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6od9

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<StructureSection load='6od9' size='340' side='right'caption='[[6od9]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
<StructureSection load='6od9' size='340' side='right'caption='[[6od9]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6od9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OD9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OD9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6od9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusobacterium_ulcerans Fusobacterium ulcerans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OD9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.102&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5btp|5btp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6od9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6od9 OCA], [http://pdbe.org/6od9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6od9 RCSB], [http://www.ebi.ac.uk/pdbsum/6od9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6od9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6od9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6od9 OCA], [https://pdbe.org/6od9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6od9 RCSB], [https://www.ebi.ac.uk/pdbsum/6od9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6od9 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Riboswitches are conformationally dynamic RNAs that regulate gene expression by binding specific small molecules. ZTP riboswitches bind the purine-biosynthetic intermediate 5-aminoimidazole-4-carboxamide riboside 5'-monophosphate (ZMP) and its triphosphorylated form (ZTP). Ligand binding to this riboswitch ultimately upregulates genes involved in folate and purine metabolism. Using an X-ray free-electron laser (XFEL), the room-temperature structure of the Fusobacterium ulcerans ZTP riboswitch bound to ZMP has now been determined at 4.1 A resolution. This model, which was refined against a data set from approximately 750 diffraction images (each from a single crystal), was found to be consistent with that previously obtained from data collected at 100 K using conventional synchrotron X-radiation. These experiments demonstrate the feasibility of time-resolved XFEL experiments to understand how the ZTP riboswitch accommodates cognate ligand binding.
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Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser.,Jones C, Tran B, Conrad C, Stagno J, Trachman R 3rd, Fischer P, Meents A, Ferre-D'Amare A Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):496-500. doi:, 10.1107/S2053230X19008549. Epub 2019 Jun 28. PMID:31282869<ref>PMID:31282869</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6od9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Riboswitch 3D structures|Riboswitch 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fusobacterium ulcerans]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Amare, A R.Ferre-D]]
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[[Category: Ferre-D'Amare AR]]
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[[Category: Jones, C P]]
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[[Category: Jones CP]]
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[[Category: Tran, B]]
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[[Category: Tran B]]
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[[Category: Complex]]
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[[Category: Riboswitch]]
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[[Category: Rna]]
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[[Category: X-ray free-electron diffraction]]
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[[Category: Xfel]]
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[[Category: Zmp]]
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[[Category: Ztp]]
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Current revision

Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser

PDB ID 6od9

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