Ferritin

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[[Ferritin]] (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).<ref>PMID:20304033</ref> Amphibians have an additional middle subunit FR (FTM).<br />
[[Ferritin]] (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).<ref>PMID:20304033</ref> Amphibians have an additional middle subunit FR (FTM).<br />
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* '''Bacterioferritin''' (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity.<br />
+
* '''apo-ferritin''' (apo-FR) is a non-Fe-containing ferritin.<br />
 +
* '''Bacterioferritin''' (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity<ref>PMID:37375226</ref>.<br />
* '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br />
* '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br />
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* Another iron storing protein is the '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate.<br />
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* '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate which acts as a molecular chaperone and may confer thermotolerance in ''E. coli''<ref>PMID:37229826</ref>.<br />
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* '''MrgA''' – another iron storage protein - belongs to the Dps family.
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== Relevance ==
== Relevance ==
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</StructureSection>
</StructureSection>
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==3D Structures of Ferritin==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Ferritin
 
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**[[2jd6]], [[2jd7]] – PfFR - ''Pyrococcus furiosus'' <br />
 
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**[[3a68]] – soFR from gene SferH4 – soybean<br />
 
-
**[[3a9q]] - soFR from gene SferH4 (mutant) <br />
 
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**[[3egm]], [[3bve]], [[3bvf]], [[3bvi]], [[3bvk]], [[3bvl]] – HpFR – ''Heliobacter pylori''<br />
 
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**[[5c6f]] – HpFR (mutant) + Fe <br />
 
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**[[1z4a]], [[1vlg]] – FR – ''Thermotoga maritime''<br />
 
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**[[1s3q]], [[1sq3]], [[3kx9]], [[5v5k]] – FR – ''Archaeoglubus fulgidus''<br />
 
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**[[1krq]] – FR – ''Campylobacter jejuni''<br />
 
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**[[1eum]] - EcFR – ''Escherichia coli''<br />
 
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**[[1qgh]] – LiFR - ''Listeria innocua''<br />
 
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**[[3qz3]] - VcFR – ''Vibrio cholerae''<br / >
 
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**[[3vnx]] – FR – ''Ulva pertusa''<br />
 
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**[[4ism]], [[4isp]], [[4itt]], [[4itw]], [[4iwj]], [[4iwk]], [[4ixk]], [[3e6r]], [[3e6s]] – PnmFR – ''Pseudo-nitschia multiseries''<br />
 
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**[[4zkh]], [[4zkw]], [[4zkx]], [[4zl5]], [[4zl6]], [[4zlw]], [[4zmc]] – PnmFR (mutant) + Fe<br />
 
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**[[1z6o]] – FR – ''Trichoplusia ni''<br />
 
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**[[5n5f]] – FR – ''Haliangium ochraceum''<br />
 
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**[[5ouz]], [[5ouw]] – SyFR – ''Synechococcus''<br />
 
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**[[6gkc]], [[6gka]] – SyFR + Fe <br />
 
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**[[6gkb]] – SyFR (mutant) + Fe <br />
 
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**[[6a4u]] – FR (mutant) – ''Marsupenaeus japonicus'' <br />
 
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**[[4reu]] – EcFR + Fe<br />
 
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**[[4xgs]] – EcFR (mutant) + Fe2O2<br />
 
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**[[4ztt]] – EcFR (mutant) + Fe2O + Fe2 + Fe + O2<br />
 
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**[[4cmy]] – FR + Fe – ''Chlorobaculum tepidum''<br />
 
- 
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*Ferritin light chain (FTL)
 
- 
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**[[1fha]], [[5lg8]] - hFTL+ Fe - human<br />
 
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**[[3o7s]], [[3u90]], [[6msx]], [[6gxj]] – hoFTL - horse<br />
 
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**[[4v1w]], [[6rjh]] – hoFTL – cryo EM<br />
 
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**[[3noz]], [[3np0]], [[3np2]], [[3o7r]] – hoFTL (mutant) <br />
 
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**[[5lg2]] - hoFTL + Fe<br />
 
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**[[5czu]] - hoFTL (mutant) + Fe<br />
 
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**[[3rav]], [[3rd0]] – hoFTL + barbiturate
 
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**[[1lb3]], [[1h96]] – mFTL – mouse<br />
 
- 
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*Ferritin middle subunit (FTM)
 
- 
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**[[4das]], [[1mfr]], [[1bg7]] – bFTM - bullfrog<br />
 
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**[[4p18]], [[5xhi]], [[5xhm]], [[5xhn]], [[5xho]] – bFTM (mutant) <br />
 
