Fibroblast growth factor receptor 3D receptor

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(New page: ==3D structures of fibroblast growth factor receptor== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *FGFR1 *''F...)
Current revision (07:06, 3 July 2025) (edit) (undo)
 
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*FGFR1
*FGFR1
-
*''FGFR1 tyrosine kinase domain residues 458-765''
+
**[[8jqi]] – hFGFR1 + PLC gamma – human – Cryo EM<br />
-
**[[4uwy]], [[6mzq]] – hFGFR1 TKD - human<br />
+
*''FGFR1 tyrosine kinase domain (TKD) residues 458-765''
-
**[[1fgk]], [[3kxx]], [[3ky2]], [[4rwi]], [[5flf]] – hFGFR1 TKD (mutant) - human <br />
+
 
-
**[[4wun]], [[5am6]], [[5ew8]], [[5o49]], [[5o4a], [[6mzw]], [[6c1o]] – hFGFR1 TKD + inhibitor <br />
+
**[[4uwy]] – hFGFR1 TKD <br />
-
**[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]], [[5b7v]], [[5am7]], [[4rwj]], [[4rwk]], [[4rwl]], [[4uwb]], [[4uwc]], [[4zsa]], [[5uq0]], [[5vnd]], [[5ur1]], [[6p68]], [[6p69]], [[6c18]], [[6c19]], [[6c1b]], [[6c1c]], [[5z0s]] – hFGFR1 TKD (mutant) + inhibitor <br />
+
**[[1fgk]], [[3kxx]], [[3ky2]], [[4rwi]], [[5flf]] – hFGFR1 TKD (mutant) <br />
-
**[[5zv2]] – hFGFR1 TKD (mutant) + anti-cancer drug<br />
+
**[[4wun]], [[5am6]], [[5ew8]], [[5o49]], [[5o4a]], [[6c1o]], [[6mzq]], [[6mzw]], [[8xlo]], [[8xlq]], [[8xz7]], [[8y22]], [[9cd5]] – hFGFR1 TKD + inhibitor <br />
 +
**[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]], [[5b7v]], [[5am7]], [[4rwj]], [[4rwk]], [[4rwl]], [[4uwb]], [[4uwc]], [[4zsa]], [[5uq0]], [[5vnd]], [[5ur1]], [[6c18]], [[6c19]], [[6c1b]], [[6c1c]], [[5z0s]], [[6agx]], [[6itj]], [[6nvl]], [[6p68]], [[6p69]], [[7ozb]], [[7ozd]], [[7ozf]], [[7ozy]], [[7wct]], [[7wcw]], [[7wcx]] – hFGFR1 TKD (mutant) + inhibitor <br />
 +
**[[8yki]] – hFGFR1 TKD + anti-cancer drug<br />
 +
**[[5zv2]], [[7wcl]], [[8jmz]] – hFGFR1 TKD (mutant) + anti-cancer drug<br />
**[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br />
**[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br />
**[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br />
**[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br />
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**[[3gql]] – hFGFR1 TKD (mutant) + substrate <br />
**[[3gql]] – hFGFR1 TKD (mutant) + substrate <br />
-
*''FGFR1 ligand-binding domain D1 residues 35-208''
+
*''FGFR1 ligand-binding domain (LBD) D1 residues 35-208''
**[[2cr3]] – hFGFR1 LBD D1 - NMR<br />
**[[2cr3]] – hFGFR1 LBD D1 - NMR<br />
**[[2ckn]] – FGFR1 LBD D1 – mouse - NMR<br />
**[[2ckn]] – FGFR1 LBD D1 – mouse - NMR<br />
-
*''FGFR1 D1 complex with FGF''
+
*''FGFR1 LBD D1 complex with FGF''
**[[5w59]] – hFGFR1 LBD D1 + FGF9<br />
**[[5w59]] – hFGFR1 LBD D1 + FGF9<br />
-
*''FGFR1 D2,D3 residues 142-365 complex with FGF''
+
*''FGFR1 LBD D2,D3 residues 142-365 complex with FGF''
**[[3ojv]] – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human <br />
**[[3ojv]] – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human <br />
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**[[1evt]] – hFGFR1 LBD D2,D3 + hFGF1 <br />
**[[1evt]] – hFGFR1 LBD D2,D3 + hFGF1 <br />
**[[1fq9]] – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS<br />
**[[1fq9]] – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS<br />
-
**[[5w21]] – hFGFR1 LBD D2,D3 + hFGF23 + klotho <br />
+
**[[5w21]]. [[7ysh]] – hFGFR1 LBD D2,D3 + hFGF23 + klotho <br />
*FGFR2
*FGFR2
-
*''FGFR2 tyrosine kinase domain''
+
*''FGFR2 tyrosine kinase domain 413-821''
