Glutamate racemase

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Current revision (08:51, 11 July 2019) (edit) (undo)
 
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== 3D Structures of glutamate racemase ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Glutamate racemate
 
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**[[1b73]], [[1b74]] – GR – ''Aquifex pyrophilus'' <BR />
 
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**[[2gzm]], [[2dwu]] – GR – ''Bacillus anthracis'' <BR />
 
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**[[2ohg]], [[2oho]] – SpGR – ''Streptococcus pyogenes'' <BR />
 
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**[[3hfr]] – LmGR – ''Listeria monocytogenes'' <BR />
 
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**[[3uhp]] – CjGR – ''Campylobacter jejuni'' <BR />
 
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*Glutamate racemate complexes
 
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**[[2jfn]] – GR + UDP-acetylmuramoyl-alanine + glutamate – ''Escherichia coli '' <BR />
 
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**[[2jfo]], [[2jfp]] – EfGR + D-glutamate – ''Enterococcus faecalis'' <BR />
 
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**[[2jfq]] – GR + D-glutamate – ''Staphylococcus aureus'' <BR />
 
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**[[3out]] – GR + D-glutamate – ''Francisella tularensis'' <BR />
 
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**[[1zuw]] – GR + D-glutamate – ''Bacillus subtilis'' <BR />
 
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**[[3uhf]], [[3uho]] – CjGR + D-glutamate <BR />
 
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**[[2jfu]] – EfGR + phosphate <BR />
 
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**[[2jfv]] – EfGR + citrate <BR />
 
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**[[2jfw]] – EfGR + tartrate <BR />
 
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**[[2vvt]] – EfGR + inhibitor <BR />
 
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**[[3ist]] – LmGR + succinate <BR />
 
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**[[3isv]] – LmGR + acetate <BR />
 
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**[[2jfx]], [[2jfy]], [[5w1q]] – HpGR + D-glutamate – ''Helicobacter pylori '' <BR />
 
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**[[2jfz]], [[2w4i]], [[4b1f]] – HpGR + D-glutamate + inhibitor <BR />
 
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**[[2ohv]] – SpGR + D-glutamate derivative inhibitor <BR />
 
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**[[5hj7]] – GR + D-glutamate – ''Mycobacterium tuberculosis''<BR />
 
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**[[5ijw]] – GR + D-glutamate – ''Mycobacterium smegmatis''<BR />
 
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**[[6dli]] – TtGR + alanine derivative - ''Thermus thermophilus''<BR />
 
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**[[5w16]] – TtGR + D-glutamate <BR />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of glutamate racemase dimer complex with D-glutamate and inhibitor (PDB entry 2jfz)

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References

  1. ↑ Sengupta S, Ghosh S, Nagaraja V. Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme. Microbiology. 2008 Sep;154(Pt 9):2796-803. doi: 10.1099/mic.0.2008/020933-0. PMID:18757813 doi:http://dx.doi.org/10.1099/mic.0.2008/020933-0
  2. ↑ Basarab GS, Hill P, Eyermann CJ, Gowravaram M, Kack H, Osimoni E. Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: Incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5600-7. Epub 2012 Jul 20. PMID:22877632 doi:http://dx.doi.org/10.1016/j.bmcl.2012.07.004
  3. ↑ Lundqvist T, Fisher SL, Kern G, Folmer RH, Xue Y, Newton DT, Keating TA, Alm RA, de Jonge BL. Exploitation of structural and regulatory diversity in glutamate racemases. Nature. 2007 Jun 14;447(7146):817-22. PMID:17568739 doi:http://dx.doi.org/10.1038/nature05689

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Michal Harel, Alexander Berchansky

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