6rxb

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m (Protected "6rxb" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6rxb is ON HOLD until Paper Publication
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==Crystal structure of TetR-Q116A from Acinetobacter baumannii AYE in complex with minocycline==
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<StructureSection load='6rxb' size='340' side='right'caption='[[6rxb]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6rxb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_AYE Acinetobacter baumannii AYE]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RXB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSU:CYSTEINE-S-SULFONIC+ACID'>CSU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MIY:(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE'>MIY</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rxb OCA], [https://pdbe.org/6rxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rxb RCSB], [https://www.ebi.ac.uk/pdbsum/6rxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rxb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B0VCI2_ACIBY B0VCI2_ACIBY] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.[ARBA:ARBA00002856]
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Authors: Tam, H.K., Himpich, S., Pos, K.M.
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==See Also==
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
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Description: Crystal structure of TetR-Q116A from Acinetobacter baumannii AYE in complex with minocycline
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Tam, H.K]]
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[[Category: Acinetobacter baumannii AYE]]
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[[Category: Pos, K.M]]
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[[Category: Large Structures]]
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[[Category: Himpich, S]]
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[[Category: Himpich S]]
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[[Category: Pos KM]]
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[[Category: Tam HK]]

Current revision

Crystal structure of TetR-Q116A from Acinetobacter baumannii AYE in complex with minocycline

PDB ID 6rxb

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