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5a5s

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<StructureSection load='5a5s' size='340' side='right'caption='[[5a5s]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
<StructureSection load='5a5s' size='340' side='right'caption='[[5a5s]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5a5s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A5S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5a5s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A5S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NP8:5-(5-METHOXYPYRIDIN-3-YL)-3-METHYL-8-[(PIPERIDIN-4-YL)AMINO]-1,2-DIHYDRO-1,7-NAPHTHYRIDIN-2-ONE'>NP8</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a5n|5a5n]], [[5a5o|5a5o]], [[5a5p|5a5p]], [[5a5q|5a5q]], [[5a5r|5a5r]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NP8:5-(5-METHOXYPYRIDIN-3-YL)-3-METHYL-8-[(PIPERIDIN-4-YL)AMINO]-1,2-DIHYDRO-1,7-NAPHTHYRIDIN-2-ONE'>NP8</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a5s OCA], [http://pdbe.org/5a5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a5s RCSB], [http://www.ebi.ac.uk/pdbsum/5a5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a5s ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a5s OCA], [https://pdbe.org/5a5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a5s RCSB], [https://www.ebi.ac.uk/pdbsum/5a5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a5s ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bamborough, P]]
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[[Category: Bamborough P]]
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[[Category: Chung, C]]
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[[Category: Chung C]]
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[[Category: Demont, E]]
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[[Category: Demont E]]
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[[Category: Antagonist]]
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[[Category: Brd4]]
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[[Category: Bromodomain]]
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[[Category: Bromodomain containing protein 4]]
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[[Category: Epigenetic reader]]
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[[Category: Histone]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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Current revision

NN-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 5-5-methoxypyridin-3-yl-3- methyl-8-piperidin-4-ylamino-1,2-dihydro-1,7-naphthyridin-2-one

PDB ID 5a5s

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