4zeg

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<StructureSection load='4zeg' size='340' side='right'caption='[[4zeg]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
<StructureSection load='4zeg' size='340' side='right'caption='[[4zeg]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zeg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZEG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zeg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZEG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=052:N-CYCLOPROPYL-2-METHYL-4-(7-{[2-(MORPHOLIN-4-YL)ETHYL]AMINO}-5-PHENOXYPYRAZOLO[1,5-A]PYRIMIDIN-3-YL)BENZAMIDE'>052</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTK, MPS1, MPS1L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=052:N-CYCLOPROPYL-2-METHYL-4-(7-{[2-(MORPHOLIN-4-YL)ETHYL]AMINO}-5-PHENOXYPYRAZOLO[1,5-A]PYRIMIDIN-3-YL)BENZAMIDE'>052</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zeg OCA], [https://pdbe.org/4zeg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zeg RCSB], [https://www.ebi.ac.uk/pdbsum/4zeg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zeg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zeg OCA], [http://pdbe.org/4zeg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zeg RCSB], [http://www.ebi.ac.uk/pdbsum/4zeg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zeg ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
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[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dual-specificity kinase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Awrey, D E]]
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[[Category: Awrey DE]]
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[[Category: Battaile, K]]
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[[Category: Battaile K]]
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[[Category: Chirgadze, N Y]]
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[[Category: Chirgadze NY]]
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[[Category: Feher, M]]
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[[Category: Feher M]]
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[[Category: Plotnikova, O]]
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[[Category: Plotnikova O]]
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[[Category: Qiu, W]]
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[[Category: Qiu W]]
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[[Category: Inhibitor]]
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[[Category: Kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Ttk]]
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Current revision

Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor

PDB ID 4zeg

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OCA

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