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DNA methyltransferase
From Proteopedia
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of DNA methyltransferase == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Methylguanine DNMT | ||
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| - | **[[1sfe]] – O6-methylguanine DNMT C terminal – ''Escherichia coli'' | ||
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| - | **[[1qnt]], [[1eh6]], [[3llr]] - hO6-methylguanine DNMT – human | ||
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| - | **[[1t38]] - hO6-methylguanine DNMT (mutant) + DNA | ||
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| - | **[[1t39]], [[1yfh]] - hO6-methylguanine DNMT + DNA | ||
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| - | **[[1eh7]] - hO6-methylguanine DNMT methylated | ||
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| - | **[[1eh8]] - hO6-methylguanine DNMT benzylated<br /> | ||
| - | **[[1mgt]] - O6-methylguanine DNMT – ''Thermococcus kodakarensis''<br /> | ||
| - | **[[1wrj]] - O6-methylguanine DNMT - ''Sulfolobus tokodaii'' | ||
| - | |||
| - | **[[2g7h]] - O6-methylguanine DNMT – ''Methanocaldococcus jannaschii'' | ||
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| - | **[[2kif]], [[2kim]] - O6-methylguanine DNMT – ''Vibrio parahaemolyticus'' - NMR<br /> | ||
| - | **[[4bhb]], [[4bhc]], [[4wxd]], [[4wxc]] - MtO6-methylguanine DNMT (mutant) – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[4wx9]] - MtO6-methylguanine DNMT (mutant) + modified DNA<br /> | ||
| - | **[[4zyg]], [[4zye]] - O6-methylguanine DNMT – ''Sulfolobus solfataricus''<br /> | ||
| - | **[[5llq]], [[4zyh]] - O6-methylguanine DNMT (mutant) <br /> | ||
| - | **[[4zyd]] - O6-methylguanine DNMT (mutant) + modified DNA<br /> | ||
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| - | *Methylcytosine DNMT | ||
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| - | **[[3epz]] - h-cytosine DNMT 1 replication foci-targeting sequence | ||
| - | **[[4yoc]] - h-cytosine DNMT 1 residues 600-1600 + ubiquitin carboxyl-terminal hydrolase 7<br /> | ||
| - | **[[4z97]], [[4z96]] - h-cytosine DNMT 1 residues 1097-1129 + ubiquitin carboxyl-terminal hydrolase 7<br /> | ||
| - | **[[5ydr]] - h-cytosine DNMT 1 RFTS domain residues 351-599 + ubiquitin<br /> | ||
| - | **[[5wvo]] - h-cytosine DNMT 1 RFTS domain + ubiquitin + histone H3.1<br /> | ||
| - | **[[4wxx]] - h-cytosine DNMT 1 residues 351-1600 + SAH<br /> | ||
| - | **[[1g55]] - h-cytosine DNMT 2 (mutant)<br /> | ||
| - | **[[2qrv]] - h-cytosine DNMT 3A C-terminal domain<br /> | ||
| - | **[[3a1a]] - h-cytosine DNMT 3A ADD domain<br /> | ||
| - | **[[3a1b]], [[4qbq]] - h-cytosine DNMT 3A ADD domain + histone H3<br /> | ||
| - | **[[4qbr]], [[4qbs]] - h-cytosine DNMT 3A ADD domain (mutant) + histone H3<br /> | ||
| - | **[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + SAH<br /> | ||
| - | **[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + histone 3.3 + SAH<br /> | ||
| - | **[[6f57]], [[5yx2]], [[6brr]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3-like residues 178-379 + DNA + SAH + pyrimidine derivative<br /> | ||
