DnaJ homolog
From Proteopedia
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'''DnaJ homolog subfamily A member 1''' (DnaJA1) is a co-chaperone for HSPA8/Hsc70. DnaJA1 stimulates ATP synthesis and has a role in protein transport into mitochondria<ref>PMID:10816573</ref>.<br /> | '''DnaJ homolog subfamily A member 1''' (DnaJA1) is a co-chaperone for HSPA8/Hsc70. DnaJA1 stimulates ATP synthesis and has a role in protein transport into mitochondria<ref>PMID:10816573</ref>.<br /> | ||
'''DnaJ homolog subfamily B member 1''' (DnaJB1) interacts with HSP70. DnaJB1 stimulates ATP synthesis and the folding of unfolded proteins mediated by HSPA1A <ref>PMID:24318877</ref>.<br /> | '''DnaJ homolog subfamily B member 1''' (DnaJB1) interacts with HSP70. DnaJB1 stimulates ATP synthesis and the folding of unfolded proteins mediated by HSPA1A <ref>PMID:24318877</ref>.<br /> | ||
| + | '''DnaJ homolog subfamily B member 6''' (DnaJB6) acts as co-chaperone of HSP70. <ref>PMID:10954706</ref>.<br /> | ||
| + | '''DnaJ homolog subfamily C member 2''' (DnaJC2) acts as a chaperone for nascent polypeptide chains exiting the ribosome.<br /> | ||
| + | '''DnaJ homolog subfamily C member 3''' (DnaJC3) acts as an inhibitor of the interferon-induced dsRNA-activated protein kinase.<br /> | ||
| + | '''DnaJ homolog subfamily C member 5''' (DnaJC5) acts in membrane trafficking and protein folding.<br /> | ||
| + | '''DnaJ homolog subfamily C member 9''' (DnaJC9) acts as co-chaperone of HSP70. <ref>PMID:17182002</ref>.<br /> | ||
| + | '''DnaJ homolog subfamily C member 10''' (DnaJC10) reduces incorrect disulfide bonds in misfolded glycoproteins.<br /> | ||
== Disease == | == Disease == | ||
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</StructureSection> | </StructureSection> | ||
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| - | ==3D structures of DnaJ homolog== | ||
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| - | *DnaJ homolog subfamily A member 1 | ||
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| - | **[[2lo1]], [[2m6y]] - hDnaJA1 J domain - human - NMR<br /> | ||
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| - | *DnaJ homolog subfamily A member 3 | ||
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| - | **[[2dn9]] - hDnaJA3 J domain - NMR<br /> | ||
| - | **[[2ctt]] - hDnaJ zinc finger domain - NMR<br /> | ||
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| - | *DnaJ homolog subfamily B member 1 | ||
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| - | **[[3agx]], [[2qld]] - hDnaJB1 peptide-binding domain <br /> | ||
| - | **[[3agy]], [[3agz]] - hDnaJB1 peptide-binding domain + HSP70 peptide<br /> | ||
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| - | *DnaJ homolog subfamily B member 2 | ||
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| - | **[[2lgw]] - hDnaJB2 J domain - NMR<br /> | ||
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| - | *DnaJ homolog subfamily B member 8 | ||
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| - | **[[2dmx]] - hDnaJB8 J domain - NMR<br /> | ||
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| - | *DnaJ homolog subfamily B member 9 | ||
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| - | **[[2ctr]] - hDnaJB9 J domain - NMR<br /> | ||
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| - | *DnaJ homolog subfamily B member 12 | ||
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| - | **[[2ctp]] - hDnaJB12 J domain - NMR<br /> | ||
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| - | *DnaJ homolog subfamily C member 1 | ||
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| - | **[[2cqq]], [[2cqr]] - hDnaJC1 DNA-binding domain - NMR<br /> | ||
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| - | *DnaJ homolog subfamily C member 2 | ||
