Enoyl-CoA hydratase
From Proteopedia
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== Function == | == Function == | ||
| - | '''Enoyl-CoA hydratase''' (ECH) is part of the fatty acid metabolism. | + | '''Enoyl-CoA hydratase''' (ECH) (gene '''rpfF''') is part of the fatty acid metabolism ([[Beta oxidation]]). ECH hydrates the double bond between the second and third carbons in acyl-CoA. |
| + | *'''ECH1''' or '''short-chain ECH''' is mitochondrial. It processes enoyl-CoA thioesters from C4 to C16<ref>PMID:12467702</ref>. | ||
| + | *'''ECH2''' hydrates enoyl-CoA to 3-hydroxyacyl-CoA in the oxidation of fatty acids pathway<ref>PMID:15051722</ref>. | ||
| + | *'''Enoyl-CoA hydratase/isomerase''' catalyzes the hydration and hydrolysis of methylthioacryloyl-CoA in the last step of the methanethiol pathway of dimethyl-sulphoniopropionate catabolism<ref>PMID:23704947</ref>. | ||
== Disease == | == Disease == | ||
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</StructureSection> | </StructureSection> | ||
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| - | ==3D structures of enoyl-CoA hydratase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Enoyl-CoA hydratase | ||
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| - | **[[1uiy]], [[1wz8]] – ECH – ''Thermus thermophilus''<br /> | ||
| - | **[[2ppy]], [[2ej5]], [[2pbp]], [[2qq3]] – ECH – ''Geobacillus kaustophilus''<br /> | ||
| - | **[[3lke]] – ECH – ''Bacillus halodurans''<br /> | ||
| - | **[[3myb]], [[3njb]], [[3njd]], [[3pe8]], [[4qfe]], [[5e0n]], [[3ome]] – ECH – ''Mycobacterium smegmatis''<br /> | ||
| - | **[[3oc7]], [[3p85]], [[3q1t]], [[3qyr]], [[4lk5]], [[4knp]] – MaECH – ''Mycobacterium avium''<br /> | ||
| - | **[[3h81]], [[3he2]], [[3pzk]], [[4jjt]], [[4z0m]], [[5kjp]] – MtECH – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[3t3w]] – ECH – ''Mycobacterium thermoresistibile''<br /> | ||
| - | **[[3r6h]], [[3qmj]], [[3qka]] , [[3qre]], [[3qxi]], [[4di1]], [[4f47]] – MmECH – ''Mycobacterium marinum''<br /> | ||
| - | **[[6c7c]] – ECH – ''Mycobacterium ulcerans''<br /> | ||
| - | **[[5z7r]] – ECH – ''Clostridium acetobutylicum''<br /> | ||
| - | **[[4j2u]] – ECH – ''Rhodobacter sphaeroides''<br /> | ||
| - | **[[4jyl]] – ECH – ''Thermoplasma volcanium''<br /> | ||
| - | **[[4jfc]] – ECH – ''Polaromonas''<br /> | ||
| - | **[[4jsb]] – TfECH – ''Thermobifida fusca''<br /> | ||
| - | **[[1iq6]] – ECH – ''Aeromonas punctata''<br /> | ||
| - | **[[5ve2]] – ECH – ''Pseudoalteromonas atlantica''<br /> | ||
| - | **[[5xzd]] – ECH – ''Roseovarius nubinhibens''<br /> | ||
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| - | *''Enoyl-CoA hydratase complexes'' | ||
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| - | **[[4fzw]] – ECH + epoxyphenylacetyl-CoA isomerase – ''Escherichia coli''<br /> | ||
| - | **[[4jvt]] – TfECH + acetyl-CoA<br /> | ||
| - | **[[4omr]] – TfECH + acetoacetyl-CoA<br /> | ||
| - | **[[3qk8]] – MmECH + ligand<br /> | ||
| - | **[[5dtw]] – MtECH + arachinoyl-CoA<br /> | ||
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| - | *Enoyl-CoA hydratase/isomerase | ||
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| - | **[[3p5m]] – MaECH <br /> | ||
| - | **[[4jcs]] – ECH – ''Cupriavidus metallidurans''<br /> | ||
| - | **[[4k29]] – ECH – ''Xanthobacter autotrophicus''<br /> | ||
| - | **[[4k3w]] – ECH – ''Marinobacter aquaeolei''<br /> | ||
| - | **[[4kpk]] – ECH – ''Shewanella pealeana''<br /> | ||
