Farnesyltransferase
From Proteopedia
(Difference between revisions)
| Line 16: | Line 16: | ||
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of farnesyltransferase== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *FTase | ||
| - | |||
| - | **[[1ft1]] – rFTase – rat<br /> | ||
| - | **[[3q73]] – CnFTase – ''Cryptococcus neoformans'' | ||
| - | |||
| - | *FTase binary complex with FPP | ||
| - | |||
| - | **[[1ft2]], [[1fpp]] – rFTase + FPP<BR /> | ||
| - | **[[1o1r]], [[1o1s]], [[3ksl]], [[3ksq]] - rFTase + FPP-analog<br /> | ||
| - | |||
| - | *FTase binary complex with peptide | ||
| - | |||
| - | **[[1kzp]], [[1o1t]] - rFTase + farnesylated peptide<br /> | ||
| - | **[[2h6f]] - hFTase + farnesylated peptide<br /> | ||
| - | **[[2h6g]], [[2h6h]], [[2h6i]] - hFTase α subunit + β subunit (mutant) + farnesylated peptide<br /> | ||
| - | **[[3q79]] - CnFTase + farnesylated peptide | ||
| - | |||
| - | *FTase binary complex with inhibitor | ||
| - | |||
| - | **[[3eu5]] – rFTase + biotin-GPP<br /> | ||
| - | **[[3euv]] - rFTase α subunit + β subunit (mutant)+ biotin-GPP<br /> | ||
| - | **[[1n94]], [[1n95]], [[1n9a]], [[1o5m]], [[1ni1]], [[1x81]], [[2bed]], [[2r2l]] - rFTase + inhibitor<br /> | ||
| - | **[[1nl4]] - rFTase α subunit (mutant) + β subunit + inhibitor | ||
| - | |||
| - | *FTase ternary complex with FPP and peptide | ||
| - | |||
| - | **[[1d8d]], [[1tn8]] - rFTase + Ras peptide + FPP-analog<br /> | ||
| - | **[[1kzo]] - rFTase + farnesylated Ras peptide + FPP<BR /> | ||
| - | **[[1tn7]], [[3dpy]] - rFTase + peptide + FPP-analog<BR /> | ||
| - | **[[1jcr]], [[1jcs]] - rFTase + tetrapeptide inhibitor + FPP<BR /> | ||
| - | **[[1d8e]] - rFTase no Zn + Ras peptide + FPP-analog<br /> | ||
| - | **[[1tn6]] - hFTase + Rap2a peptide + FPP-analog<br /> | ||
| - | **[[3q75]], [[3q78]] - CnFTase + peptide + FPP-analog<br /> | ||
| - | **[[4l9p]] - AfFTase + peptide + FPP-analog – ''Apergillus fumigatus''<br /> | ||
| - | |||
| - | *FTase ternary complex with FPP and inhibitor | ||
| - | |||
| - | **[[1sa5]], [[3e30]], [[3e32]], [[3e33]], [[3e34]], [[3e37]] - rFTase + inhibitor + FPP<BR /> | ||
| - | **[[4gtm]], [[4gto]], [[4gtp]], [[4gtq]], [[4gtr]] - rFTase α subunit + β subunit + inhibitor + FPP<br /> | ||
| - | **[[2zir]], [[2zis]] - rFTase α subunit (mutant) + β subunit + inhibitor + FPP<BR /> | ||
| - | **[[1jcq]] – hFTase α subunit (mutant) + β subunit + inhibitor + FPP– human<br /> | ||
| - | **[[1ld7]], [[1ld8]], [[1mzc]], [[1sa4]], [[1s63]], [[2f0y]] - hFTase + inhibitor + FPP<BR /> | ||
| - | **[[2iej]] - hFTase + inhibitor + FPP-analog<br /> | ||
| - | **[[3pz4]] - FTase + inhibitor + FPP – mouse<br /> | ||
| - | **[[3q7a]], [[3q7f]] - CnFTase + inhibitor + FPP<BR /> | ||
| - | **[[3fsx]], [[3sfy]] - CnFTase + inhibitor + FPP-analog<br /> | ||
| - | **[[3sfx]] - CnFTase α subunit + β subunit + inhibitor + FPP<br /> | ||
| - | **[[4lnb]], [[4lng]], [[4mbg]] - AfFTase (mutant) + inhibitor + FPP<br /> | ||
| - | |||
| - | *FTase ternary complex with GPP and protein | ||
| - | |||
| - | **[[1n4p]], [[1n4r]], [[1n4s]] - rFTase α subunit + GTase β subunit + transforming protein + GPP<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
References
- ↑ Reid TS, Terry KL, Casey PJ, Beese LS. Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J Mol Biol. 2004 Oct 15;343(2):417-33. PMID:15451670 doi:10.1016/j.jmb.2004.08.056
- ↑ Hast MA, Nichols CB, Armstrong SM, Kelly SM, Hellinga HW, Alspaugh JA, Beese LS. Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens. J Biol Chem. 2011 Oct 7;286(40):35149-62. Epub 2011 Aug 4. PMID:21816822 doi:10.1074/jbc.M111.250506
