6nef
From Proteopedia
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==Outer Membrane Cytochrome S Filament from Geobacter Sulfurreducens== | ==Outer Membrane Cytochrome S Filament from Geobacter Sulfurreducens== | ||
| - | < | + | <SX load='6nef' size='340' side='right' viewer='molstar' caption='[[6nef]], [[Resolution|resolution]] 3.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6nef]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6nef]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacter_sulfurreducens_PCA Geobacter sulfurreducens PCA]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NEF FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand= | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nef OCA], [https://pdbe.org/6nef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nef RCSB], [https://www.ebi.ac.uk/pdbsum/6nef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nef ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OMCS_GEOSL OMCS_GEOSL] Plays an important role in extracellular electron transfer. Can transfer electrons to insoluble Fe(3+) oxides as well as other extracellular electron acceptors, including Mn(4+) oxide and humic substances (PubMed:16332857, PubMed:20400557, PubMed:21236241). Essential for direct interspecies electron transfer (DIET) in cocultures with G. metallireducens (PubMed:23377933).<ref>PMID:16332857</ref> <ref>PMID:20400557</ref> <ref>PMID:21236241</ref> <ref>PMID:23377933</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Electrically conductive pili from Geobacter species, termed bacterial nanowires, are intensely studied for their biological significance and potential in the development of new materials. Using cryo-electron microscopy, we have characterized nanowires from conductive G. sulfurreducens pili preparations that are composed solely of head-to-tail stacked monomers of the six-heme C-type cytochrome OmcS. The unique fold of OmcS - closely wrapped around a continuous stack of hemes that can serve as an uninterrupted path for electron transport - generates a scaffold that supports the unbranched chain of hemes along the central axis of the filament. We present here, at 3.4 A resolution, the structure of this cytochrome-based filament and discuss its possible role in long-range biological electron transport. | ||
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| + | Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire.,Filman DJ, Marino SF, Ward JE, Yang L, Mester Z, Bullitt E, Lovley DR, Strauss M Commun Biol. 2019 Jun 19;2:219. doi: 10.1038/s42003-019-0448-9. eCollection 2019. PMID:31240257<ref>PMID:31240257</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6nef" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
| - | [[Category: Geobacter sulfurreducens]] | + | [[Category: Geobacter sulfurreducens PCA]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bullitt | + | [[Category: Bullitt E]] |
| - | [[Category: Filman | + | [[Category: Filman DJ]] |
| - | [[Category: Lovley | + | [[Category: Lovley DR]] |
| - | [[Category: Marino | + | [[Category: Marino SF]] |
| - | [[Category: Mester | + | [[Category: Mester Z]] |
| - | [[Category: Strauss | + | [[Category: Strauss M]] |
| - | [[Category: Ward | + | [[Category: Ward JE]] |
| - | [[Category: Yang | + | [[Category: Yang L]] |
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Current revision
Outer Membrane Cytochrome S Filament from Geobacter Sulfurreducens
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