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| - | **[[2m2e]] - hDnaJC2 SANT 2 domain residues 551-621 - NMR<br /> | ||
| - | **[[6cgh]] - hDnaJC2 residues 346-432- NMR<br /> | ||
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| - | *DnaJ homolog subfamily C member 3 | ||
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| - | **[[2y4t]], [[2y4u]] - hDnaJC3 residues 35-461 <br /> | ||
| - | **[[3ieg]] - mDnaJC3 TPR domain <br /> | ||
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| - | *DnaJ homolog subfamily C member 5 | ||
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| - | **[[2ctw]] - DnaJC5 J domain - mouse - NMR<br /> | ||
| - | **[[2n04]], [[2n05]] - hDnaJC5 N terminal domain - NMR<br /> | ||
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| - | *DnaJ homolog subfamily C member 10 | ||
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| - | **[[3apo]] - mDnaJC10 <br /> | ||
| - | **[[5ayk]], [[5ayl]] - mDnaJC10 (mutant)<br /> | ||
| - | **[[3aps]] - hDnaJC10 TRX4 domain <br /> | ||
| - | **[[3apq]] - mDnaJC10 TRX4 domain <br /> | ||
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| - | *DnaJ homolog subfamily C member 12 see Hsp40 in [[Heat Shock Proteins]] | ||
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| - | *DnaJ homolog subfamily C member 17 | ||
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| - | **[[2d9o]] - hDnaJC17 RNA recognition motif 168-254 - NMR<br /> | ||
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| - | *DnaJ homolog subfamily C member 24 | ||
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| - | **[[2l6l]] - hDnaJC24 - NMR<br /> | ||
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| - | *DnaJ homolog subfamily C member 29 or sacsin. Domains: UBL 2-85; SR1 89-336; HEPN 4440-4579 | ||
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| - | **[[5v44]] - hDnaJC29 Sr1 domain <br /> | ||
| - | **[[5v45]], [[5v46]] - hDnaJC29 Sr1 domain (mutant)<br /> | ||
| - | **[[5vsx]] - hDnaJC29 UBL domain<br /> | ||
| - | **[[5vsz]] - hDnaJC29 UBL domain (mutant)<br /> | ||
| - | **[[3o10]] - hDnaJC29 HEPN domain <br /> | ||
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| - | *DnaJ homolog DnJ-2 | ||
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| - | **[[2qsa]] - DnaJ-2 J domain - ''Caenorhabditis elegans''<br /> | ||
| - | }} | ||
== References == | == References == | ||
Current revision
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References
- ↑ Terada K, Mori M. Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70. J Biol Chem. 2000 Aug 11;275(32):24728-34. PMID:10816573 doi:http://dx.doi.org/10.1074/jbc.M002021200
- ↑ Rauch JN, Gestwicki JE. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem. 2014 Jan 17;289(3):1402-14. doi: 10.1074/jbc.M113.521997. Epub 2013 , Dec 5. PMID:24318877 doi:http://dx.doi.org/10.1074/jbc.M113.521997
- ↑ Izawa I, Nishizawa M, Ohtakara K, Ohtsuka K, Inada H, Inagaki M. Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein. J Biol Chem. 2000 Nov 3;275(44):34521-7. PMID:10954706 doi:http://dx.doi.org/10.1074/jbc.M003492200
- ↑ Han C, Chen T, Li N, Yang M, Wan T, Cao X. HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain. Biochem Biophys Res Commun. 2007 Feb 9;353(2):280-5. PMID:17182002 doi:10.1016/j.bbrc.2006.12.013
- ↑ Stark JL, Mehla K, Chaika N, Acton TB, Xiao R, Singh PK, Montelione GT, Powers R. Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry. 2014 Mar 4;53(8):1360-72. doi: 10.1021/bi401329a. Epub 2014 Feb 19. PMID:24512202 doi:http://dx.doi.org/10.1021/bi401329a
- ↑ Suzuki H, Noguchi S, Arakawa H, Tokida T, Hashimoto M, Satow Y. Peptide-binding sites as revealed by the crystal structures of the human Hsp40 Hdj1 C-terminal domain in complex with the octapeptide from human Hsp70. Biochemistry. 2010 Oct 5;49(39):8577-84. Epub 2010 Sep 9. PMID:20809635 doi:10.1021/bi100876n
