User:Leonardo C. Cardoso/Sandbox 1

Structure

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Function

Parkin is an E3 ubiquitin ligase involved in mitophagy via the Pink1-Parkin pathway. Parkin can also act as a transcription factor, downregulating, for instance, the expression of p53 and PS2, and upregulating the expression of PS1.

Disease

Mutations in the Parkin gene are widely associated with recessive juvenile Parkinson's disease forms. Being involved in autophagy via ubiquitinylation and in transcriptional repression of important cell cycle and amyloidogenic genes, it is also implied in Alzheimer's disease forms.

Relevance

Parkin acts as a repressor for p53, which is an important cell cycle regulator, and as a repressor for PS2 and activator of PS1 expression, which are proteins involved in the γ-secretase complex, which is one of the components in the amyloidogenic pathway.

Structural highlights

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