| - | **[[3flg]] - h-cytosine DNMT 3B PWWP domain<br /> | ||
| - | **[[3qkj]] - h-cytosine DNMT 3B residues 293-442<br /> | ||
| - | **[[5nvo]] - h-cytosine DNMT 3B PWWP domain + choline<br /> | ||
| - | **[[5nv7]], [[5nv2]], [[5nv0]], [[5nrv]], [[5nrs]], [[5nrr]], [[5nr3]] - h-cytosine DNMT 3B PWWP domain + inhibitor<br /> | ||
| - | **[[5ciu]] - h-cytosine DNMT 3B residues 206-355 + histone H3.2<br /> | ||
| - | **[[3av4]], [[1khc]] - m-cytosine DNMT – mouse<br /> | ||
| - | **[[5wy1]] - m-cytosine DNMT (mutant) <br /> | ||
| - | **[[5guv]], [[5gut]] - m-cytosine DNMT residues 731-1600 (mutant) <br /> | ||
| - | **[[3pt6]], [[3pt9]], [[4da4]] – m-cytosine DNMT + DNA | ||
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| - | **[[3av5]] - m-cytosine DNMT + SAH | ||
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| - | **[[3av6]] - m-cytosine DNMT + SAM | ||
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| - | **[[3swr]] - h-cytosine DNMT + sinefungin | ||
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| - | **[[1boo]] - cytosine DNMT (mutant) – ''Proteus vulgaris''<br /> | ||
| - | **[[3qv2]] - cytosine DNMT + SAH – ''Entamoeba histolytica''<br /> | ||
| - | **[[2uyc]], [[2uyh]], [[2uz4]], [[1fjx]] – Hh-cytosine DNMT (mutant) + DNA + SAH - ''Haemophilus haemolyticus''<br /> | ||
| - | **[[2c7o]], [[2c7p]], [[2c7q]], [[2c7r]], [[3pta]] – Hh-cytosine DNMT + DNA + S-adenonosyl cysteine<br /> | ||
| - | **[[1hmy]] – Hh-cytosine Haeiii DNMT + SAM | ||
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| - | **[[1m0e]] - Hh-cytosine DNMT (mutant) + DNA + inhibitor | ||
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| - | **[[2i9k]] - Hh-cytosine DNMT (mutant) + DNA | ||
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| - | **[[2hr1]] - Hh-cytosine DNMT + DNA + ADOHCY | ||
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| - | **[[2z6q]], [[2z6u]], [[2zcj]] - Hh-cytosine DNMT (mutant) + DNA + ADOHCY | ||
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| - | **[[1svu]] - Hh-cytosine DNMT (mutant)<br /> | ||
| - | **[[4fsx]] – c-cytosine DNMT + SAH – corn<br /> | ||
| - | **[[4ft2]], [[4ft4]] – c-cytosine DNMT + histone H3 peptide<br /> | ||
| - | **[[4h0n]] - cytosine DNMT (mutant) – ''Spodoptera frugiperda''<br/> | ||
| - | **[[6fdf]] - cytosine DNMT2 + SAH – fission yeast<br/> | ||
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| - | *Methyladenine DNMT | ||
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| - | **[[1nw5]] – RsN6-adenine DNMT + SAM – ''Rhodobacter sphaeroides'' | ||
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| - | **[[1nw6]] - RsN6-adenine DNMT + sinefungin<br /> | ||
| - | **[[1nw7]] - RsN6-adenine DNMT + SAH<br /> | ||
| - | **[[1nw8]] - RsN6-adenine DNMT (mutant)<br /> | ||
| - | **[[5hek]] - HpN6-adenine DNMT – ''Helicobacter pylori''<br /> | ||
| - | **[[5hfj]] - HpN6-adenine DNMT + SAM<br /> | ||
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| - | **[[2ibs]], [[2ibt]], [[2ih2]], [[2ih4]], [[2ih5]], [[2np6]], [[2np7]], [[1g38]] - Ta-adenine DNMT Taqi + DNA + cofactor analog – ''Thermus aquaticus''<br /> | ||
