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| | <StructureSection load='2w65' size='340' side='right'caption='[[2w65]], [[Resolution|resolution]] 2.21Å' scene=''> | | <StructureSection load='2w65' size='340' side='right'caption='[[2w65]], [[Resolution|resolution]] 2.21Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2w65]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W65 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W65 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2w65]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W65 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21Å</td></tr> |
| - | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2w60|2w60]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w65 OCA], [https://pdbe.org/2w65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w65 RCSB], [https://www.ebi.ac.uk/pdbsum/2w65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w65 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w65 OCA], [http://pdbe.org/2w65 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w65 RCSB], [http://www.ebi.ac.uk/pdbsum/2w65 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w65 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: Bajtner, E]] | + | [[Category: Bajtner E]] |
| - | [[Category: Bockermann, R]] | + | [[Category: Bockermann R]] |
| - | [[Category: Burkhardt, H]] | + | [[Category: Burkhardt H]] |
| - | [[Category: Engstrom, A]] | + | [[Category: Engstrom A]] |
| - | [[Category: Holmdahl, R]] | + | [[Category: Holmdahl R]] |
| - | [[Category: Nandakumar, K S]] | + | [[Category: Nandakumar KS]] |
| - | [[Category: Sehnert, B]] | + | [[Category: Sehnert B]] |
| - | [[Category: Serre, G]] | + | [[Category: Serre G]] |
| - | [[Category: Thunnissen, M M.G M]] | + | [[Category: Thunnissen MMGM]] |
| - | [[Category: Uysal, H]] | + | [[Category: Uysal H]] |
| - | [[Category: Antibody anti-citrullin]]
| + | |
| - | [[Category: Arthritis]]
| + | |
| - | [[Category: Collagen type ii]]
| + | |
| - | [[Category: Immune system]]
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| Structural highlights
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear. To obtain insight into this question, a panel of mouse monoclonal antibodies was generated against a major triple helical collagen type II (CII) epitope (position 359-369; ARGLTGRPGDA) with or without arginines modified by citrullination. These antibodies bind cartilage and synovial tissue, and mediate arthritis in mice. Detection of citrullinated CII from RA patients' synovial fluid demonstrates that cartilage-derived CII is indeed citrullinated in vivo. The structure determination of a Fab fragment of one of these antibodies in complex with a citrullinated peptide showed a surprising beta-turn conformation of the peptide and provided information on citrulline recognition. Based on these findings, we propose that autoimmunity to CII, leading to the production of antibodies specific for both native and citrullinated CII, is an important pathogenic factor in the development of RA.
Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.,Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engstrom A, Serre G, Burkhardt H, Thunnissen MM, Holmdahl R J Exp Med. 2009 Feb 16;206(2):449-62. Epub 2009 Feb 9. PMID:19204106[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engstrom A, Serre G, Burkhardt H, Thunnissen MM, Holmdahl R. Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med. 2009 Feb 16;206(2):449-62. Epub 2009 Feb 9. PMID:19204106 doi:10.1084/jem.20081862
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