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**[[4lpj]], [[4lqj]], [[6i36]], [[4lqv]], [[4lyu]], [[4lyx]], [[4my7]], [[3rbc]], [[3rgd]] – bFTM + Fe <br />
 
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**[[4mjy]], [[4ml5]], [[4mn9]], [[5j8w]], [[5j93]], [[5j9v]], [[5jac]], [[6iaj]], [[6iaf]], [[6i9t]], [[6i9p]] – bFTM (mutant) + Fe<br />
 
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**[[4lqh]], [[1mfr]], [[3ka3]] – bFTM + Mg<br />
 
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**[[4lpm]], [[4mku]], [[5j8s]], [[3se1]], [[3sh6]], [[3shx]] – bFTM (mutant) + Mg<br />
 
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**[[3ka4]] – bFTM + Co<br />
 
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**[[4lpn]], [[3ka8]], [[3ka6]], [[3ka9]] – bFTM (mutant) + Co<br />
 
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**[[1bg7]] – bFTM + Ca<br />
 
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**[[3re7]] – bFTM + Cu<br />
 
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*Ferritin heavy subunit (FTH)
 
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**[[5gou]], [[5yi5]] – hFTH <br />
 
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**[[5xb1]], [[6ipc]], [[5znd]] – hFTH (mutant)<br />
 
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**[[4oyn]], [[4y08]], [[4zjk]], [[5jkk]], [[5jkl]], [[5jkm]], [[6b8g]], [[6b8f]], [[4ykh]] – hFTH + Fe<br />
 
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**[[6ipp]] – hFTH (mutant) + Fe<br />
 
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**[[3wnw]] – mFTL + Fe<br />
 
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**[[5obA]] – mFTL (mutant) + Fe<br />
 
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**[[2z6o]] – FTH – ''Trichoplusia ni''<br />
 
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*apo-ferritin (apo-FR)
 
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**[[2clu]], [[2cn6]] - apo-hFR (mutant)+Zn <br />
 
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**[[3h7g]] – apo-hoFR+Au <br />
 
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**[[1hrs]] - apo-hoFR+protoporphyrin<br />
 
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**[[5wpn]] - apo-FR (mutant)+Zn – parchment tube worm<br />
 
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**[[2x17]] – apo-PfFR+Ag <br />
 
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**[[2jd8]] – apo-PfFR+Zn<br />
 
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*apo-ferritin light chain (apo-FTL)
 
- 
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**[[2fg8]] – apo-hFTL + Cs<br />
 
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**[[3kxu]], [[2ffx]], [[2fg4]] - apo-hFTL+ Cd<br />
 
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**[[2zg7]], [[2z5p]], [[2z5q]], [[2z5r]], [[3fi6]], [[3af7]], [[5e2d]], [[5hqo]] – apo-hoFTL+Pd<br />
 
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**[[2zg8]], [[2zg9]], [[3af8]], [[3af9]], [[3noz]], [[3np0]], [[3np2]] - apo-hoFTL (mutant)+Pd<br />
 
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**[[6env]] – apo-hoFTL+Au<br />
 
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**[[3o7s]], [[3wvw]] - apo-hoFTL+Ru<br />
 
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**[[2zur]] - apo-hoFTL+Rh<br />
 
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**[[3o7r]], [[3wvu]], [[3wvv]] - apo-hoFTL (mutant) + Ru<br />
 
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**[[4z3b]] - apo-hoFTL + Mn<br />
 
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**[[5axs]], [[5e1u]], [[5erj]], [[5erk]], [[5ix6]], [[5mij]], [[5mik]], [[2w0o]], [[3f32]], [[1ies]], [[1ier]], [[1dat]], [[1aew]], [[2g4h]], [[2za6]] - apo-hoFTL + Cd<br />
 
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**[[6hju]], [[6hjt]] – apo-hoFTL + Pt<br />
 
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**[[6fj9]], [[6fx8]], [[6enw]], [[6env]] – apo-hoFTL + Au<br />
 
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**[[3f33]], [[3f34]], [[3f35]], [[3f36]], [[3f37]], [[3f38]], [[3f39]] - apo-hoFTL+phenols<br />
 
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**[[2v2i]], [[2v2j]] - apo-hoFTL+haemin<br />
 
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**[[2gyd]] - apo-hoFTL+diaziflurane<br />
 
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**[[1xz1]] - apo-hoFTL+halothane<br />
 
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**[[1xz3]] - apo-hoFTL+isoflurane<br />
 
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**[[1gwg]] - apo-hoFTL+I3<br />
 
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**[[2v2l]], [[2v2m]], [[2v2n]], [[2v2o]], [[2v2p]], [[2v2r]], [[2v2s]] - apo-hoFTL (mutant)+haemin<br />
 