| - | **[[1aqi]] – Ta-adenine DNMT Taqi + SAH<br /> | ||
| - | **[[1aqj]] – Ta-adenine DNMT Taqi + sinefungin<br /> | ||
| - | **[[2adm]] - Ta-adenine DNMT Taqi + SAM<br /> | ||
| - | **[[1g60]] - adenine DNMT + SAM – ''Moraxella bovis''<br /> | ||
| - | **[[4rtj]], [[4rtl]], [[4rto]] - Ec-adenine DNMT + DNA + sinefungin<br /> | ||
| - | **[[4rtk]] - Ec-adenine DNMT + DNA + SAH<br /> | ||
| - | **[[4gbe]] - Ec-adenine DNMT + SAH<br /> | ||
| - | **[[4gol]], [[4gom]], [[4gon]], [[4goo]] - Ec-adenine DNMT + SAM derivative<br /> | ||
| - | **[[4rtm]], [[4rtp]], [[4rtr]], [[4rts]] - Ec-adenine DNMT + DNA + AdoMet<br /> | ||
| - | **[[4rtn]], [[4rtq]] - Ec-adenine DNMT + DNA + AdoHcy<br /> | ||
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| - | *HhaI DNA methyltransferase | ||
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| - | **[[1fjx]], [[2hmy]] – HhHDMT + SAM – ''Haemophilus haemolyticus'' <BR /> | ||
| - | **[[1svu]] – HhHDMT (mutant) + SAH <BR /> | ||
| - | **[[1hmy]], [[1mht]], [[3mht]], [[4mht]], [[5mht]], [[7mht]], [[8mht]], [[2hr1]], [[3eeo]] – HhHDMT + DNA + SAH <BR /> | ||
| - | **[[2i9k]], [[2z6a]], [[2z6u]], [[2zcj]] – HhHDMT (mutant) + DNA + SAH <BR /> | ||
| - | **[[6mht]] – HhHDMT + DNA + SAH + thiodeoxycytidine <BR /> | ||
| - | **[[9mht]] – HhHDMT + DNA + SAH + abasic dideoxyribose <BR /> | ||
| - | **[[1skm]] – HhHDMT + DNA + SAH + bicyclohexane <BR /> | ||
| - | **[[10mh]] – HhHDMT + DNA + SAH + dihydroazacytosine <BR /> | ||
| - | **[[1m0e]] – HhHDMT + DNA + SAH + zebularine <BR /> | ||
| - | **[[2c7o]], [[2c7p]], [[2c7q]] – HhHDMT + DNA + SAH + methyl cytosine + aminopurine <BR /> | ||
| - | **[[2c7r]] – HhHDMT (mutant) + DNA + SAH + methyl cytosine + aminopurine <BR /> | ||
| - | **[[2z6q]] – HhHDMT (mutant) + DNA + SAH + deoxycytidine <BR /> | ||
| - | **[[2uyc]], [[2uyh]], [[2uz4]] – HhHDMT (mutant) + DNA + SAH + methyl cytosine <BR /> | ||
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| - | *DNA methyltransferase | ||
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| - | **[[4onj]] – tHDMT catalytic domain + sinefungin – tobacco <BR /> | ||
| - | **[[4onq]] – tHDMT catalytic domain (mutant) + sinefungin <BR /> | ||
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| - | }} | ||
== References == | == References == | ||
Current revision
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References
- ↑ Kaina B, Christmann M, Naumann S, Roos WP. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst). 2007 Aug 1;6(8):1079-99. Epub 2007 May 7. PMID:17485253 doi:http://dx.doi.org/10.1016/j.dnarep.2007.03.008
- ↑ Kumar S, Cheng X, Klimasauskas S, Mi S, Posfai J, Roberts RJ, Wilson GG. The DNA (cytosine-5) methyltransferases. Nucleic Acids Res. 1994 Jan 11;22(1):1-10. PMID:8127644
- ↑ Thomas CB, Scavetta RD, Gumport RI, Churchill ME. Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding. J Biol Chem. 2003 Jul 11;278(28):26094-101. Epub 2003 May 4. PMID:12732637 doi:http://dx.doi.org/10.1074/jbc.M303751200
- ↑ Sankpal UT, Rao DN. Structure, function, and mechanism of HhaI DNA methyltransferases. Crit Rev Biochem Mol Biol. 2002;37(3):167-97. PMID:12139442 doi:http://dx.doi.org/10.1080/10409230290771492
