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GTP-binding protein 3D structures

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(New page: == 3D Structures of GTP-binding protein == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *'''Small GTP-binding pr...)
Current revision (10:41, 23 April 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 4: Line 4:
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*'''Small GTP-binding protein'''
+
*GTP-binding protein
-
**[[2eki]] – hGBP TGS domain – NMR - human<br />
+
**[[2eki]] – hGBP TGS domain – NMR – human<br />
 +
**[[6k1z]] – hGBP1<br />
 +
**[[7e58]] – hGBP2<br />
**[[3r7w]], [[4arz]] – yGtr1 + Gtr2 – yeast<br />
**[[3r7w]], [[4arz]] – yGtr1 + Gtr2 – yeast<br />
 +
**[[1ni3]] – fyYchF – fission yeast<br />
**[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
**[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
**[[2qtf]] – SsHflx<br />
**[[2qtf]] – SsHflx<br />
Line 18: Line 21:
**[[1wxq]] – GBP – ''Pyrococcus horikoshii''<br />
**[[1wxq]] – GBP – ''Pyrococcus horikoshii''<br />
**[[1yr6]] - PaGBP – ''Pyrococcus abyssi''<br />
**[[1yr6]] - PaGBP – ''Pyrococcus abyssi''<br />
-
**[[1ni3]] – YchF – ''Schizosaccharomyces pombe''<br />
 
**[[5oxf]], [[5owv]] – GBP – ''Campylobacter jejuni''<br />
**[[5oxf]], [[5owv]] – GBP – ''Campylobacter jejuni''<br />
Line 32: Line 34:
**[[2b92]] - hGBP N terminal + GDP<br />
**[[2b92]] - hGBP N terminal + GDP<br />
**[[2bc9]] - hGBP N terminal + GPPNHP<br />
**[[2bc9]] - hGBP N terminal + GPPNHP<br />
-
**[[1yr7]], [[1yr8]] – PaGBP + GTP<br />
+
**[[2gao]] - hSar1A + GDP<br />
-
**[[1yr9]], [[1yra]], [[1yrb]], [[2oxr]] – PaGBP + GDP<br />
+
**[[8dzo]], [[8dzt]], [[8e0d]], [[8e0h]] - hSar1A (mutant) + G4P<br />
-
**[[3kxi]], [[2qth]] – SsHflx + GDP<br />
+
**[[8e0a]] - hSar1B + GDP<br />
 +
**[[6eg8]] – hGBP subunits α-1,β-1,γ-2 + GDP<br />
 +
**[[6au6]] – hGBP subunit α-1 + GDP<br />
 +
**[[6vkj]] – hGBP2 G domain + GDP<br />
 +
**[[7ckf]], [[7e5a]] – hGBP5 + GDP<br />
 +
**[[1git]], [[4aii]] - rRem2 G domain + GDP - rat<br />
 +
**[[2fa9]] – ChSar1B (mutant) + GDP – Chinese hamster<br />
 +
**[[2fmx]] - ChSar1B + GDP<br />
**[[1yzn]] – yPt1 + GPPNHP<br />
**[[1yzn]] – yPt1 + GPPNHP<br />
 +
**[[7kmt]] – yPt1 in TRAPPII complex – Cryo EM<br />
**[[1ky2]] – yPt7 + GPPNHP<br />
**[[1ky2]] – yPt7 + GPPNHP<br />
**[[1ky3]] – yPt7 + GDP<br />
**[[1ky3]] – yPt7 + GDP<br />
Line 42: Line 52:
**[[4phf]] – yPt7 (mutant) + GDP<br />
**[[4phf]] – yPt7 (mutant) + GDP<br />
**[[3rwm]], [[3rwo]] – yPt32 + GPPNHP<br />
**[[3rwm]], [[3rwo]] – yPt32 + GPPNHP<br />
 +
**[[7e8t]], [[7ea3]], [[7u05]], [[7u06]] - yPt32 in TRAPPII complex – Cryo EM<br />
**[[1ek0]] – yPt51 + GPPNHP<br />
**[[1ek0]] – yPt51 + GPPNHP<br />
-
**[[2hjg]], [[4dcs]], [[4dct]], [[4dcu]], [[4dcv]], [[4kyu]], [[5mbs]] – BsEngA + GDP<br />
+
**[[6x90]] – ySar1 + Sec12<br />
 +
**[[8bsh]] – ySar1 + Sec23 + Sec24 – Cryo EM<br />
 +
**[[6zga]] – ySar1 + Sec23 + Sec24 + peptide – Cryo EM<br />
 +
**[[2hjg]], [[4dcs]], [[4dct]], [[4dcu]], [[4dcv]], [[5x4b]], [[5mbs]] – BsEngA + GDP<br />
**[[5m7h]] – BsEngA + GMPPNP<br />
**[[5m7h]] – BsEngA + GMPPNP<br />
**[[5x4b]] – BsEngA N-terminal + GDP<br />
**[[5x4b]] – BsEngA N-terminal + GDP<br />
Line 52: Line 66:
**[[2dby]] – TtYchF + GDP<br />
**[[2dby]] – TtYchF + GDP<br />
**[[1wf3]] – Tt1341 + GNP<br />
**[[1wf3]] – Tt1341 + GNP<br />
-
**[[2gao]] - hSar1A + GDP<br />
 
