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6og1
From Proteopedia
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==Focus classification structure of the hyperactive ClpB mutant K476C, bound to casein, pre-state== | ==Focus classification structure of the hyperactive ClpB mutant K476C, bound to casein, pre-state== | ||
| - | < | + | <SX load='6og1' size='340' side='right' viewer='molstar' caption='[[6og1]], [[Resolution|resolution]] 3.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6og1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OG1 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6og1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OG1 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6og1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6og1 OCA], [https://pdbe.org/6og1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6og1 RCSB], [https://www.ebi.ac.uk/pdbsum/6og1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6og1 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CLPB_ECOLI CLPB_ECOLI] Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.<ref>PMID:10982797</ref> <ref>PMID:12624113</ref> <ref>PMID:14640692</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
| + | *[[3D structures of ClpB|3D structures of ClpB]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
| + | [[Category: Escherichia coli K-12]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bart | + | [[Category: Bart SM]] |
| - | [[Category: Castellano | + | [[Category: Castellano LM]] |
| - | [[Category: Dimaio | + | [[Category: Dimaio F]] |
| - | [[Category: Gates | + | [[Category: Gates SN]] |
| - | [[Category: Lin | + | [[Category: Lin J-B]] |
| - | [[Category: Rizo | + | [[Category: Rizo AR]] |
| - | [[Category: Shorter | + | [[Category: Shorter J]] |
| - | [[Category: Southworth | + | [[Category: Southworth DR]] |
| - | [[Category: Tse | + | [[Category: Tse E]] |
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Current revision
Focus classification structure of the hyperactive ClpB mutant K476C, bound to casein, pre-state
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Categories: Escherichia coli K-12 | Large Structures | Bart SM | Castellano LM | Dimaio F | Gates SN | Lin J-B | Rizo AR | Shorter J | Southworth DR | Tse E
