Glutathione S-transferase
From Proteopedia
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== Function == | == Function == | ||
'''Glutathione S-transferase''' (GST) catalyzes the conjugation of reduced glutathione (GSH) to a variety of exogenous and endogenous hydrophobic electrophiles. For example, GST can detoxify peroxidised lipids. All eukaryotes possess a variety of GSTs with catalytic and non-catalytic activities. GST is divided into classes: α, δ, ε, κ, μ, ν, ω, π, ρ, σ (hematopoietic prostaglandin D synthase), τ, χ, ϑ, ζ and microsomal<ref>PMID:21428697</ref>. | '''Glutathione S-transferase''' (GST) catalyzes the conjugation of reduced glutathione (GSH) to a variety of exogenous and endogenous hydrophobic electrophiles. For example, GST can detoxify peroxidised lipids. All eukaryotes possess a variety of GSTs with catalytic and non-catalytic activities. GST is divided into classes: α, δ, ε, κ, μ, ν, ω, π, ρ, σ (hematopoietic prostaglandin D synthase), τ, χ, ϑ, ζ and microsomal<ref>PMID:21428697</ref>. | ||
| + | *'''epsilon glutathione S-transferase''' has a role in insecticide resistance<ref>PMID:26487708</ref>. | ||
| + | *'''kappa glutathione S-transferase''' is found in mitochondria and peroxisomes. It may be involved in lipid metabolism<ref>PMID:21428694</ref>. | ||
| + | *'''mu glutathione S-transferase''' detoxify carcinogens in tobacco smoke<ref>PMID:8485718</ref>. | ||
| + | *'''nu glutathione S-transferase''' breaks the beta-aryl ether bond of lignin<ref>PMID:29449375</ref>. | ||
| + | *'''pi glutathione S-transferase''' has a role in carcinogenic processes<ref>PMID:9679544</ref>. | ||
| + | *'''rho glutathione S-transferase''' detoxifies water from the pollutant dichloroacetate<ref>PMID:25685659</ref>. | ||
| + | *'''sigma glutathione S-transferase''' is a detoxifying agent providing drug resistance and acting as vaccine antigen<ref>PMID:38668546</ref>. | ||
| + | *'''omega glutathione S-transferase''' catalyzes a range of thiol transferase reactions like biotransformation of haloketones to nontoxic acetophenones<ref>PMID:21495794</ref>. | ||
| + | *'''zeta glutathione S-transferase''' catalyzes the reaction of glutathione with Endo- and xenobiotics<ref>PMID:21303221</ref>. | ||
| + | *'''tau glutathione S-transferase''' and '''LanCL1 glutathione S-transferase''' are involved in oxidative stress response<ref>PMID:15037622</ref>. | ||
| + | *'''phi glutathione S-transferase''' is plant-specific<ref>PMID:26884677</ref>. | ||
| + | *'''microsomali glutathione S-transferase''' protects cells from cytostatic drugs and from oxidative stress<ref>PMID:21495795</ref>. | ||
==Relevance== | ==Relevance== | ||
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of glutathione S-transferase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *GST | ||
