Dual specificity phosphatase 3D structures

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(New page: ==3D structures of dual specificity phosphatase== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Dual specificity...)
Current revision (09:44, 30 April 2025) (edit) (undo)
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Dual specificity phosphatase
+
* Dual specificity phosphatase
-
**[[4y2e]] – hDUSP 7 catalytic domain (mutant) - human<br />
+
**[[6d66]], [[6d67]] – hDUSP 1 (mutant)/MBP - human<br />
 +
**[[6apx]] – hDUSP 1 (mutant)/MBP + monobody<br />
 +
**[[6d65]] – hDUSP 1 (mutant)/MBP + off7<br />
 +
**[[8tk4]], [[8tk5]], [[8tk6]], [[9dj9]] – hDUSP 3 <br />
 +
**[[3f81]], [[8tk2]], [[8tk3]] – hDUSP 3 + inhibitor <br />
 +
**[[1j4x]] – hDUSP 3 (mutant) + peptide<br />
 +
**[[4y2e]] – hDUSP 7 catalytic domain (mutant) <br />
 +
**[[2hxp]] – hDUSP 9<br />
 +
**[[4jmj]], [[4mbb]], [[4nyh]] – hDUSP 11 (mutant) or RNA/RNP complex-1 interacting phosphatase<br />
 +
**[[4jnb]], [[4ki9]] – hDUSP 12<br />
 +
**[[2gwo]], [[2pq5]] – hDUSP 13<br />
**[[5xjv]] – hDUSP 13A (mutant) <br />
**[[5xjv]] – hDUSP 13A (mutant) <br />
-
**[[4yr8]] – hDUSP 16 residues 156-301 + MAPK 8<br />
+
**[[2wgp]] – hDUSP 14<br />
 +
**[[1yz4]] – hDUSP 15 catalytic domain (mutant) <br />
 +
**[[2vsw]] – hDUSP 16 rhodanese domain<br />
 +
**[[2esb]] – hDUSP 18<br />
 +
**[[3s4e]] – hDUSP 19<br />
 +
**[[4d3p]], [[4d3q]], [[4d3r]] – hDUSP 19 (mutant)<br />
 +
**[[1wrm]], [[6lvq]] – hDUSP 22<br />
 +
**[[6l1s]], [[6lmy]], [[6lot]], [[6lou]], [[7c8s]] – hDUSP 22 (mutant) <br />
**[[4woh]] – hDUSP 22 (mutant) + nitrophenolphosphate<br />
**[[4woh]] – hDUSP 22 (mutant) + nitrophenolphosphate<br />
-
**[[5gtj]] – hDUSP 26 (mutant) <br />
+
**[[4erc]] – hDUSP 23 + metavanadate<br />
 +
**[[2img]] – hDUSP 23 + malate<br />
 +
**[[2e0t]], [[4hrf]] – hDUSP 26<br />
 +
**[[4b04]], [[5gtj]] – hDUSP 26 (mutant) <br />
 +
**[[2y96]] – hDUSP 27<br />
**[[5y15]], [[5y16]] – hDUSP 28 (mutant) <br />
**[[5y15]], [[5y16]] – hDUSP 28 (mutant) <br />
 +
 +
* hDUSP 5 see [[MAP kinase phosphatase]] MKP-3<br />
 +
* hDUSP 10 see [[MAP kinase phosphatase]] MKP-5<br />
 +
* hDUSP 14 see [[MAP kinase phosphatase]] MKP-6<br />
 +
* hDUSP 16 see [[MAP kinase phosphatase]] MKP-7<br />
 +
 +
* Viral dual specificity phosphatase
 +
 +
**[[2q05]], [[2rf6]], [[3cm3]] – DUSP – Vaccinia virus<br />
 +
**[[2p4d]] – DUSP – Variola virus<br />
 +
**[[7ncy]] – DUSP – Sulfolobales beppu filamentous virus<br />
*Slingshot phosphatase (SSH)
*Slingshot phosphatase (SSH)
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**[[2nt2]] – hSSH-2L catalytic domain - human<br />
**[[2nt2]] – hSSH-2L catalytic domain - human<br />
-
*Phosphatase of regenerating liver (PRL)
+
*Phosphatase of regenerating liver (PRL) or protein tyrosine phosphatase type IVA
 +
**[[1rxd]] – hPRL-1 <br />
**[[1xm2]] – hPRL-1 (mutant)<br />
**[[1xm2]] – hPRL-1 (mutant)<br />
-
**[[1zck]], [[1x24]] – rPRL-1 - rat<br />
+
