Glyoxalase

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<scene name='50/508460/Cv/5'>Human GLO1 active site contains Zn+2 atom</scene><ref>PMID:10521255</ref>. Water molecules are shown as red spheres.
<scene name='50/508460/Cv/5'>Human GLO1 active site contains Zn+2 atom</scene><ref>PMID:10521255</ref>. Water molecules are shown as red spheres.
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</StructureSection>
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==3D structures of glyoxalase==
==3D structures of glyoxalase==
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[[Glyoxalase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Glyoxalase 1 or lactoylglutathione lyase
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**[[1bh5]] – hGLO (mutant) – human<br />
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**[[1fro]] – hGLO + benzyl glutathione<br />
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**[[1qin]], [[1qip]] - hGLO + glutathione derivative<br />
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**[[3w0u]], [[3w0t]], [[3vw9]] – hGLO + inhibitor<br />
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**[[2za0]] – mGLO + methyl gerfelin – mouse<br />
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**[[4x2a]] – mGLO + baicalein<br />
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**[[4pv5]] – mGLO + glycyrrhetinic acid<br />
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**[[4opn]] – mGLO + MAH<br />
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**[[4kyk]], [[4kyh]] – mGLO + drug<br />
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**[[5d7z]] – maGLO – maize<br />
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**[[6bnn]], [[6bnx]], [[6bnz]] – maGLO (mutant)<br />
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**[[1fa8]] – EcGLO – ''Escherichia coli''<br />
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**[[1f9z]], [[1fa5]], [[1fa6]], [[1fa7]] – EcGLO + metal <br />
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**[[2c21]] – GLO – ''Leishmania major''<br />
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**[[3hdp]] – GLO + Ni – ''Clostridium acetobutylicum''<br />
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**[[4z04]] - GLO + glutathione – ''Brucella abortus''<br />
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*Glyoxalase 2
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**[[1qh3]] – hGLO + actate + cacodylate<br />
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**[[1qh5]] – hGLO + glutathione derivative<br />
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**[[1xm8]] – GLO – ''Arabidopsis thaliana''<br />
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**[[2p18]] - LiGLO – ''Leishmania infantum''<br />
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**[[2p1e]] – LiGLO + lactate
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*Glyoxalase 3
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**[[4lru]] – GLO – ''Candida albicans''<br />
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*Glyoxalase/bleomycin resistance protein/dioxygenase
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**[[2rbb]] – GLXI (mutant) – ''Burkholderia phytofirmans''<br />
 
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**[[4rt5]] – GLXI – ''Planctomyces limnophilus''<br />
 
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**[[4qb5]] – GLXI – ''Albidiferax ferrireducens''<br />
 
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**[[4n04]], [[4g6x]] – GLXI – ''Catenulispora acidiphia''<br />
 
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**[[4mym]] – GLXI – ''Nocardioides''<br />
 
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**[[4hc5]] – GLXI – ''Sphaerobacter thermophilus''<br />
 
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**[[4gym]] – GLXI – ''Conexibacter woesei''<br />
 
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**[[3vb0]] – GLXI – ''Sphingomonas wittichii''<br />
 
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**[[3rri]] – GLXI – ''Alicyclobacillus acidocaldarius''<br />
 
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**[[3kol]] – GLXI – ''Nostoc punctiforme''<br />
 
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**[[3b59]] – GLXI – ''Novosphingobium aromaticivorans''<br />
 
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**[[2rk9]] – GLXI (mutant) – ''Vibrio splendidus''<br />
 
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**[[2rk0]] – GLXI – ''Frankia''<br />
 
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**[[6cky]], [[5ump]], [[5umq]], [[5uhj]], [[5ujp]] – SuGLXI – ''Streptomyces uncialis''<br />
 
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**[[6bbx]], [[5w27]], [[5umy]] – SuGLXI + antibiotic<br />
 
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**[[5umw]], [[5umx]] – SuGLXI + riboflavin<br />
 
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**[[5drh]], [[5d4f]], [[5cb9]], [[5c6x]], [[5c68]], [[5c4p]] – TcGLXI – ''Thermomonospora curvata''<br />
 
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**[[5hcw]], [[5dfg]] – TcGLXI (mutant) <br />
 
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**[[5v0f]] – TcGLXI (mutant) + roxarsone <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion (grey) 1qin

Drag the structure with the mouse to rotate

References

  1. ↑ Dixon DP, Cummins L, Cole DJ, Edwards R. Glutathione-mediated detoxification systems in plants. Curr Opin Plant Biol. 1998 Jun;1(3):258-66. PMID:10066594
  2. ↑ Thornalley PJ. The glyoxalase system in health and disease. Mol Aspects Med. 1993;14(4):287-371. PMID:8277832
  3. ↑ Rabbani N, Thornalley PJ. Glyoxalase in diabetes, obesity and related disorders. Semin Cell Dev Biol. 2011 May;22(3):309-17. doi: 10.1016/j.semcdb.2011.02.015., Epub 2011 Feb 16. PMID:21335095 doi:http://dx.doi.org/10.1016/j.semcdb.2011.02.015
  4. ↑ Cameron AD, Ridderstrom M, Olin B, Kavarana MJ, Creighton DJ, Mannervik B. Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue. Biochemistry. 1999 Oct 12;38(41):13480-90. PMID:10521255

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