| - | |||
| - | **[[1gsb]], [[1gsc]] – rGST – rat<br /> | ||
| - | **[[3vwx]] – GST 6B (mutant) – fly<br /> | ||
| - | **[[3f6f]] – DmGST – Drosophila melanogaster <br /> | ||
| - | **[[3w8s]] – hoGST 3 – hookworm<br /> | ||
| - | **[[4ofm]], [[4ofn]], [[4oft]] – hoGST 1<br /> | ||
| - | **[[3ay8]], [[4e8e]] - siGST – silkworm<br /> | ||
| - | **[[1aw9]] - cGST III – corn<br /> | ||
| - | **[[4j2f]] – GST – castor bean<br /> | ||
| - | **[[3erf]] - yGST II – yeast<br /> | ||
| - | **[[3ubk]] – LiGST – ''Leptospira interrogans''<br /> | ||
| - | **[[3uap]] - McGST – ''Methylococcus capsulatus''<br /> | ||
| - | **[[1okt]], [[4zxg]] – PfGST – ''Plasmodium falciparum''<br /> | ||
| - | **[[3fr6]] - PfGST (mutant) <br /> | ||
| - | **[[1tw9]] – GST - ''Heligmosomoides polygyrus''<br /> | ||
| - | **[[1yq1]] - CeGST – ''Caenorhabditis elegans''<br /> | ||
| - | **[[1y6e]] - SjGST – ''Schistosoma japonicum''<br /> | ||
| - | **[[2fno]], [[3lq7]] - AtGST – ''Agrobacterium tumefaciens''<br /> | ||
| - | **[[2on7]] – NaGST-1 – ''Necator americanus''<br /> | ||
| - | **[[3f6f]] – DmGST – ''Drosophila melanogaster''<br /> | ||
| - | **[[3lxt]] - PsfGST – ''Pseudomonas fluorescens''<br /> | ||
| - | **[[4eci]] - PaGST – ''Pseudomonas aeruginosa''<br /> | ||
| - | **[[3niv]] - GST – ''Legionella pneumophila''<br /> | ||
| - | **[[3tot]] - RsGST – ''Ralstonia solanacearum''<br /> | ||
| - | **[[3ay8]], [[4e8e]] - siGST – silkworm<br /> | ||
| - | **[[1jlw]] - AcGST - ''Anopheles cracens''<br /> | ||
| - | **[[4f03]] - PcGST - ''Phanerochaete chrysosporium''<br /> | ||
| - | **[[4mp4]] – GST – ''Acinetobacter baumannii''<br /> | ||
| - | **[[4o7h]] – GST – ''Rhodospirillum rubrum''<br /> | ||
| - | **[[4o92]] – GST – ''Pichia kudriavzevii''<br /> | ||
| - | **[[4mf7]] – GST – ''Bradyrhizobium''<br /> | ||
| - | **[[4n0v]] – GST N terminal – ''Marinobacter aquaeolei''<br /> | ||
| - | **[[4pts]] – GST – ''Gordonia bronchialis''<br /> | ||
| - | **[[5el8]], [[5ela]], [[5elg]] - AtGST DHAR1 – ''Arabidopsis thaliana''<br /> | ||
| - | **[[4hz4]] – GST – ''Actinobacillus pleuropneumoniae''<br /> | ||
| - | |||
| - | *''GST binary complex with GSH'' | ||
| - | |||
| - | **[[1m0u]], [[3gh6]] - DmGST + GSH<BR /> | ||
| - | **[[5an1]] – GST + GSH – shrimp<br /> | ||
| - | **[[1oyj]] - GST + GSH - rice<br /> | ||
| - | **[[3ibh]] - yGST II + GSH<BR /> | ||
| - | **[[2x64]] – GST + GSH – ''Xylella fastidiosa''<br /> | ||
| - | **[[4hz2]] - GST + GSH - ''Xanthobacter autotrophicus''<br /> | ||
| - | **[[4ecj]] - PaGST + GSH<BR /> | ||
| - | **[[1fhe]], [[2fhe]] - FhGST + GSH – ''Fasciola hepatica''<br /> | ||
| - | **[[1pmt]], [[2pmt]] - GST + GSH – ''Proteus mirabilis''<br /> | ||