**[[5bx1]] – hPRL-1 + inhibitor<br />
-
**[[1zcl]] – rPRL-1 (mutant)<br />
+
**[[5k25]], [[5k23]] – hPRL-2 + magnesium transporter<br />
 +
**[[5k22]], [[6wur]] – hPRL-2 (mutant) + magnesium transporter<br />
**[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br />
**[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br />
 +
**[[5tsr]] – hPRL-3 + magnesium transporter<br />
 +
**[[1zck]], [[1x24]] – rPRL-1 - rat<br />
 +
**[[1zcl]] – rPRL-1 (mutant)<br />
 +
**[[3rz2]] – rPRL-1 + peptide<br />
 +
**[[5mmz]], [[5lxq]], [[6wus]] – mPRL-1 + magnesium transporter - mouse<br />
 +
**[[5k24]] – mPRL-2 + magnesium transporter<br />
*Cdc14
*Cdc14
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**[[1ohc]], [[1ohd]] – hCdc14B2 core domain <br />
**[[1ohc]], [[1ohd]] – hCdc14B2 core domain <br />
**[[1ohe]] – hCdc14B2 core domain + peptide<br />
**[[1ohe]] – hCdc14B2 core domain + peptide<br />
 +
**[[6g86]] – hCdc14 + SIC1 peptide<br />
 +
**[[6g85]], [[6g84]] – hCdc14 + CBK1 peptide<br />
 +
**[[5xw5]] – hCdc14 + SWI6P peptide<br />
 +
**[[5xw4]] – yCdc14 - yeast<br />
 +
**[[4zj7]] – yCdc14 C-terminal + importin<br />
*Cdc25
*Cdc25
 +
**[[8roz]] – hCdc25A catalytic domain + CDK2 + cyclin A2 – Cryo EM<br />
**[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br />
**[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br />
**[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br />
**[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br />
 +
**[[4wh7]] – hCdc25B catalytic domain (mutant) + ligand<br />
 +
**[[4wh9]] – hCdc25B catalytic domain (mutant) + inhibitor<br />
 +
**[[3op3]] – hCdc25C <br />
 +
**[[1t3k]] – Cdc25 – ''Arabidopsis thaliana'' - NMR<br />
*Phosphoinositide phosphatase PTEN
*Phosphoinositide phosphatase PTEN
**[[1d5r]], [[5bzz]], [[5bzx]], [[5bug]] – hPTEN (mutant)<br />
**[[1d5r]], [[5bzz]], [[5bzx]], [[5bug]] – hPTEN (mutant)<br />
 +
 +
*Phosphoinositide phosphatase Sac1
 +
 +
**[[3lwt]] – ySac1<br />
 +
**[[4tu3]] – ySac1 + VPS74<br />
 +
 +
*Phosphoinositide phosphatase Sac2
 +
 +
**[[4xuu]] – hSac2 residues 169-563<br />
*Myotubularin-related protein (MTMR)
*Myotubularin-related protein (MTMR)
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**[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br />
**[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br />
**[[2yf0]] – hMTMR6<br />
**[[2yf0]] – hMTMR6<br />
 +
 +
*Myotubularin-related protein 15 (MTMR15) or Fanconi-associated nuclease 1
 +
 +
**[[4rid]], [[4ry3]] – hMTMR15 residues 370-1009<br />
 +
**[[4rec]], [[4ri8]], [[4ri9]], [[4ria]], [[4rib]], [[4ric]], [[4reb]], [[4rea]] – hMTMR15 (mutant) + DNA<br />
*MAPK phosphatase see [[MAP kinase phosphatase]]
*MAPK phosphatase see [[MAP kinase phosphatase]]

Current revision

3D structures of dual specificity phosphatase

Updated on 30-April-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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