Enoyl-Acyl-Carrier Protein Reductase
From Proteopedia
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<StructureSection load='3fne' size='350' side='right' scene='43/434541/Cv/3' caption='Enoyl-Acyl-Carrier Protein Reductase tetramer complex with NAD and triclosan derivative (PDB code [[3fne]]) '> | <StructureSection load='3fne' size='350' side='right' scene='43/434541/Cv/3' caption='Enoyl-Acyl-Carrier Protein Reductase tetramer complex with NAD and triclosan derivative (PDB code [[3fne]]) '> | ||
| + | __TOC__ | ||
| + | ==Function== | ||
[[Enoyl-Acyl-Carrier Protein Reductase]] (ENR) is an enzyme in the fatty acid synthesis. For additional details see<br /> | [[Enoyl-Acyl-Carrier Protein Reductase]] (ENR) is an enzyme in the fatty acid synthesis. For additional details see<br /> | ||
*[[InhA]] - NADH-dependent trans ENR<br /> | *[[InhA]] - NADH-dependent trans ENR<br /> | ||
| + | *[[Fatty acid synthesis]] | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | <scene name='43/434541/Cv/10'>Enoyl-Acyl-Carrier Protein Reductase is a tetramer</scene>. InhA ENR <scene name='43/434541/Cv/11'>active site contains NAD and | + | <scene name='43/434541/Cv/10'>Enoyl-Acyl-Carrier Protein Reductase is a tetramer</scene>. InhA ENR <scene name='43/434541/Cv/11'>active site contains NAD and triclosan derivative</scene>.<ref>PMID:19130456</ref> |
== 3D Structures of Enoyl-Acyl-Carrier Protein Reductase == | == 3D Structures of Enoyl-Acyl-Carrier Protein Reductase == | ||
Current revision
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References
- ↑ Freundlich JS, Wang F, Vilcheze C, Gulten G, Langley R, Schiehser GA, Jacobus DP, Jacobs WR Jr, Sacchettini JC. Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis. ChemMedChem. 2009 Jan 7. PMID:19130456 doi:10.1002/cmdc.200800261
