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3bwp

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(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_3bwp", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
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[[Image:3bwp.jpg|left|200px]]
 
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==Crystal structure of a self-spliced group II intron==
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The line below this paragraph, containing "STRUCTURE_3bwp", creates the "Structure Box" on the page.
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<StructureSection load='3bwp' size='340' side='right'caption='[[3bwp]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bwp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oceanobacillus_iheyensis Oceanobacillus iheyensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BWP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3bwp| PDB=3bwp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bwp OCA], [https://pdbe.org/3bwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bwp RCSB], [https://www.ebi.ac.uk/pdbsum/3bwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bwp ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of a self-spliced group II intron'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Oceanobacillus iheyensis]]
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Group II introns are self-splicing ribozymes that catalyze their own excision from precursor transcripts and insertion into new genetic locations. Here we report the crystal structure of an intact, self-spliced group II intron from Oceanobacillus iheyensis at 3.1 angstrom resolution. An extensive network of tertiary interactions facilitates the ordered packing of intron subdomains around a ribozyme core that includes catalytic domain V. The bulge of domain V adopts an unusual helical structure that is located adjacent to a major groove triple helix (catalytic triplex). The bulge and catalytic triplex jointly coordinate two divalent metal ions in a configuration that is consistent with a two-metal ion mechanism for catalysis. Structural and functional analogies support the hypothesis that group II introns and the spliceosome share a common ancestor.
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[[Category: Keating KS]]
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[[Category: Pyle AM]]
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==About this Structure==
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[[Category: Taylor SD]]
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3BWP is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BWP OCA].
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[[Category: Toor N]]
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==Reference==
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Crystal structure of a self-spliced group II intron., Toor N, Keating KS, Taylor SD, Pyle AM, Science. 2008 Apr 4;320(5872):77-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18388288 18388288]
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[[Category: Single protein]]
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[[Category: Keating, K S.]]
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[[Category: Pyle, A M.]]
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[[Category: Taylor, S D.]]
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[[Category: Toor, N.]]
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[[Category: Group ii]]
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[[Category: Intron]]
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[[Category: Ribonucleic acid]]
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[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 16 23:13:05 2008''
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Current revision

Crystal structure of a self-spliced group II intron

PDB ID 3bwp

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