**[[1gjo]], [[1oec]], [[2psq]] – hFGFR2 TKD <br />
**[[1gjo]], [[1oec]], [[2psq]] – hFGFR2 TKD <br />
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**[[3b2t]] – hFGFR2 TKD (mutant) + adenosine derivative<br />
**[[3b2t]] – hFGFR2 TKD (mutant) + adenosine derivative<br />
**[[2pvf]] – hFGFR2 TKD with PTR + ACP + substrate peptide<br />
**[[2pvf]] – hFGFR2 TKD with PTR + ACP + substrate peptide<br />
-
**[[3cly]] – hFGFR2 TKD (mutant) with PTR + ACP <br />
+
**[[3cly]], [[6v6q]] – hFGFR2 TKD (mutant) with PTR + ACP <br />
**[[5eg3]] – hFGFR2 TKD (mutant) with PTR + ACP + phospholipase C γ<br />
**[[5eg3]] – hFGFR2 TKD (mutant) with PTR + ACP + phospholipase C γ<br />
-
**[[3ri1]] – hFGFR2 TKD + inhibitor<br />
+
**[[3ri1]], [[6lvk]], [[6lvl]], [[8e1x]], [[8h75]], [[8stg]], [[8u1f]], [[8w2x]], [[8w38]], [[8w3d]] – hFGFR2 TKD + inhibitor<br />
 +
**[[7kia]], [[7kie]], [[8swe]], [[9u3n]] – hFGFR2 TKD (mutant) + inhibitor<br />
-
*''FGFR2 ligand-binding domain''
+
*FGFR2 ligand-binding domain 134-249
-
**[[3dar]], [[3caf]], [[3euu]] – hFGFR2 LBD D2 <br />
+
**[[3dar]], [[3caf]], [[3euu]] – hFGFR2 LBD D2 150-249<br />
 +
**[[8om6]] – hFGFR2 LBD D2 (mutant) <br />
**[[1wvz]] – hFGFR2 LBD D2 - NMR<br />
**[[1wvz]] – hFGFR2 LBD D2 - NMR<br />
**[[4wv1]] – hFGFR2 LBD D2 + antibody<br />
**[[4wv1]] – hFGFR2 LBD D2 + antibody<br />
-
**[[4hwu]] – hFGFR2 LBD D1 <br />
+
**[[6l4o]] – hFGFR2 LBD D2 (mutant) + API5<br />
 +
**[[4hwu]] – hFGFR2 LBD D1 45-127<br />
*''FGFR2 complex with FGF''
*''FGFR2 complex with FGF''
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**[[3grw]] – hFGFR3 LBD D2,D3 + antibody<br />
**[[3grw]] – hFGFR3 LBD D2,D3 + antibody<br />
**[[2lzl]] – hFGFR3 residues 357-399 – NMR<br />
**[[2lzl]] – hFGFR3 residues 357-399 – NMR<br />
-
**[[4k33]] – hFGFR3 kinase domain (mutant)<br />
+
**[[4k33]] – hFGFR3 TKD (mutant)<br />
 +
**[[6lvm]], [[7dhl]], [[8udt]], [[8udu]], [[8udv]], [[9cd7]], [[9d1x]] – hFGFR3 TKD + inhibitor<br />
 +
**[[6pnx]] – hFGFR3 TKD (mutant) + ACP<br />
*''FGFR3 complex with FGF''
*''FGFR3 complex with FGF''
**[[1ry7]] – hFGFR3 LBD + hFGF1<br />
**[[1ry7]] – hFGFR3 LBD + hFGF1<br />
 +
**[[7ysu]] – hFGFR3 LBD D2,D3 + hFGF23 + klotho – Cryo EM <br />
*FGFR4
*FGFR4
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**[[4tye]], [[4tyg]], [[4tyi]], [[4tyj]] – hFGFR4 TKD <br />
**[[4tye]], [[4tyg]], [[4tyi]], [[4tyj]] – hFGFR4 TKD <br />
**[[4qqj]], [[4qqt]] – hFGFR4 TKD (mutant) <br />
**[[4qqj]], [[4qqt]] – hFGFR4 TKD (mutant) <br />
-
**[[5jkg]], [[5nwz]], [[5nud]] – hFGFR4 TKD + inhibitor<br />
+
**[[5jkg]], [[5nwz]], [[5nud]], [[6nvg]], [[6nvh]], [[6nvi]], [[6nvj]], [[6nvk]], [[6v9c]], [[7dtz]], [[7f3m]], [[7v29]], [[7vjl]], [[7wct]], [[7ybo]], [[7yc1]], [[7yc3]], [[8w5c]] – hFGFR4 TKD + inhibitor<br />
-
**[[6jpj]], [[5xff]], [[5xfj]] – hFGFR4 TKD (mutant) + inhibitor<br />
+
**[[7tyd]] – hFGFR4 TKD + protein inhibitor<br />
 +
**[[6yi8]] – hFGFR4 TKD + drug<br />
 +
**[[5xff]], [[5xfj]], [[6iuo]], [[6iup]], [[6jpe]], [[6jpj]], [[7v29]], [[7wcw]], [[7wcx]], [[7ybp]], [[7ybx]], [[8kh6]], [[8kh7]], [[8kh8]], [[8kh9]] – hFGFR4 TKD (mutant) + inhibitor<br />
**[[4qrc]], [[4r6v]], [[4qqc]], [[4qq5]], [[4uxq]], [[4xcu]] – hFGFR4 TKD (mutant) + irreversible inhibitor<br />
**[[4qrc]], [[4r6v]], [[4qqc]], [[4qq5]], [[4uxq]], [[4xcu]] – hFGFR4 TKD (mutant) + irreversible inhibitor<br />
 +
*''FGFR4 LBD''
 +
 +
**[[6j6y]] – hFGFR4 LBD D2 + antibody<br />
 +
**[[7n1j]], [[7tyd]] – hFGFR4 LBD D3 + binder<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of fibroblast growth factor receptor

Updated on 03-July-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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