| - | **[[1oe7]], [[1oe8]] - ShGST + GSH – ''Schistosoma haematobium''<br /> | ||
| - | **[[1u3i]] - GST + GSH - ''Schistosoma mansoni''<br /> | ||
| - | **[[1u87]], [[1gne]] - SjGST + GSH<BR /> | ||
| - | **[[2dsa]], [[2gdr]] - GST + GSH – ''Burkholderia xenovorans''<br /> | ||
| - | **[[4isd]] - GST + GSH – ''Burkholderia glumae''<br /> | ||
| - | **[[2on5]] – NaGST-2 + GSH<BR /> | ||
| - | **[[2nto]] - OaGST + GSH – ''Ochrobactrum anthropi''<br /> | ||
| - | **[[2pvq]] - OaGST (mutant) + GSH<BR /> | ||
| - | **[[3fr9]] - PfGST + GSH<BR /> | ||
| - | **[[3m3m]] - PsfGST + GSH<BR /> | ||
| - | **[[3lsz]] - GST + GSH – ''Rhodobacter sphaeroides''<br /> | ||
| - | **[[3n5o]] - GST + GSH – ''Coccidioides immitis''<br /> | ||
| - | **[[3tou]], [[4kf9]] - RsGST + GSH<BR /> | ||
| - | **[[3uar]] - McGST + GSH<BR /> | ||
| - | **[[4g9h]], [[4gci]] - GST + GSH – ''Yersinia pestis''<br /> | ||
| - | **[[4gf0]] - GST + GSH - ''Sulfitobacter''<br /> | ||
| - | **[[1jlv]] - AcGST + GSH<br /> | ||
| - | **[[4g19]] - PcGST + GSH<br /> | ||
| - | **[[4ikh]] – GST + GSH – ''Pseudomonas protegens''<br /> | ||
| - | **[[4jed]] – GST + GSH – ''Methylobacter radiotolerans''<br /> | ||
| - | **[[4kgi]] – GST + GSH – ''Shigella flexneri''<br /> | ||
| - | **[[4kh7]] – GST + GSH – ''Salmonella enterica''<br /> | ||
| - | **[[4mk3]] – GST + GSH derivative – ''Cupriavidus metallidurans''<br /> | ||
| - | **[[4nhw]] – GST + GSH – ''Sinorhizobium meliloti''<br /> | ||
| - | **[[4l8e]] – GST + GSH – ''Xenorhabdus nematophila''<br /> | ||
| - | **[[4nax]] – GST N terminal + GSH – ''Pseudomonas putida''<br /> | ||
| - | **[[4pua]] – GST + GSH – ''Streptococcus pneumoniae''<br /> | ||
| - | **[[5lol]] - AtGST DHAR2 + GSH<br /> | ||
| - | |||
| - | *''GST binary complex'' | ||
| - | |||
| - | **[[1aqv]] - hGST + GSH derivative – human<br /> | ||
| - | **[[2gsq]] – sqGST + GSH derivative – squid<br /> | ||
| - | **[[2gst]], [[3gst]], [[4gst]], [[5gst]], [[1gss]]. [[1mtc]] - rGST + GSH derivative<br /> | ||
| - | **[[1bye]] - cGST I + herbicide <br /> | ||
| - | **[[1axd]] – cGST I + lactoyl-GSH<BR /> | ||
| - | **[[3erg]] - yGST II + GSH derivative<br /> | ||
| - | **[[3qmz]] - yGST + dynein heavy chain<br /> | ||
| - | **[[1gnw]], [[2ycd]] - AtGST + GSH derivative <br /> | ||
| - | **[[5a4u]] - AtGST + indole aldehyde<br /> | ||
| - | **[[5a4v]], [[5a4w]] - AtGST + quercetin<br /> | ||
| - | **[[5a5k]] - AtGST + camalexin<br /> | ||
| - | **[[1bx9]] - AtGST + herbicide<br /> | ||
| - | **[[1gtb]], [[1gta]] - SjGST + praziquantel<br /> | ||
| - | **[[1m99]], [[1m9a]], [[1m9b]]. [[1ua5]] - SjGST + GSH derivative<br /> | ||
| - | **[[1u88]] - SjGST (mutant) + GSH derivative<br /> | ||
| - | **[[1q4j]], [[2aaw]], [[3frc]] - PfGST + GSH derivative<br /> | ||
| - | **[[3fr3]] - PfGST (mutant) + GSH derivative<br /> | ||
