1j5i

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==Solution Structure of a Novel Chromoprotein Derived from Apo-Neocarzinostatin and a Synthetic Chromophore==
==Solution Structure of a Novel Chromoprotein Derived from Apo-Neocarzinostatin and a Synthetic Chromophore==
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<StructureSection load='1j5i' size='340' side='right'caption='[[1j5i]], [[NMR_Ensembles_of_Models | 44 NMR models]]' scene=''>
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<StructureSection load='1j5i' size='340' side='right'caption='[[1j5i]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1j5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/'streptomyces_carzinostaticus' 'streptomyces carzinostaticus']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J5I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1j5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J5I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCZ:2-HYDROXY-7-METHOXY-5-METHYL-NAPHTHALENE-1-CARBOXYLIC+ACID+MESO-2,5-DIHYDROXY-CYCLOPENT-3-ENYL+ESTER'>NCZ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 44 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j5i OCA], [http://pdbe.org/1j5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1j5i RCSB], [http://www.ebi.ac.uk/pdbsum/1j5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1j5i ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCZ:2-HYDROXY-7-METHOXY-5-METHYL-NAPHTHALENE-1-CARBOXYLIC+ACID+MESO-2,5-DIHYDROXY-CYCLOPENT-3-ENYL+ESTER'>NCZ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j5i OCA], [https://pdbe.org/1j5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j5i RCSB], [https://www.ebi.ac.uk/pdbsum/1j5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j5i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
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[https://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Streptomyces carzinostaticus]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Caddick, S]]
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[[Category: Streptomyces carzinostaticus]]
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[[Category: Finucane, M D]]
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[[Category: Caddick S]]
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[[Category: Muskett, F W]]
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[[Category: Finucane MD]]
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[[Category: Urbaniak, M D]]
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[[Category: Muskett FW]]
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[[Category: Woolfson, D N]]
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[[Category: Urbaniak MD]]
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[[Category: Antibiotic]]
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[[Category: Woolfson DN]]
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[[Category: Beta sandwich]]
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[[Category: Chromophore]]
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[[Category: Igg fold]]
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[[Category: Ligand]]
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Current revision

Solution Structure of a Novel Chromoprotein Derived from Apo-Neocarzinostatin and a Synthetic Chromophore

PDB ID 1j5i

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