6s06

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:32, 24 January 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6s06 is ON HOLD until Paper Publication
+
==Crystal structure of haloalkane dehalogenase LinB D147C+L177C mutant (LinB73) from Sphingobium japonicum UT26==
 +
<StructureSection load='6s06' size='340' side='right'caption='[[6s06]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[6s06]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingobium_japonicum_UT26S Sphingobium japonicum UT26S]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S06 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s06 OCA], [https://pdbe.org/6s06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s06 RCSB], [https://www.ebi.ac.uk/pdbsum/6s06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s06 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/LINB_SPHJU LINB_SPHJU] Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Has a broad substrate specificity since not only monochloroalkanes (C3 to C10) but also dichloroalkanes (> C3), bromoalkanes, and chlorinated aliphatic alcohols are good substrates (PubMed:9293022, PubMed:10100638). Shows almost no activity with 1,2-dichloroethane, but very high activity with the brominated analog (PubMed:9293022). Is involved in the degradation of the important environmental pollutant gamma-hexachlorocyclohexane (gamma-HCH or lindane) as it also catalyzes conversion of 1,3,4,6-tetrachloro-1,4-cyclohexadiene (1,4-TCDN) to 2,5-dichloro-2,5-cyclohexadiene-1,4-diol (2,5-DDOL) via the intermediate 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (2,4,5-DNOL) (PubMed:7691794). This degradation pathway allows S.japonicum UT26 to grow on gamma-HCH as the sole source of carbon and energy.<ref>PMID:10100638</ref> <ref>PMID:7691794</ref> <ref>PMID:9293022</ref>
-
Authors: Iermak, I., Mesters, J.R., Degtjarik, O., Chaloupkova, R., Kuta Smatanova, I.
+
==See Also==
-
 
+
*[[Dehalogenase 3D structures|Dehalogenase 3D structures]]
-
Description: Crystal structure of haloalkane dehalogenase LinB D147C+L177C mutant (LinB73) from Sphingobium japonicum UT26
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Mesters, J.R]]
+
__TOC__
-
[[Category: Iermak, I]]
+
</StructureSection>
-
[[Category: Degtjarik, O]]
+
[[Category: Large Structures]]
-
[[Category: Kuta Smatanova, I]]
+
[[Category: Sphingobium japonicum UT26S]]
-
[[Category: Chaloupkova, R]]
+
[[Category: Chaloupkova R]]
 +
[[Category: Degtjarik O]]
 +
[[Category: Iermak I]]
 +
[[Category: Kuta Smatanova I]]
 +
[[Category: Mesters JR]]

Current revision

Crystal structure of haloalkane dehalogenase LinB D147C+L177C mutant (LinB73) from Sphingobium japonicum UT26

PDB ID 6s06

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6s06"
Personal tools