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6ob6

From Proteopedia

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<StructureSection load='6ob6' size='340' side='right'caption='[[6ob6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='6ob6' size='340' side='right'caption='[[6ob6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ob6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OB6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ob6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OB6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NBM:6-{[(4-nitrophenyl)methyl]sulfanyl}-9-beta-D-ribofuranosyl-9H-purine'>NBM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SLC29A1, ENT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NBM:6-{[(4-nitrophenyl)methyl]sulfanyl}-9-beta-D-ribofuranosyl-9H-purine'>NBM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ob6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ob6 OCA], [http://pdbe.org/6ob6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ob6 RCSB], [http://www.ebi.ac.uk/pdbsum/6ob6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ob6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ob6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ob6 OCA], [https://pdbe.org/6ob6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ob6 RCSB], [https://www.ebi.ac.uk/pdbsum/6ob6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ob6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/S29A1_HUMAN S29A1_HUMAN]] Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
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[https://www.uniprot.org/uniprot/S29A1_HUMAN S29A1_HUMAN] Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lee, S Y]]
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[[Category: Lee S-Y]]
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[[Category: Wright, N J]]
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[[Category: Wright NJ]]
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[[Category: Adenosine reuptake inhibitor]]
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[[Category: Adenosine transport]]
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[[Category: Ent]]
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[[Category: Hent1]]
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[[Category: Nbmpr]]
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[[Category: Nbti]]
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[[Category: Nucleoside transport]]
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[[Category: Nucleoside-drug transport]]
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[[Category: Slc29]]
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[[Category: Transport protein]]
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Current revision

Human equilibrative nucleoside transporter-1, S-(4-nitrobenzyl)-6-thioinosine bound, merohedrally twinned

PDB ID 6ob6

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