1ttw

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<StructureSection load='1ttw' size='340' side='right'caption='[[1ttw]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
<StructureSection load='1ttw' size='340' side='right'caption='[[1ttw]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ttw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis_co92 Yersinia pestis co92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TTW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ttw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_enterocolitica Yersinia enterocolitica] and [https://en.wikipedia.org/wiki/Yersinia_pestis_CO92 Yersinia pestis CO92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TTW FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ttw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttw OCA], [http://pdbe.org/1ttw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ttw RCSB], [http://www.ebi.ac.uk/pdbsum/1ttw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ttw ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ttw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttw OCA], [https://pdbe.org/1ttw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ttw RCSB], [https://www.ebi.ac.uk/pdbsum/1ttw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ttw ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q7BTX0_YERPE Q7BTX0_YERPE]
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Pathogenic Yersinia species use a type III secretion system to inject cytotoxic effector proteins directly into the cytosol of mammalian cells, where they neutralize the innate immune response by interfering with the signal-transduction pathways that control phagocytosis and inflammation. To be exported efficiently, some effectors must transiently associate with cognate cytoplasmic secretion chaperones. SycH is the chaperone for YopH, a potent eukaryotic-like protein tyrosine phosphatase that is essential for virulence. SycH also binds two negative regulators of type III secretion, YscM1 and YscM2, both of which share significant sequence homology with the chaperone-binding domain of YopH. Here, the structure of a complex between SycH and a stable fragment of YscM2 that was designed on the basis of limited proteolysis experiments is presented. The overall fold of SycH is very similar to the structures of other homodimeric secretion chaperones that have been determined to date. YscM2 wraps around SycH in an extended fashion, with some secondary but no tertiary structure, assuming a conformation distinct from the globular fold that it is predicted to adopt in the absence of SycH.
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Structure of the Yersinia pestis type III secretion chaperone SycH in complex with a stable fragment of YscM2.,Phan J, Tropea JE, Waugh DS Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1591-9. Epub 2004, Aug 26. PMID:15333930<ref>PMID:15333930</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1ttw" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Yersinia pestis co92]]
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[[Category: Yersinia enterocolitica]]
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[[Category: Phan, J]]
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[[Category: Yersinia pestis CO92]]
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[[Category: Tropea, J E]]
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[[Category: Phan J]]
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[[Category: Waugh, D S]]
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[[Category: Tropea JE]]
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[[Category: Chaperone]]
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[[Category: Waugh DS]]
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[[Category: Type iii secretion]]
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Current revision

Crystal structure of the Yersinia Pestis type III secretion chaperone SycH in complex with a stable fragment of YscM2

PDB ID 1ttw

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