1jes

<table><tr><td colspan='2'>[[1jes]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JES FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPY:2-DEOXYRIBOFURANOSYL-PYRIDINE-2,6-DICARBOXYLIC+ACID-5-MONOPHOSPHATE'>DPY</scene>, <scene name='pdbligand=DRP:2-DEOXYRIBOFURANOSYL-PYRIDINE-5-MONOPHOSPHATE'>DRP</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bna|1bna]], [[2zna|2zna]], [[3zna|3zna]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jes OCA], [http://pdbe.org/1jes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jes RCSB], [http://www.ebi.ac.uk/pdbsum/1jes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jes ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.; Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am. Chem. Soc. 2000, 122, 10714-10715). To understand the structural consequences of introducing this novel base pair into DNA we have solved the crystal structure of a duplex containing the metallo-base pair. The structure shows that the bases pair as designed, but in a Z-DNA conformation. The structure also provides a structural explanation for the B- to Z-DNA transition in this duplex. Further solution studies demonstrate that the metallo-base pair is compatible with Z- or B-DNA conformations, depending on the duplex sequence.

Structure of a copper-mediated base pair in DNA.,Atwell S, Meggers E, Spraggon G, Schultz PG J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:11734038<ref>PMID:11734038</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1jes" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Atwell, S]]

[[Category: Meggers, E]]

[[Category: Schultz, P G]]

[[Category: Spraggon, G]]

[[Category: Z-dna]]