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**[[2fg8]] – apo-hFTL + Cs<br />
 
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**[[3kxu]], [[2ffx]], [[2fg4]] - apo-hFTL+ Cd<br />
 
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**[[1fha]], [[5lg8]] - apo-hFTL+ Fe<br />
 
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**[[4de6]] - apo-hoFTL + arachidonic acid<br />
 
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**[[1rcc]], [[1rcd]], [[1rci]] – apo-bFTL+tartrate+Mg<br />
 
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**[[1rce]], [[1rcg]] - apo-bFTL+tartrate+Mn<br />
 
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*apo-ferritin heavy chain (apo-FTH)
 
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**[[3erz]] – apo-hFTH+Hg<br />
 
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**[[3es3]] - apo-hFTH+Au<br />
 
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**[[5z91]], [[5z8s]], [[5z8j]] - apo-hFTH (mutant) +Au<br />
 
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**[[5vtd]] – apo-hFTH+ Co<br />
 
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**[[5up7]] – apo-hFTH+ Ni<br />
 
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**[[5n26]] – apo-hFTH+ Pt<br />
 
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**[[6ftv]] – apo-hFTH + Ru<br />
 
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**[[2fha]] – apo-hFTH + Ca<br />
 
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**[[2cn7]], [[2fha]] – apo-hFTH (mutant) + Ca<br />
 
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**[[2z6m]] – hFTH + Zn<br />
 
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**[[2chi]], [[2clu]], [[2cei]], [[2cih]], [[2cn6]], [[2iu2]], [[5cmq]], [[5cmr]], [[2z6m]] – apo-hFTH (mutant) + Zn<br />
 
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**[[5up8]], [[5up9]] – apo-hFTH+ Zn + oxamate derivative<br />
 
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**[[1r03]], [[3ajo]], [[5n27]] – hFTH + Mg<br />
 
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**[[3ajp]], [[3ajq]], [[6ipq]], [[6ipo]], [[5z8u]] - hFTH (mutant) + Mg<br />
 
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**[[4dyx]], [[4dyy]], [[4dyz]], [[4dz0]] – apo-hFTH (mutant) + Cu<br />
 
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**[[5gu0]], [[5gu1]], [[5gu2]], [[5gu3]], [[2za7]], [[2za8]] - apo-hoFTH (mutant) + Cd<br />
 
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**[[5obb]] – mFTL + Tb<br />
 
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*Ferritin light+heavy chains
 
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**[[5gn8]] – hFTH + Ca<br />
 
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*Bacterioferritin (BFR) 0r ferroxidase
 
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**[[3gvy]] – BFR – ''Rhodobacter sphaeroides''<br />
 
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**[[1jgc]] - BFR – ''Rhodobacter capsulatus''<br />
 
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**[[1ji4]] – BFR – ''Helicobacter pylori''<br />
 
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**[[1nf4]], [[1nf6]], [[1nfv]] – BFR – ''Desulfovibrio desulfuricans''<br />
 
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**[[3fvb]] – BmBFR - ''Brucelia melitensis''<br />
 
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**[[2fkz]], [[2fl0]], [[1sof]] – BFR – ''Azotobacrter vinelandii''<br />
 
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**[[2wtl]], [[3qb9]], [[3uof]], [[3uoi]] – BFR – ''Mycobacterium tuberculosis''<br />
 
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**[[3bkn]] - MsBFR – ''Mycobacterium smegmatis''<br />
 
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**[[3is7]], [[3is8]], [[3ise]], [[3isf]], [[3r2h]], [[3r2k]], [[3r2l]], [[3r2m]], [[3r2o]], [[3r2r]], [[3r2s]], [[6nlf]], [[5d8o]] – PaBFR – ''Pseudomonas aeruginosa''<br />
 
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**[[5d8x]], [[5d8s]], [[5d8r]], [[5d8q]], [[4tog]], [[4tof]], [[4tod]], [[4tob]], [[4to9]] - PaBFR (mutant) <br />
 
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**[[5d8p]] - PaBFR + Fe<br />
 
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**[[5d8y]], [[4toh]], [[4toe]], [[4toc]], [[4toa]] - PaBFR (mutant) + Fe<br />
 
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**[[6nli]], [[6nlk]], [[6nll]], [[6nlm]], [[6nln]] - PaBFR + inhibitor<br />
 
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**[[6nlg]] - PaBFR (mutant) + inhibitor<br />
 
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**[[4E6K]] - PaBFR + BFR-associated protein<br />
 