-
**[[2fa9]] – ChSar1B (mutant) + GDP – Chinese hamster<br />
 
-
**[[2fmx]] - ChSar1B + GDP<br />
 
**[[5a9y]], [[4zcm]] – EcBipA + G-4-phosphate <br />
**[[5a9y]], [[4zcm]] – EcBipA + G-4-phosphate <br />
**[[5a9x]], [[5a9w]], [[4zcl]] – EcBipA + GDP <br />
**[[5a9x]], [[5a9w]], [[4zcl]] – EcBipA + GDP <br />
**[[5dn8]] – EngA + GDP – ''Coxiella burnetti''<br />
**[[5dn8]] – EngA + GDP – ''Coxiella burnetti''<br />
 +
**[[1yr7]], [[1yr8]] – PaGBP + GTP<br />
 +
**[[1yr9]], [[1yra]], [[1yrb]], [[2oxr]] – PaGBP + GDP<br />
 +
**[[3kxi]], [[2qth]] – SsHflx + GDP<br />
 +
**[[6xrs]] – GBP EngA + GDP – ''Neisseria gonorrhoeae''<br />
*GTP-binding protein complex with protein
*GTP-binding protein complex with protein
 +
**[[6cmo]], [[6qno]] – hGBP subunits α-1,β-1,γ-t1 + antibody + rhodopsin – Cryo EM<br />
 +
**[[6oij]], [[6oik]] – hGBP subunits α-1,β-1,γ-2 + antibody + AChR – Cryo EM<br />
 +
**[[6ot0]] – hGBP subunits α-1,β-1,γ-2 + antibody + smoothend homolog – Cryo EM<br />
 +
**[[6d9h]] – hGBP subunits α-1,β-1,γ-2 + AChR/adenosine receptor – Cryo EM<br />
 +
**[[6g79]] – hGBP subunits α-1,β-1,γ-2 + hydroxytryptamine receptor – Cryo EM<br />
 +
**[[6li3]] – hGBP subunits α-1,β-1,γ-2 + nanobody + G protein coupled receptor – Cryo EM<br />
 +
**[[6e3y]] – hGBP subunits α-1,β-1,γ-2 + nanobody + calcitonin receptor + receptor activity-modifying protein – Cryo EM<br />
 +
**[[6pb0]], [[6pb1]] – hGBP subunits α-1,β-1,γ-2 + nanobody + corticotropin-releasing factor receptor + urocortin – Cryo EM<br />
 +
**[[7joz]] – hGBP subunits α-1,β-1,γ-2 + nanobody + dopamine receptor + agonist – Cryo EM<br />
 +
**[[6wi9]], [[6wzg]] – hGBP subunits α-1,β-1,γ-2 + nanobody + secretin receptor + secretin – Cryo EM<br />
 +
**[[6lmk]], [[6lml]], [[6wpw]] – hGBP subunits α-1,β-1,γ-2 + nanobody + glucagon receptor + glucagon – Cryo EM<br />
 +
**[[6b3j]] – hGBP subunits α-1,β-1,γ-2 + nanobody + glucagon-like peptide receptor + exendin – Cryo EM<br />
 +
**[[6osa]] – hGBP subunits α-1,β-1,γ-2 + JMV449 + neurotensin receptor – Cryo EM<br />
 +
**[[6os9]] – hGBP subunits α-1,β-1,γ-2 + JMV449 + scFv + neurotensin receptor – Cryo EM<br />
 +
**[[7dfl]] – hGBP subunits α-1,β-1,γ-2 + scFv + histamine receptor + histamine – Cryo EM<br />
 +
**[[6kpf]], [[6kpg]] – hGBP subunits α-1,β-1,γ-2 + scFv + cannabinoid receptor – Cryo EM<br />
 +
