6s5h
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human RAB38 in complex with GTP== | |
| + | <StructureSection load='6s5h' size='340' side='right'caption='[[6s5h]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6s5h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S5H FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s5h OCA], [https://pdbe.org/6s5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s5h RCSB], [https://www.ebi.ac.uk/pdbsum/6s5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s5h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RAB38_HUMAN RAB38_HUMAN] May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).[UniProtKB:Q8QZZ8]<ref>PMID:21255211</ref> <ref>PMID:23084991</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | |
| - | + | *[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]] | |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Diaz-Saez L]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Huber K]] | ||
| + | [[Category: Jung S]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Structure of the human RAB38 in complex with GTP
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Diaz-Saez L | Edwards A | Huber K | Jung S | Von Delft F