| - | **[[1a0f]], [[1n2a]] - GST + GSH derivative – ''Eschericia coli''<br /> | ||
| - | **[[1f2e]] - GST + GSH derivative – ''Sphingomonas paucimobilis''<br /> | ||
| - | **[[4yav]] - GST + GSH derivative – ''Sphingobium''<br /> | ||
| - | **[[3ubl]] - LiGST + GSH derivative<br /> | ||
| - | |||
| - | *GST α class | ||
| - | |||
| - | **[[1guh]], [[1gsd]], [[1k3o]], [[1pkz]] – hGST A1-1<br /> | ||
| - | **[[1xwg]], [[3q74]], [[3u6v]], [[3zfb]], [[3zfl]] - hGST A1-1 (mutant) <br /> | ||
| - | **[[1gum]] - hGST A4-4<br /> | ||
| - | **[[1guk]] - mGST A4-4 – mouse<br /> | ||
| - | **[[1vf4]] - GgGST A1-1 - chicken | ||
| - | |||
| - | *''GST α class complex with GSH'' | ||
| - | |||
| - | **[[1pkw]] - hGST + GSH<BR /> | ||
| - | **[[1usb]] - hGST (mutant) + GSH<BR /> | ||
| - | **[[1f3a]] - mGST A1-1+ GSH<BR /> | ||
| - | **[[3i69]], [[3i6a]] - hGST A1-1 (mutant)+ GSH<BR /> | ||
| - | **[[2wju]] - hGST A2-2 + GSH<BR /> | ||
| - | **[[4acs]] - hGST A2-2 (mutant) + GSH<BR /> | ||
| - | **[[1tdi]] - hGST A3-3 + GSH<BR /> | ||
| - | **[[1vf1]] - GgGST A1-1 + GSH<BR /> | ||
| - | |||
| - | *''GST α class complex'' | ||
| - | |||
| - | **[[1gsf]] – hGST A1-1 + ethacrynic acid<br /> | ||
| - | **[[1ags]], [[1pl2]], [[1ydk]], [[2r3x]], [[2r6k]], [[3ktl]], [[3l0h]] – hGST (mutant) + GSH derivative<br /> | ||
| - | **[[1k3l]], [[1k3y]], [[1pl1]] - hGST + GSH derivative<br /> | ||
| - | **[[1gse]] – hGST (mutant) + GSH + ethacrynic acid<br /> | ||
| - | **[[3ik9]] - hGST A1-1 + GSDN<br /> | ||
| - | **[[4hj2]] - hGST A1-1 + chemotherapeutic drug<br /> | ||
| - | **[[5jcu]] - hGST A1-1 + inhibitor<br /> | ||
| - | **[[2vct]] - hGST A2-2 + steroid<br /> | ||
| - | **[[2vcv]] - hGST A3-3 + steroid<br /> | ||
| - | **[[1gul]] - hGST A4-4+ iodobenzyl-GSH<BR /> | ||
| - | **[[3ik7]] - hGST A4-4 + GSDHN <br /> | ||
| - | **[[1b48]] - mGST A4-4 + GSH derivative<br /> | ||
| - | **[[1f3b]] - mGST A1-1 + GSH derivative<br /> | ||
| - | **[[1ml6]] - mGST A2-2+ GSH derivative<br /> | ||
| - | **[[1ev4]], [[1ev9]] - rGST A1-1 (mutant) + GSH derivative<br /> | ||
| - | **[[1vf2]], [[1vf3]] – GgGST A1-1 + GSH derivative<br /> | ||
| - | |||
| - | *GST δ class | ||
| - | |||
| - | **[[1r5a]], [[1v2a]], [[1pn9]] - AcGST + GSH derivative <br /> | ||
| - | **[[3f63]], [[3g7i]] - AdGST + GSH derivative - ''Anopheles dirus''<br /> | ||
| - | **[[3f6d]], [[3g7j]] - AdGST )mutant) + GSH derivative<br /> | ||
| - | **[[3ein]] - DmGST + GSH<BR /> | ||
| - | **[[3vk9]] - siGST <br /> | ||
| - | **[[4i97]] – GST + GSH – ''Scaptomyza nigrita''<br /> | ||
| - | **[[3wyw]] – GST + GSH – brown planthopper<br /> | ||
| - | **[[5f0g]] – DmGST-2 <br /> | ||
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| - | *GST ε class | ||
| - | |||
