6in3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of DOT1L in complex with 18-Crown-6== | |
| + | <StructureSection load='6in3' size='340' side='right'caption='[[6in3]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6in3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IN3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6in3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6in3 OCA], [https://pdbe.org/6in3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6in3 RCSB], [https://www.ebi.ac.uk/pdbsum/6in3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6in3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. | ||
| - | + | ==See Also== | |
| - | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kitakami R]] | ||
| + | [[Category: Kosaka Y]] | ||
| + | [[Category: Matsumoto K]] | ||
| + | [[Category: Mizuguchi M]] | ||
| + | [[Category: Nabeshima Y]] | ||
| + | [[Category: Yokoyama T]] | ||
Current revision
Crystal structure of DOT1L in complex with 18-Crown-6
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