**[[6lfm]], [[6lfo]] – hGBP subunits α-1,β-1,γ-2 + scFv + interleukin-8 + C-X-C chemokine receptor – Cryo EM<br />
 +
**[[6loj]] – hGBP1 + invasion plasmid antigen + GDP<br />
 +
**[[6m8s]] – bGBP subunits b-1, g-2 + KCTD12<br />
 +
**[[6dde]], [[6ddf]] – bGBP subunits α-1,β-1,γ-2 + scFv + opioid receptor + DAMGO – Cryo EM<br />
 +
**[[6b20]] – bGBP subunits β-1,γ-t1 (mutant) + nanobody – bovine<br />
 +
**[[6r3q]], [[6r4o]], [[6r4p]] – bGBP subunit α-1 + adenylae cyclase – Cryo EM<br />
 +
**[[7jjo]] – bGBP subunits α-1,β-1,γ-2 + nanobody + b1 adrenergic receptor – Cryo EM<br />
 +
**[[6mhe]] – rGBP subunit α-1 + peptide + GDP<br />
 +
**[[6mhf]] – rGBP subunit α-1 + girdin + GDP<br />
 +
**[[6tyl]], [[6ukt]] – rGBP subunit α-1 + nanobody + RIC8A <br />
 +
**[[6n9g]] – mGBP subunit β-5 + RGS7 - mouse<br />
**[[3cue]] – yPt1 + transport protein subunits<br />
**[[3cue]] – yPt1 + transport protein subunits<br />
**[[2bcg]], [[1ukv]] - yPt1 + secretory pathway GDP-dissociation inhibitor<br />
**[[2bcg]], [[1ukv]] - yPt1 + secretory pathway GDP-dissociation inhibitor<br />
**[[3cpj]] – yPt31 + Rab GDP-dissociation inhibitor<br />
**[[3cpj]] – yPt31 + Rab GDP-dissociation inhibitor<br />
**[[1m2o]] – ySar1 + protein transport protein sec23<br />
**[[1m2o]] – ySar1 + protein transport protein sec23<br />
 +
**[[2qtv]] - ySar1 + protein transport protein sec23 + GNP<br />
**[[6gni]] - ySar1 + protein transport protein sec23 + Sec24 + GNP<br />
**[[6gni]] - ySar1 + protein transport protein sec23 + Sec24 + GNP<br />
 +
**[[6jwp]] – yGtr1 + Gtr2 + Meh1 + Ego2 + Slm4 + GNP<br />
**[[3syn]] – BsFlhf + ATP-binding protein<br />
**[[3syn]] – BsFlhf + ATP-binding protein<br />
Line 71: Line 115:
**[[4idn]] – hGDP3 cytoplasmic domain + GNP<br />
**[[4idn]] – hGDP3 cytoplasmic domain + GNP<br />
-
**[[4ido]], [[4idq]], [[3q5d]], [[3q5e]], [[3qnu]], [[3qof]] – hGDP3 cytoplasmic domain + GDP<br />
+
**[[4ido]], [[4idq]], [[3q5d]], [[3q5e]], [[3qnu]], [[3qof]], [[6b9g]], [[6xjn]], [[7ol3]] – hGDP3 cytoplasmic domain + GDP<br />
**[[6b9f]], [[6b9e]], [[6b9d]] – hGDP3 cytoplasmic domain (mutant) + GDP<br />
**[[6b9f]], [[6b9e]], [[6b9d]] – hGDP3 cytoplasmic domain (mutant) + GDP<br />
* GTP-binding protein LepA
* GTP-binding protein LepA
-
**[[3cb4]] – EcLepA <br />
 