| - | **[[2il3]] - AgGST – ''Anopheles gambiae''<br /> | ||
| - | **[[2imi]] - AgGST + GSH<BR /> | ||
| - | **[[2imk]], [[4gsn]] - AgGST + GSH derivative<br /> | ||
| - | **[[3zmk]], [[3zml]] - GST + GSH – ''Anopheles funestus''<br /> | ||
| - | **[[5ft3]] - GST + GSH – ''Aedes aegypti''<br /> | ||
| - | **[[4yh2]] - DmGST + GSH <br /> | ||
| - | **[[5ld0]], [[5lcz]] – hGST/rGST<br /> | ||
| - | |||
| - | *GST κ class | ||
| - | |||
| - | **[[3rpp]] - hGST <br /> | ||
| - | **[[1r4w]] - rGST + GSH derivative<br /> | ||
| - | **[[1yzx]], [[3rpn]] - hGST + GSH derivative<br /> | ||
| - | |||
| - | *GST μ class | ||
| - | |||
| - | **[[1gsb]], [[1gsc]] – rGST<br /> | ||
| - | **[[6gsu]], [[6gsv]], [[6gsw]], [[6gsx]], [[6gsy]], [[5fwg]], [[3fyg]] - rGST (mutant) <br /> | ||
| - | **[[1gtu]], [[2gtu]], [[3gtu]], [[4gtu]] - hGST<br /> | ||
| - | **[[2dc5]] - mGST <br /> | ||
| - | **[[2wrt]] - FhGST | ||
| - | |||
| - | *''GST μ class complex with GSH'' | ||
| - | |||
| - | **[[1xw5]], [[1xw6]] - hGST + GSH<BR /> | ||
| - | **[[2f8f]] - mGST (mutant) + GSH<BR /> | ||
| - | **[[3crt]], [[4wr4]], [[4wr5]] - SjGST + GSH<BR /> | ||
| - | **[[3cru]], [[3d0z]] - SjGST (mutant) + GSH<BR /> | ||
| - | **[[6gst]] - rGST + GSH<br /> | ||
| - | **[[4q5q]] – GST + GSH – dust mite<br /> | ||
| - | |||
| - | *''GST μ class complex'' | ||
| - | |||
| - | **[[1c72]] - GgGST + conjugate<br /> | ||
| - | **[[1hna]], [[1hnb]], [[1hnc]], [[1xwk]], [[1ykc]], [[1yj6]], [[2ab6]], [[2f3m]] – hGST + GSH derivative<br /> | ||
| - | **[[1xwk]], [[1yj6]], [[2f3m]] – hGST-1 + GSH derivative<br /> | ||
| - | **[[1ykc]], [[2ab6]] – hGST-2 + GSH derivative<br /> | ||
| - | **[[2c4j]] - hGST-2 (mutant) + GSH derivative<br /> | ||
| - | **[[1b4p]] - rGST + GSH derivative<br /> | ||
| - | **[[3gur]] - hGST-2 + GSH + drug<br /> | ||
| - | **[[5hwl]] – hGST-2 + GSH + acetamide derivative<br /> | ||
| - | **[[1gsu]] - cGST + GSH derivative<br /> | ||
| - | **[[4ai6]], [[4akg]] – SjGST + ATP + ADP<br /> | ||
| - | **[[4aki]] – SjGST + ATP<br /> | ||
| - | **[[4akh]] – SjGST + AMPPNP <br /> | ||
| - | **[[5gzz]] – SjGST + JAR1 + GSH <br /> | ||
| - | |||
| - | *GST ν class | ||
| - | |||
| - | **[[2ws2]] - GST – ''Haemonchus contortus''<br /> | ||
| - | **[[4mzw]] – GST + GSH derivative – ''Streptococcus sanguinis''<br /> | ||
| - | |||
| - | *GST π class | ||
| - | |||
| - | **[[1bay]] - mGST <br /> | ||
| - | **[[10gs]], [[14gs]], [[16gs]], [[1lbk]], [[5dak]], [[5dal]], [[5dcg]], [[5djm]] - hGST<br /> | ||
| - | **[[22gs]], [[1eog]], [[1eoh]], [[3hjm]], [[3hkr]], [[3kmn]] - hGST (mutant)<br /> | ||
| - | **[[5djl]] – hGST + GSH <br /> | ||
| - | **[[5ddl]] – hGST + GSH + GSH derivative <br /> | ||
| - | **[[4ecb]], [[4ecc]] – SjGST/hKininogen peptide<br /> | ||
| - | |||
