6ol3

<table><tr><td colspan='2'>[[6ol3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OL3 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ol3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ol3 OCA], [http://pdbe.org/6ol3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ol3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ol3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ol3 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Adenovirus Virus-Associated (VA) RNAs are the first discovered viral noncoding RNAs. By mimicking double-stranded RNAs (dsRNAs), the exceptionally abundant, multifunctional VA RNAs sabotage host machineries that sense, transport, process, or edit dsRNAs. How VA-I suppresses PKR activation despite its strong dsRNA character, and inhibits the crucial antiviral kinase to promote viral translation, remains largely unknown. Here, we report a 2.7 A crystal structure of VA-I RNA. The acutely bent VA-I features an unusually structured apical loop, a wobble-enriched, coaxially stacked apical and tetra-stems necessary and sufficient for PKR inhibition, and a central domain pseudoknot that resembles codon-anticodon interactions and prevents PKR activation by VA-I. These global and local structural features collectively define VA-I as an archetypal PKR inhibitor made of RNA. The study provides molecular insights into how viruses circumnavigate cellular rules of self vs non-self RNAs to not only escape, but further compromise host innate immunity.

Crystal structure of an adenovirus virus-associated RNA.,Hood IV, Gordon JM, Bou-Nader C, Henderson FE, Bahmanjah S, Zhang J Nat Commun. 2019 Jun 28;10(1):2871. doi: 10.1038/s41467-019-10752-6. PMID:31253805<ref>PMID:31253805</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Bahmanjah, S]]

[[Category: Bou-Nader, C]]

[[Category: Gordon, J M]]

[[Category: Henderson, F V]]

[[Category: Hood, I V]]

[[Category: Zhang, J]]

[[Category: Viral rna]]