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| | <StructureSection load='5amt' size='340' side='right'caption='[[5amt]], [[Resolution|resolution]] 1.62Å' scene=''> | | <StructureSection load='5amt' size='340' side='right'caption='[[5amt]], [[Resolution|resolution]] 1.62Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5amt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"francisella_tularensis_subsp._novicida"_(larson_et_al._1955)_sjostedt_2005 "francisella tularensis subsp. novicida" (larson et al. 1955) sjostedt 2005]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AMT FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5amt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._novicida Francisella tularensis subsp. novicida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AMT FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5amu|5amu]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5amt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amt OCA], [http://pdbe.org/5amt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5amt RCSB], [http://www.ebi.ac.uk/pdbsum/5amt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5amt ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5amt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5amt OCA], [https://pdbe.org/5amt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5amt RCSB], [https://www.ebi.ac.uk/pdbsum/5amt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5amt ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/A0Q7H2_FRATN A0Q7H2_FRATN] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| | + | [[Category: Francisella tularensis subsp. novicida]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Boraston, A B]] | + | [[Category: Boraston AB]] |
| - | [[Category: Nano, F E]] | + | [[Category: Nano FE]] |
| - | [[Category: Robb, C S]] | + | [[Category: Robb CS]] |
| - | [[Category: Bacterial secretion system]]
| + | |
| - | [[Category: Francisella novicida]]
| + | |
| - | [[Category: Igle]]
| + | |
| - | [[Category: Lipoprotein]]
| + | |
| - | [[Category: Transport protein]]
| + | |
| - | [[Category: Tssj]]
| + | |
| Structural highlights
Function
A0Q7H2_FRATN
Publication Abstract from PubMed
Tularaemia is an uncommon but potentially dangerous zoonotic disease caused by the bacterium Francisella tularensis. As few as ten bacterial cells are sufficient to cause disease in a healthy human, making this one of the most infectious disease agents known. The virulence of this organism is dependent upon a genetic locus known as the Francisella pathogenicity island (FPI), which encodes components of a secretion system that is related to the type VI secretion system. Here, the cloning, expression, purification and preliminary X-ray diffraction statistics of the FPI-encoded protein IglE are presented. This putative lipoprotein is required for intra-macrophage growth and is thought to be a constituent of the periplasmic portion of the type VI-like protein complex that is responsible for the secretion of critical virulence factors in Francisella.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of intracellular growth locus E (IglE) protein from Francisella tularensis subsp. novicida.,Robb CS, Nano FE, Boraston AB Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1596-8., doi: 10.1107/S1744309110034378. Epub 2010 Nov 25. PMID:21139203[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Robb CS, Nano FE, Boraston AB. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of intracellular growth locus E (IglE) protein from Francisella tularensis subsp. novicida. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1596-8., doi: 10.1107/S1744309110034378. Epub 2010 Nov 25. PMID:21139203 doi:http://dx.doi.org/10.1107/S1744309110034378
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