6p9g

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(New page: '''Unreleased structure''' The entry 6p9g is ON HOLD Authors: Tempel, W., Mann, M.K., Harding, R.J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Schapira, M., Structural Genomics Cons...)
Current revision (10:19, 23 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6p9g is ON HOLD
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==Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 2-(4-oxoquinazolin-3(4H)-yl)propanoic acid==
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<StructureSection load='6p9g' size='340' side='right'caption='[[6p9g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P9G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O4Y:(2R)-2-(4-oxoquinazolin-3(4H)-yl)propanoic+acid'>O4Y</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p9g OCA], [https://pdbe.org/6p9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p9g RCSB], [https://www.ebi.ac.uk/pdbsum/6p9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p9g ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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USP5 disassembles unanchored polyubiquitin chains to recycle free monoubiquitin, and is one of the 12 ubiquitin specific proteases featuring a zinc finger ubiquitin-binding domain (ZnF-UBD). This distinct structural module has been associated with substrate positioning or allosteric modulation of catalytic activity, but its cellular function remains unclear. We screened a chemical library focused on the ZnF-UBD of USP5, crystallized hits in complex with the protein, and generated a preliminary structure-activity relationship, which enables the development of more potent and selective compounds. This work serves as a framework for the discovery of a chemical probe to delineate the function of USP5 ZnF-UBD in proteasomal degradation and other ubiquitin signaling pathways in health and disease.
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Authors: Tempel, W., Mann, M.K., Harding, R.J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Schapira, M., Structural Genomics Consortium (SGC)
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Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain.,Mann MK, Franzoni I, de Freitas RF, Tempel W, Houliston S, Smith L, Vedadi M, Arrowsmith CH, Harding RJ, Schapira M J Med Chem. 2019 Nov 27;62(22):10144-10155. doi: 10.1021/acs.jmedchem.9b00988., Epub 2019 Nov 12. PMID:31663737<ref>PMID:31663737</ref>
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Description: Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 2-(4-oxoquinazolin-3(4H)-yl)propanoic acid
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Arrowsmith, C.H]]
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<div class="pdbe-citations 6p9g" style="background-color:#fffaf0;"></div>
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[[Category: Mann, M.K]]
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[[Category: Schapira, M]]
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==See Also==
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[[Category: Edwards, A.M]]
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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== References ==
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[[Category: Harding, R.J]]
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<references/>
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[[Category: Bountra, C]]
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__TOC__
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[[Category: Tempel, W]]
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Edwards AM]]
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[[Category: Harding RJ]]
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[[Category: Mann MK]]
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[[Category: Schapira M]]
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[[Category: Tempel W]]

Current revision

Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 2-(4-oxoquinazolin-3(4H)-yl)propanoic acid

PDB ID 6p9g

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