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6pkv

From Proteopedia

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(New page: '''Unreleased structure''' The entry 6pkv is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (09:26, 20 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6pkv is ON HOLD
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==Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry==
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<SX load='6pkv' size='340' side='right' viewer='molstar' caption='[[6pkv]], [[Resolution|resolution]] 4.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6pkv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PKV FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pkv OCA], [https://pdbe.org/6pkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pkv RCSB], [https://www.ebi.ac.uk/pdbsum/6pkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pkv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRPM2_DANRE TRPM2_DANRE] Nonselective, voltage-independent cation channel that mediates Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic N-terminal region causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening.<ref>PMID:30250252</ref>
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Danio rerio]]
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[[Category: Large Structures]]
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[[Category: Borgnia MJ]]
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[[Category: Borschel WF]]
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[[Category: Hsu AL]]
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[[Category: Lander GC]]
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[[Category: Lee S-Y]]
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[[Category: Wu M]]
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[[Category: Yin Y]]

Current revision

Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry

6pkv, resolution 4.30Å

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OCA

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