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6pbc
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6pbc is ON HOLD Authors: Hajicek, N., Sondek, J. Description: Structural basis for the activation of PLC-gamma isozymes by phosphorylation and canc...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations== | |
| + | <StructureSection load='6pbc' size='340' side='right'caption='[[6pbc]], [[Resolution|resolution]] 2.46Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6pbc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PBC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pbc OCA], [https://pdbe.org/6pbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pbc RCSB], [https://www.ebi.ac.uk/pdbsum/6pbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pbc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/G3V845_RAT G3V845_RAT] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.[PIRNR:PIRNR000952] | ||
| - | + | ==See Also== | |
| - | + | *[[Phospholipase C|Phospholipase C]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Hajicek | + | [[Category: Rattus norvegicus]] |
| + | [[Category: Hajicek N]] | ||
| + | [[Category: Sondek J]] | ||
Current revision
Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations
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