| - | *''GST π class complex with GSH'' | ||
| - | |||
| - | **[[1gsy]] - mGST + GSH<BR /> | ||
| - | **[[1tu7]], [[2hnl]] - OvGST + GSH - ''Onchocerca volvulus''<br /> | ||
| - | **[[5gss]], [[6gss]], [[7gss]], [[8gss]], [[19gs]], [[3dd3]] - hGST + GSH<BR /> | ||
| - | **[[5jcw]] - hGST + GSH + phenethyl isocyanate<br /> | ||
| - | **[[1md3]], [[1md4]], [[1px6]], [[1px7]], [[1kbn]] - hGST (mutant) + GSH<br /> | ||
| - | **[[5l6x]] - hGST (mutant) + GSH derivative<br /> | ||
| - | **[[5d73]] - GST + GSH – ''Wuchereria bancrofti'' | ||
| - | |||
| - | *''GST π class complex'' | ||
| - | |||
| - | **[[1gss]] – rGST + GSH derivative<br /> | ||
| - | **[[1tu8]] - OvGST + GSH derivative<br /> | ||
| - | **[[1glq]], [[1glp]], [[2glr]], [[1gti]] - mGST + GSH derivative<br /> | ||
| - | **[[2oac]], [[2oad]], [[2oa7]], [[3o76]] - mGST (mutant) + GSH derivative<br /> | ||
| - | **[[2gss]], [[3dgq]] – hGST + ethacrynic acid<br /> | ||
| - | **[[3n9j]] - hGST + ethacrynic acid derivative<br /> | ||
| - | **[[3gss]], [[11gs]] – hGST + ethacrynic acid + GSH<BR /> | ||
| - | **[[3hjo]], [[3km6]], [[3kmo]] - hGST (mutant) + ethacrynic acid + GSH<BR /> | ||
| - | **[[1pgt]], [[2pgt]], [[4gss]], [[17gs]], [[2j9h]], [[3csi]] - hGST (mutant) + GSH derivative<br /> | ||
| - | **[[1aqw]], [[1aqx]], [[9gss]], [[12gs]], [[18gs]], [[3pgt]], [[4pgt]], [[1zgn]], [[2a2r]], [[2a2s]], [[3csh]] - hGST + GSH derivative<br /> | ||
| - | **[[20gs]] - hGST + cibacron blue<br /> | ||
| - | **[[13gs]], [[3csj]], [[1gus]] - hGST + drug<br /> | ||
| - | **[[3ie3]] - hGST (mutant) + drug<br /> | ||
| - | **[[5x79]] – hGST + inhibitor <br /> | ||
| - | **[[5j41]] – hGST + piperlongumine + GSH <br /> | ||
| - | **[[2gsr]] - GST + GSH derivative - pig | ||
| - | |||
| - | *GST ρ class | ||
| - | |||
| - | **[[3qav]] - AcGST – Atlantic clam<br /> | ||
| - | **[[3qaw]] - AcGST + GSH<BR /> | ||
| - | |||
| - | *GST σ class | ||
| - | |||
| - | **[[2c8u]], [[2cai]] - ShGST (mutant) <br /> | ||
| - | **[[3vpt]], [[4e8h]] – siGST <br /> | ||
| - | **[[2ca8]] - ShGST + GSH<BR /> | ||
| - | **[[2wb9]] - FhGST + GSH<br /> | ||
| - | **[[2wdu]] - FhGST + GSH + GSH derivative<br /> | ||
| - | **[[1zl9]] - CeGST + GSH<BR /> | ||
| - | **[[1iyh]], [[1iyi]] - hGST + GSH<BR /> | ||
| - | **[[3vi7]] - hGST (mutant) + GSH<BR /> | ||
| - | **[[1v40]], [[2cvd]], [[3ee2]], [[3kxo]], [[4ec0]], [[4edz]], [[4ee0]], [[4edy]], [[2vcq]], [[2vcw]], [[2vcx]], [[2vcz]], [[2vd0]], [[2vd1]] - hGST + GSH + inhibitor<br /> | ||
| - | **[[3vi5]], [[3vi7]] - hGST (mutant) + GSH + inhibitor<br /> | ||
| - | **[[4imn]] – hGST + PEG<br /> | ||
| - | **[[4imo]] – hGST + substrate analog<br /> | ||
| - | **[[2caq]] - ShGST (mutant) + GSH<BR /> | ||
| - | **[[1pd2]] - rGST + GSH<BR /> | ||
