Metabotropic glutamate receptor
From Proteopedia
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<scene name='46/464134/Cv/3'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules are shown as red spheres. | <scene name='46/464134/Cv/3'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules are shown as red spheres. | ||
| - | </StructureSection> | ||
==3D structures of metabotropic glutamate receptor == | ==3D structures of metabotropic glutamate receptor == | ||
| + | [[Metabotropic glutamate receptor 3D structures]] | ||
| - | + | </StructureSection> | |
| - | + | ||
| - | *Metabotropic glutamate receptor 1 | ||
| - | |||
| - | **[[1ewt]], [[1ewv]] - rMGluR1 LBD - rat<br /> | ||
| - | **[[3ks9]] – hMGluR1 (mutant) + antagonist - human<br /> | ||
| - | **[[4or2]] - hMGluR1/cytochrome b526<br /> | ||
| - | **[[1isr]], [[1ewk]] – rMGluR1 LBD + Glu<br /> | ||
| - | **[[1iss]] - rMGluR1 LBD + antagonist<br /> | ||
| - | |||
| - | *Metabotropic glutamate receptor 2 | ||
| - | |||
| - | **[[4xas]], [[4xaq]] – hMGluR2 LBD + agonist<br /> | ||
| - | **[[5kzq]], [[5kzn]] – hMGluR2 LBD + antagonist<br /> | ||
| - | **[[5cni]] – hMGluR2 LBD + Glu <br /> | ||
| - | **[[5cnj]] – hMGluR2 LBD + Glu analog<br /> | ||
| - | |||
| - | *Metabotropic glutamate receptor 3 | ||
| - | |||
| - | **[[5cnk]] – hMGluR3 LBD + Glu <br /> | ||
| - | **[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br /> | ||
| - | **[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br /> | ||
| - | **[[3sm9]] - hMGluR3 + antagonist<br /> | ||
| - | **[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br /> | ||
| - | **[[5cnm]] – hMGluR3 LBD + Glu analog<br /> | ||
| - | |||
| - | *Metabotropic glutamate receptor 5 | ||
| - | |||
| - | **[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br /> | ||
| - | **[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br /> | ||
| - | **[[5cgc]], [[5cgd]] - hMGluR5 transmembrane domain + negative allosteric modulator<br /> | ||
| - | |||
| - | *Metabotropic glutamate receptor 7 | ||
| - | |||
| - | **[[5c5c]] – hMGluR7 LBD (mutant)<br /> | ||
| - | **[[3mq4]] – hMGluR7 LBD + antagonist<br /> | ||
| - | |||
| - | *Metabotropic glutamate receptor 8 | ||
| - | |||
| - | **[[6bsz]] – hMGluR8 LBD + Glu <br /> | ||
| - | **[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br /> | ||
| - | }} | ||
==See Also== | ==See Also== | ||
[[Membrane Channels & Pumps]] <br/> | [[Membrane Channels & Pumps]] <br/> | ||
| - | [[ | + | [[Ionotropic Glutamate Receptors]]<br/> |
[[Alzheimer's Disease]]<br/> | [[Alzheimer's Disease]]<br/> | ||
| - | + | * [[G protein-coupled receptor]] | |
| + | *[[Receptor]] | ||
| + | *[[Transmembrane (cell surface) receptors]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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See Also
Membrane Channels & Pumps
Ionotropic Glutamate Receptors
Alzheimer's Disease
References
- ↑ Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 2010 Sep;62(3):405-96. doi: 10.1124/pr.109.002451. PMID:20716669 doi:http://dx.doi.org/10.1124/pr.109.002451
- ↑ Johnson KA, Conn PJ, Niswender CM. Glutamate receptors as therapeutic targets for Parkinson's disease. CNS Neurol Disord Drug Targets. 2009 Dec;8(6):475-91. PMID:19702565
- ↑ Niswender CM, Conn PJ. Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol. 2010;50:295-322. doi:, 10.1146/annurev.pharmtox.011008.145533. PMID:20055706 doi:http://dx.doi.org/10.1146/annurev.pharmtox.011008.145533
- ↑ Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature. 2000 Oct 26;407(6807):971-7. PMID:11069170 doi:10.1038/35039564
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