This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5a5j
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 3: | Line 3: | ||
<StructureSection load='5a5j' size='340' side='right'caption='[[5a5j]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='5a5j' size='340' side='right'caption='[[5a5j]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5a5j]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5a5j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A5J FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6YF:N-[4-(3-CHLORANYL-4-CYANO-PHENOXY)-3,5-DIMETHOXY-PHENYL]-1,1,1-TRIS(FLUORANYL)METHANESULFONAMIDE'>6YF</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6YF:N-[4-(3-CHLORANYL-4-CYANO-PHENOXY)-3,5-DIMETHOXY-PHENYL]-1,1,1-TRIS(FLUORANYL)METHANESULFONAMIDE'>6YF</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a5j OCA], [https://pdbe.org/5a5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a5j RCSB], [https://www.ebi.ac.uk/pdbsum/5a5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a5j ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CP2C9_HUMAN CP2C9_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan. |
==See Also== | ==See Also== | ||
| Line 16: | Line 15: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | + | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Phillips C]] | |
| - | [[Category: Phillips | + | [[Category: Skerratt SE]] |
| - | [[Category: Skerratt | + | [[Category: De Groot MJ]] |
| - | [[Category: | + | |
Current revision
Cytochrome 2C9 P450 inhibitor complex
| |||||||||||