| - | **[[3ju1]] – ECH – ''Shewanella oneidensis''<br /> | ||
| - | **[[4jyj]], [[4og1]], [[4wcz]]– NaECH – ''Novosphingobium aromaticivorans''<br /> | ||
| - | **[[4kd6]] – ECH – ''Burkholderia graminis''<br /> | ||
| - | **[[3kqf]], [[3pea]] – ECH – ''Bacillus anthracis''<br /> | ||
| - | **[[3l3s]], [[4izb]] – RpECH – ''Ruegeria pomeroyi''<br /> | ||
| - | **[[3ot6]] – ECH – ''Pseudomonas syringae''<br /> | ||
| - | **[[3lao]], [[5cpg]] – ECH – ''Pseudomonas aeruginosa''<br /> | ||
| - | **[[4hc8]], [[4fn7]] – MtECH <br /> | ||
| - | **[[3rrv]], [[3tlf]] – MaECH <br /> | ||
| - | **[[3qxz]], [[3r9q]] – ECH – ''Mycobacterium abscessus''<br /> | ||
| - | **[[4mou]] – ECH – ''Anthrobacter aurescens''<br /> | ||
| - | **[[4olq]], [[5c9g]] – ECH – ''Hyphomonas neptunium''<br /> | ||
| - | **[[3i47]] – ECH – ''Legionella pneumophila''<br /> | ||
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| - | *''Enoyl-CoA hydratase/isomerase complexes'' | ||
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| - | **[[4fn8]], [[3q0j]] – MtECH + acetoacetyl-CoA<br /> | ||
| - | **[[4fnb]] – MtECH + hydroxybutyryl-CoA<br /> | ||
| - | **[[4fnd]] – MtECH + hydroxyhexanoyl-CoA<br /> | ||
| - | **[[3q0g]] – MtECH + butyryl-CoA + CoA<br /> | ||
| - | **[[4izd]], [[4izc]] – RpECH (mutant) + CoA derivative<br /> | ||
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| - | *Enoyl-CoA hydratase 1 | ||
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| - | **[[2hw5]] – ECH1 - human <br /> | ||
| - | **[[4jwv]] – NaECH1 <br /> | ||
| - | **[[1dub]] – rECH1 - rat <br /> | ||
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| - | *''Enoyl-CoA hydratase 1 complexes'' | ||
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| - | **[[2dub]] – rECH1 + octanoyl-CoA<br /> | ||
| - | **[[1ey3]] – rECH1 + cinnamoyl-CoA<br /> | ||
| - | **[[1mj3]] – rECH + hexadienoyl-CoA<br /> | ||
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| - | *Enoyl-CoA hydratase/carnithine racemase | ||
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| - | **[[4k2n]], [[4nek]] – ECH – ''Magnetospirillum magneticum''<br /> | ||
| - | }} | ||
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== References == | == References == | ||
Current revision
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References
- ↑ Agnihotri G, Liu HW. Enoyl-CoA hydratase. reaction, mechanism, and inhibition. Bioorg Med Chem. 2003 Jan 2;11(1):9-20. PMID:12467702
- ↑ Koski MK, Haapalainen AM, Hiltunen JK, Glumoff T. A two-domain structure of one subunit explains unique features of eukaryotic hydratase 2. J Biol Chem. 2004 Jun 4;279(23):24666-72. Epub 2004 Mar 29. PMID:15051722 doi:10.1074/jbc.M400293200
- ↑ Tan D, Crabb WM, Whitman WB, Tong L. Crystal Structure of DmdD, a Crotonase Superfamily Enzyme That Catalyzes the Hydration and Hydrolysis of Methylthioacryloyl-CoA. PLoS One. 2013 May 21;8(5):e63870. doi: 10.1371/journal.pone.0063870. Print 2013. PMID:23704947 doi:10.1371/journal.pone.0063870
- ↑ Sakai C, Yamaguchi S, Sasaki M, Miyamoto Y, Matsushima Y, Goto Y. ECHS1 mutations cause combined respiratory chain deficiency resulting in Leigh syndrome. Hum Mutat. 2015 Feb;36(2):232-9. doi: 10.1002/humu.22730. PMID:25393721 doi:http://dx.doi.org/10.1002/humu.22730
- ↑ Bell AF, Feng Y, Hofstein HA, Parikh S, Wu J, Rudolph MJ, Kisker C, Whitty A, Tonge PJ. Stereoselectivity of enoyl-CoA hydratase results from preferential activation of one of two bound substrate conformers. Chem Biol. 2002 Nov;9(11):1247-55. PMID:12445775