| - | **[[2c80]] - ShGST + GSH derivative<br /> | ||
| - | **[[1gsq]] - sqGST + GSH derivative<br /> | ||
| - | **[[3vpq]] – siGST + GSH<br /> | ||
| - | **[[3vur]] – siGST + GSH derivative<br /> | ||
| - | **[[4q5f]] – GST + GSH – pig roundworm<br /> | ||
| - | **[[4q5r]] – GST + GSH – cockroach<br /> | ||
| - | |||
| - | *GST ϑ class | ||
| - | |||
| - | **[[2ljr]], [[2c3n]], [[4mpf]] - hGST <br /> | ||
| - | **[[2c3t]] - hGST (mutant) <br /> | ||
| - | **[[1ljr]], [[4mpg]] - hGST + GSH<BR /> | ||
| - | **[[3mak]] - DmGST + GSH<BR /> | ||
| - | **[[3ljr]] - hGST + GSH derivative<br /> | ||
| - | **[[2c3q]] - hGST (mutant) + GSH derivative<br /> | ||
| - | |||
| - | *GST χ class | ||
| - | |||
| - | **[[3ppu]] - PcGST + GSH | ||
| - | |||
| - | *GST ω class | ||
| - | |||
| - | **[[1eem]] – hGST<br /> | ||
| - | **[[3vln]], [[4is0]] – hGST-1 (mutant)<br /> | ||
| - | **[[3lfl]] – hGST-1 + GSH <br /> | ||
| - | **[[4yqm]], [[4yqu]], [[4yqv]], [[5v3q]], [[5ueh]] – hGST-1 + inhibitor<br /> | ||
| - | **[[3qag]], [[3q19]] – hGST-2 (mutant) + GSH <br /> | ||
| - | **[[3q18]] – hGST-2 (mutant)<br /> | ||
| - | **[[3wd6]] – GST + GSH – silk moth<br /> | ||
| - | **[[3rbt]] - siGST <br /> | ||
| - | |||
| - | *GST ζ class | ||
| - | |||
| - | **[[1e6b]] – AtGST<br /> | ||
| - | **[[2cz3]] - mGST <br /> | ||
| - | **[[2cz2]] - mGST + GSH<BR /> | ||
| - | **[[1fw1]] - hGST + GSH | ||
| - | |||
| - | *GST τ class | ||
| - | |||
| - | **[[1gwc]] - GST – wheat<br /> | ||
| - | **[[5g5e]] - MiGST – ''Mangifera indica''<br /> | ||
| - | **[[5g5f]] - MiGST + GSH<br /> | ||
| - | **[[5kej]] - MiGST + GSH derivative<br /> | ||
| - | **[[2vo4]], [[4chs]] - sGST + GSH derivative – soybean<br /> | ||
| - | **[[5agy]] - sGST (mutant) + GSH derivative<br /> | ||
| - | **[[4top]] - sGST + GSH<BR /> | ||
| - | **[[6ep6]], [[5o84]] – AtGST <br /> | ||
| - | **[[5ecs]], [[6ep7]] – AtGST + GSH <br /> | ||
| - | **[[5g5a]] - AtGST + GSH derivative<br /> | ||
| - | **[[5ech]], [[5eci]], [[5eck]], [[5ecl]], [[5ecm]], [[5ecn]], [[5eco]] [[5ecp]], [[5ecq]], [[5ecr]] – AtGST + JAR1 + GSH + ATP <br /> | ||
| - | |||
| - | *Microsomal GST | ||
| - | **[[2h8a]], [[5i9k]] - rGST + GSH<BR /> | ||
| - | **[[5ia9]] - rGST + GSH derivative<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Oakley A. Glutathione transferases: a structural perspective. Drug Metab Rev. 2011 May;43(2):138-51. doi: 10.3109/03602532.2011.558093. Epub, 2011 Mar 23. PMID:21428697 doi:http://dx.doi.org/10.3109/03602532.2011.558093
- ↑ Wongsantichon J, Robinson RC, Ketterman AJ. Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site. Biosci Rep. 2015 Oct 20;35(6). pii: e00272. doi: 10.1042/BSR20150183. PMID:26487708 doi:http://dx.doi.org/10.1042/BSR20150183
