3op3

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Current revision (09:42, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3op3' size='340' side='right'caption='[[3op3]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
<StructureSection load='3op3' size='340' side='right'caption='[[3op3]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3op3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OP3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OP3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3op3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OP3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC25C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3op3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3op3 OCA], [https://pdbe.org/3op3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3op3 RCSB], [https://www.ebi.ac.uk/pdbsum/3op3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3op3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3op3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3op3 OCA], [http://pdbe.org/3op3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3op3 RCSB], [http://www.ebi.ac.uk/pdbsum/3op3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3op3 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MPIP3_HUMAN MPIP3_HUMAN]] Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.<ref>PMID:8119945</ref>
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[https://www.uniprot.org/uniprot/MPIP3_HUMAN MPIP3_HUMAN] Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.<ref>PMID:8119945</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Ball L]]
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[[Category: Ball, L]]
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[[Category: Barr A]]
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[[Category: Barr, A]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Edwards A]]
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[[Category: Delft, F von]]
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[[Category: Gileadi O]]
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[[Category: Edwards, A]]
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[[Category: Hatzos C]]
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[[Category: Gileadi, O]]
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[[Category: Joachimiak A]]
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[[Category: Hatzos, C]]
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[[Category: Johansson C]]
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[[Category: Joachimiak, A]]
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[[Category: Kim Y]]
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[[Category: Johansson, C]]
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[[Category: Knapp S]]
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[[Category: Kim, Y]]
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[[Category: Muniz J]]
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[[Category: Knapp, S]]
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[[Category: Savitsky P]]
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[[Category: Muniz, J]]
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[[Category: Vollmar M]]
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[[Category: Structural genomic]]
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[[Category: Weger A]]
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[[Category: Savitsky, P]]
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[[Category: Weigelt J]]
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[[Category: Vollmar, M]]
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[[Category: Von Delft F]]
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[[Category: Weger, A]]
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[[Category: Weigelt, J]]
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[[Category: Alpha-beta-alpha sandwich]]
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[[Category: Cytosol]]
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[[Category: Hydrolase]]
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[[Category: Kinase]]
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[[Category: Sgc]]
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Current revision

Crystal Structure of Cell Division Cycle 25C Protein Isoform A from Homo sapiens

PDB ID 3op3

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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