6j61

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Current revision (10:01, 22 November 2023) (edit) (undo)
 
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<StructureSection load='6j61' size='340' side='right'caption='[[6j61]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='6j61' size='340' side='right'caption='[[6j61]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6j61]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J61 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6j61]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J61 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase_(FAD) Thymidylate synthase (FAD)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.148 2.1.1.148] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j61 OCA], [http://pdbe.org/6j61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j61 RCSB], [http://www.ebi.ac.uk/pdbsum/6j61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j61 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j61 OCA], [https://pdbe.org/6j61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j61 RCSB], [https://www.ebi.ac.uk/pdbsum/6j61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j61 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/THYX_THET8 THYX_THET8]] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.[HAMAP-Rule:MF_01408]
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[https://www.uniprot.org/uniprot/THYX_THET8 THYX_THET8] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.[HAMAP-Rule:MF_01408]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6j61" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6j61" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kawai, G]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Ogawa, A]]
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[[Category: Kawai G]]
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[[Category: Sampei, G]]
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[[Category: Ogawa A]]
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[[Category: C-terminal domain]]
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[[Category: Sampei G]]
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[[Category: Pyrimidine nucleotide biosynthetic pathway]]
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[[Category: Structural genomic]]
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[[Category: Thymidylate synthase]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Thymidylate Synthase, Thy1, from Thermus thermophilus having an Extra C Terminal Domain

PDB ID 6j61

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