- ↑ Morel F, Aninat C. The glutathione transferase kappa family. Drug Metab Rev. 2011 May;43(2):281-91. PMID:21428694 doi:10.3109/03602532.2011.556122
- ↑ Nazar-Stewart V, Motulsky AG, Eaton DL, White E, Hornung SK, Leng ZT, Stapleton P, Weiss NS. The glutathione S-transferase mu polymorphism as a marker for susceptibility to lung carcinoma. Cancer Res. 1993 May 15;53(10 Suppl):2313-8 PMID:8485718
- ↑ Kontur WS, Bingman CA, Olmsted CN, Wassarman DR, Ulbrich A, Gall DL, Smith RW, Yusko LM, Fox BG, Noguera DR, Coon JJ, Donohue TJ. Novosphingobium aromaticivorans uses a Nu-class glutathione-S-transferase as a glutathione lyase in breaking the beta-aryl ether bond of lignin. J Biol Chem. 2018 Feb 15. pii: RA117.001268. doi: 10.1074/jbc.RA117.001268. PMID:29449375 doi:http://dx.doi.org/10.1074/jbc.RA117.001268
- ↑ Henderson CJ, McLaren AW, Moffat GJ, Bacon EJ, Wolf CR. Pi-class glutathione S-transferase: regulation and function. Chem Biol Interact. 1998 Apr 24;111-112:69-82. PMID:9679544 doi:10.1016/s0009-2797(97)00176-2
- ↑ Pandey T, Chhetri G, Chinta R, Kumar B, Singh DB, Tripathi T, Singh AK. Functional classification and biochemical characterization of a novel rho class glutathione S-transferase in Synechocystis PCC 6803. FEBS Open Bio. 2014 Nov 24;5:1-7. PMID:25685659 doi:10.1016/j.fob.2014.11.006
- ↑ Sánchez Pérez LC, Zubillaga RA, García-Gutiérrez P, Landa A. Sigma-Class Glutathione Transferases (GSTσ): A New Target with Potential for Helminth Control. Trop Med Infect Dis. 2024 Apr 16;9(4):85. PMID:38668546 doi:10.3390/tropicalmed9040085
- ↑ Board PG. The omega-class glutathione transferases: structure, function, and genetics. Drug Metab Rev. 2011 May;43(2):226-35. PMID:21495794 doi:10.3109/03602532.2011.561353
- ↑ Board PG, Anders MW. Glutathione transferase zeta: discovery, polymorphic variants, catalysis, Drug Metab Rev. 2011 May;43(2):215-25. PMID:21303221 doi:10.3109/03602532.2010.549132
- ↑ Kilili KG, Atanassova N, Vardanyan A, Clatot N, Al-Sabarna K, Kanellopoulos PN, Makris AM, Kampranis SC. Differential roles of tau class glutathione S-transferases in oxidative stress. J Biol Chem. 2004 Jun 4;279(23):24540-51. PMID:15037622 doi:10.1074/jbc.M309882200
- ↑ Munyampundu JP, Xu YP, Cai XZ. Phi Class of Glutathione S-transferase Gene Superfamily Widely Exists in Nonplant Taxonomic Groups. Evol Bioinform Online. 2016 Feb 10;12:59-71. PMID:26884677 doi:10.4137/EBO.S35909
- ↑ Morgenstern R, Zhang J, Johansson K. Microsomal glutathione transferase 1: mechanism and functional roles. Drug Metab Rev. 2011 May;43(2):300-6. PMID:21495795 doi:10.3109/03602532.2011.558511
- ↑ Rossjohn J, Feil SC, Wilce MC, Sexton JL, Spithill TW, Parker MW. Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase. J Mol Biol. 1997 Nov 7;273(4):857-72. PMID:9367777 doi:10.1006/jmbi.1997.1338