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**[[1bfr]], [[1bcf]], [[2htn]], [[2vxi]], [[3e1j]], [[3e1l]], [[3e1m]], [[3e1n]], [[3e1p]], [[3e1o]], [[3e1q]], [[2y3q]] – EcBFR <br />
 
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**[[4xku]], [[4xkt]], [[4xks]], [[4u3g]] - EcBFR (mutant) <br />
 
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**[[3e2c]], [[4cvr]], [[4cvt]] – EcBFR (mutant) + Zn<br />
 
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**[[4cvp]], [[3ghq]] - EcBFR (mutant) + Fe<br />
 
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**[[4cvs]] – EcBFR (mutant) + Cd<br />
 
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**[[4am2]], [[4am4]], [[4am5]] – BFR + Fe – ''Blastochloris viridis''<br />
 
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**[[5zur]] - BFR + Fe - ''Achromobacter''<br />
 
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**[[5xx9]] - BFR + Fe – ''Streptomyces coelicolor''<br />
 
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*Thioferritin (TFR)
 
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**[[2vzb]] – TFR – ''Bacterioides fragilis''
 
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*DNA-binding Protein of Starved cells (Dps)
 
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**[[3iq1]] – VcDps <br />
 
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**[[3ge4]] – BmDps <br />
 
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**[[2iy4]] – Dps + Fe – ''Listeria monocytogenes''<br />
 
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**[[2bkc]], [[2bk6]], [[2bjy]] – LiDps (mutant) <br />
 
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**[[6hv1]] – Dps – ''Listeria innocua''<br />
 
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**[[2f7n]] – Dps + Co – ''Deinococcus radiodurans''<br />
 
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**[[4a25]] - Dps + Mn – ''Kinecoccus radiodurans''<br />
 
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**[[1tjo]], [[1tk6]], [[1tkp]], [[1tko]], [[1moj]] – Dps + Fe – ''Halobacterium salinarum''<br />
 
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**[[1o9r]] – Dps + Fe – ''Agrobacterium tumefaciens''<br />
 
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**[[1dps]], [[1f33]], [[5xgo]] – EcDps <br />
 
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**[[1f30]] – EcDps + Zn<br />
 
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**[[1jre]] – EcDps + Cd<br />
 
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**[[1jts]], [[1l8h]], [[1l8i]] – EcDps (mutant)<br />
 
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**[[2ux1]] – SsDps + Zn – ''Streptococcus suis''<br />
 
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**[[2v15]] – SsDps + Te<br />
 
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**[[2xjm]] – SsDps + Co<br />
 
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**[[2xjn]] – SsDps + Cu<br />
 
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**[[2xjo]] – SsDps + Ni<br />
 
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**[[2xkq]] – SsDps + Mn<br />
 
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**[[2yw6]], [[2yw7]] – MsDps<br />
 
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**[[3ak8]], [[3ak9]] – Dps + Mg – ''Salmonella enterica''<br />
 
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**[[1n1q]] – Dps + Fe2O– ''Brevibacillus brevis''<br />
 
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**[[1vei]], [[1vel]], [[1veq]] – MsDps + Fe <br />
 
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**[[4dyu]] – Dps + Zn – ''Yersinia pestis''<br />
 
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**[[5hjf]], [[5hjh]] - NpDps – ''Nostoc punctiforme''<br />
 
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**[[5i4j]] - NpDps + Zn <br />
 
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**[[5h4h]] - NpDps + Fe <br />
 
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*MrgA
 
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**[[2chp]] – MrgA – ''Bacillus subtilis''<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe Pyrococcus furiousus 2jd7

Drag the structure with the mouse to rotate


References

  1. ↑ Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: Past, present and future. Biochim Biophys Acta. 2010 Aug;1800(8):760-9. doi: 10.1016/j.bbagen.2010.03.011. , Epub 2010 Mar 19. PMID:20304033 doi:http://dx.doi.org/10.1016/j.bbagen.2010.03.011
  2. ↑ van der Ven AM, Gyamfi H, Suttisansanee U, Ahmad MS, Su Z, Taylor RM, Poole A, Chiorean S, Daub E, Urquhart T, Honek JF. Molecular Engineering of E. coli Bacterioferritin: A Versatile Nanodimensional Protein Cage. Molecules. 2023 Jun 9;28(12):4663. PMID:37375226 doi:10.3390/molecules28124663
  3. ↑ Park JH, Lee ES, Jung YJ. Functional characterization of the DNA-binding protein from starved cells (DPS) as a molecular chaperone under heat stress. Biochem Biophys Res Commun. 2023 Jul 30;667:180-185. PMID:37229826 doi:10.1016/j.bbrc.2023.05.064

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