [[4pss]], [[4pst]], [[4psy]], [[4pth]], [[4ptj]], [[4rgc]], [[4x5f]], [[4x5g]], [[4x5h]], [[4x5i]], [[4x5j]], [[ | + | **[[1dyl]], [[1rb2]], [[1rx2]], [[1ra2]], [[3ql3]], [[4kjj]], [[4kjk]], [[4nx6]], [[4nx7]], [[4pss]], [[4pst]], [[4psy]], [[4pth]], [[4ptj]], [[4rgc]], [[4x5f]], [[4x5g]], [[4x5h]], [[4x5i]], [[4x5j]], [[5sss]], [[5sst]], [[5ssu]], [[5ssv]], [[[5ssw]], [7d3z]], [[7d49]], [[7d4l]], [[7d4x]], [[7d6g]], [[7fpl]], [[7fpm]], [[7fpn]], [[7fpo]], [[7fpp]], [[7fpq]], [[7fpr]], [[7fps]], [[7fpt]], [[7fpu]], [[7fpv]], [[7fpw]], [[7fpx]], [[7fpy]], [[7fpz]], [[7fq0]], [[7fq1]], [[7fq2]], [[7fq3]], [[7fq4]], [[7fq5]], [[7fq6]], [[7fq7]], [[7fq8]], [[7fq9]], [[7fqa]], [[7fqb]], [[7fqc]], [[7fqd]], [[7fqe]], [[7fqf]], [[7fqg]], [[7lvc]], [[8g50]], [[8uw0]] - EcDHFR+folate+NADP |
**[[4pdj]] - EcDHFR+folate+NADP – Neutron<br /> | **[[4pdj]] - EcDHFR+folate+NADP – Neutron<br /> | ||
| - | **[[ | + | **[[8g4z]] - EcDHFR+folate+NADP – Laue<br /> |
| + | **[[1dyh]], [[1dyj]], [[1rc4]], [[1rx6]], [[5cc9]], [[5ccc]], [[6cyv]], [[8dai]] - EcDHFR+folate derivative +NADP <br /> | ||
**[[3ql0]], [[4kjl]], [[4qle]], [[4qlf]], [[4qlg]] – EcDHFR (mutant) +folate+NADP<br /> | **[[3ql0]], [[4kjl]], [[4qle]], [[4qlf]], [[4qlg]] – EcDHFR (mutant) +folate+NADP<br /> | ||
**[[1rx7]], [[1rd7]], [[1re7]], [[5e8q]], [[5eaj]],[[1dyi]], [[1rf7]], [[6cw7]], [[6cxk]], [[1jol]], [[1jom]], [[6mr9]] - EcDHFR+folate derivative<br /> | **[[1rx7]], [[1rd7]], [[1re7]], [[5e8q]], [[5eaj]],[[1dyi]], [[1rf7]], [[6cw7]], [[6cxk]], [[1jol]], [[1jom]], [[6mr9]] - EcDHFR+folate derivative<br /> | ||
| Line 195: | Line 230: | ||
**[[1cd2]] - PcHDFR+folate+NADPH<BR /> | **[[1cd2]] - PcHDFR+folate+NADPH<BR /> | ||
**[[2zza]] – MpDHFR+ folate +NADP<br /> | **[[2zza]] – MpDHFR+ folate +NADP<br /> | ||
| + | **[[8uvz]] - DHFR+ folate +NADP – ''Bacillus subtilis'' | ||
**[[3tqb]] – CbDHFR + NADPH + folate<br /> | **[[3tqb]] – CbDHFR + NADPH + folate<br /> | ||
**[[3frd]] – SaDHFR (mutant)+folate +NADP<br /> | **[[3frd]] – SaDHFR (mutant)+folate +NADP<br /> | ||
| + | **[[6nnd]] - MtDHFR + DHF +NADPH<br /> | ||
*DHFR+co-factors | *DHFR+co-factors | ||
| + | **[[4m6j]] - hDHFR +NADPH<br /> | ||
| + | **[[8dfr]] - cDHFR +NADPH<BR /> | ||
**[[2hqp]], [[2lf1]] – LcDHFR+NADPH – NMR<BR /> | **[[2hqp]], [[2lf1]] – LcDHFR+NADPH – NMR<BR /> | ||
**[[2rk2]], [[2p4t]], [[1ra9]], [[1rx9]] – EcDHFR+NADP<br /> | **[[2rk2]], [[2p4t]], [[1ra9]], [[1rx9]] – EcDHFR+NADP<br /> | ||
**[[1rx1]], [[1ra1]] - EcDHFR+NADPH<BR /> | **[[1rx1]], [[1ra1]] - EcDHFR+NADPH<BR /> | ||
| - | **[[5w3q]] - EcDHFR (mutant) +NADPH <br /> | + | **[[5w3q]], [[8vz4]] - EcDHFR (mutant) +NADPH <br /> |
**[[6dfr]] - EcDHFR+NAP+NADP<br /> | **[[6dfr]] - EcDHFR+NAP+NADP<br /> | ||
**[[1dg8]], [[4kl9]] - MtDHFR +NADPH<BR /> | **[[1dg8]], [[4kl9]] - MtDHFR +NADPH<BR /> | ||
| - | **[[8dfr]] - cDHFR +NADPH<BR /> | ||
**[[3tqa]] – CbDHFR + NADPH<br /> | **[[3tqa]] – CbDHFR + NADPH<br /> | ||
| - | **[[4m6j]] - hDHFR +NADPH<br /> | ||
**[[2xw7]] - DHFR +NADPH – ''Mycobacterium smegmatis''<br /> | **[[2xw7]] - DHFR +NADPH – ''Mycobacterium smegmatis''<br /> | ||
**[[4m7u]] - EfDHFR +NADPH <br /> | **[[4m7u]] - EfDHFR +NADPH <br /> | ||
| - | **[[4q67]] - SaDHFR +NADPH <br /> | + | **[[4q67]], [[6pra]] - SaDHFR +NADPH <br /> |
**[[4q6a]] - SaDHFR (mutant) +NADPH <br /> | **[[4q6a]] - SaDHFR (mutant) +NADPH <br /> | ||
| - | + | **[[8a0n]] – CaDHFR + NADPH <br /> | |
**[[3k74]], [[4i13]], [[4i1n]] – EcDHFR+nanobody<br /> | **[[3k74]], [[4i13]], [[4i1n]] – EcDHFR+nanobody<br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
3D Structures of Dihydrofolate reductase
Updated on 03-April-2025