**[[2ywe]] – AaLepA – ''Aquifex aeolicus''<br />
**[[2ywe]] – AaLepA – ''Aquifex aeolicus''<br />
-
**[[4k8w]] – LepA – ''Streptococcus pyogenes''<br />
 
**[[2ywf]] – AaLepA + GMP-PNP<br />
**[[2ywf]] – AaLepA + GMP-PNP<br />
**[[2ywg]] - AaLepA + GTP<br />
**[[2ywg]] - AaLepA + GTP<br />
**[[2ywh]] - AaLepA + GDP<br />
**[[2ywh]] - AaLepA + GDP<br />
 +
**[[3cb4]] – EcLepA <br />
**[[3deg]] – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM<br />
**[[3deg]] – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM<br />
-
 
+
**[[4k8w]] – LepA – ''Streptococcus pyogenes''<br />
*G protein bound to a G protein-coupled receptor
*G protein bound to a G protein-coupled receptor
Line 105: Line 148:
**[[1yu9]] - hRab-4A + GPPNHP<br />
**[[1yu9]] - hRab-4A + GPPNHP<br />
**[[1yzq]] - hRab-6 + GNP<br />
**[[1yzq]] - hRab-6 + GNP<br />
 +
**[[6hh2]] – hRab-7L1 + GDP<br />
**[[1x3s]] – hRab-18 + GPPNHP
**[[1x3s]] – hRab-18 + GPPNHP
**[[6huf]] - hRab-27A + GNP<br />
**[[6huf]] - hRab-27A + GNP<br />
 +
**[[7opp]], [[7opq]], [[7opr]] - hRab-27A/SLP2A + GNP<br />
 +
**[[6ff8]] - hRab-32 + GTP<br />
 +
**[[6hdu]], [[6s5h]] - hRab-38 + GTP<br />
 +
**[[6s6a]], [[6s6d]] - hRagA (mutant) + RagC (mutant) + GDP + GTP<br />
**[[2atx]] – hTc10 + GPPNHP<br />
**[[2atx]] – hTc10 + GPPNHP<br />
**[[1g16]] – ySec4 + GDP<br />
**[[1g16]] – ySec4 + GDP<br />
**[[1g17]] - ySec4 + GIP<br />
**[[1g17]] - ySec4 + GIP<br />
 +
**[[6o62]] – Sec4 + GDP – ''Candida albicans''<br />
*Ras-related small GTP-binding protein complex with protein
*Ras-related small GTP-binding protein complex with protein
Line 119: Line 168:
**[[6ba6]] – hRab-1B + talin-1<br />
**[[6ba6]] – hRab-1B + talin-1<br />
**[[4m8n]] – hRab-1B + plexin<br />
**[[4m8n]] – hRab-1B + plexin<br />
 +
**[[6kyk]], [[7c7i]] – hRab-1B + Shank3<br />
 +
**[[7c7j]] – hRab-1B (mutant) + Shank3<br />
 +
**[[6uzk]] – hRab-1B + KRIT1 + GNP<br />
**[[4dxa]] – hRab-1B (mutant) + KRIT1<br />
**[[4dxa]] – hRab-1B (mutant) + KRIT1<br />
**[[4hdq]], [[4hdo]] – hRab-1B + HEG1 + KRIT1<br />
**[[4hdq]], [[4hdo]] – hRab-1B + HEG1 + KRIT1<br />
Line 124: Line 176:
**[[5kho]] – hRab-1B + Ras-interacting protein 1<br />
**[[5kho]] – hRab-1B + Ras-interacting protein 1<br />
**[[4mh0]], [[4mgz]], [[4mgy]], [[4mgk]], [[4mgi]] - hRap-1B + Rap guanine nucleotide exchange factor 4<br />
**[[4mh0]], [[4mgz]], [[4mgy]], [[4mgk]], [[4mgi]] - hRap-1B + Rap guanine nucleotide exchange factor 4<br />
 +
**[[6sku]] – hRab-1B + phosphocholine transferase + GDP<br />
 +
**[[6sq2]] – hRab-8A + RILPL2 + GTP<br />
**[[1z0k]] – hRab-4 + rabenosyn-5<br />
**[[1z0k]] – hRab-4 + rabenosyn-5<br />
**[[3tw8]] – hRab-1C + DENND<br />
**[[3tw8]] – hRab-1C + DENND<br />
**[[4ojk]] – hRab-11B + cGMP-dependent protein kinase 2<br />
**[[4ojk]] – hRab-11B + cGMP-dependent protein kinase 2<br />
 +
**[[6zay]] – hRab-33B + autophagy-related protein + GDP<br />
**[[6ekk]] – hRab-35 + connecdenn + GDP<br />
**[[6ekk]] – hRab-35 + connecdenn + GDP<br />
**[[6if2]] – hRab-35 (mutant) + iporin + GTP<br />
**[[6if2]] – hRab-35 (mutant) + iporin + GTP<br />
Line 132: Line 187:
**[[6ces]] – hRag-C (mutant) + NPRL2 + NPRL3 + DEPDC5 + GNP – Cryo EM<br />
**[[6ces]] – hRag-C (mutant) + NPRL2 + NPRL3 + DEPDC5 + GNP – Cryo EM<br />
**[[6ehr]], [[5x6v]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5<br />
**[[6ehr]], [[5x6v]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5<br />
 +
**[[6u62]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + GTP + GDP – Cryo EM<br />
 +
**[[7uxc]] – hRag-A + hRag-C in MtorC1-TFEB-RAG-ragulator complex + GTP + GDP – Cryo EM<br />
 +
**[[8dhb]] – hRag-A + hRag-C in FLCN-Gap complex – Cryo EM<br />
 +
**[[6wj2]], [[6wj3]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + GDP – Cryo EM<br />
 +
**[[6nzd]], [[6ulg]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + folliculin + folliculin-interacting protein + GDP – Cryo EM<br />
 +
**[[6sb2]] – hRag-A + hRag-C + Mtor + Torc + Raptor + GDP + GTP – Cryo EM<br />
 +
**[[7t3a]], [[7t3b]], [[7t3c]] – hRag-A + hRag-C in GATOR1-RAG-Ragulator complex – Cryo EM<br />
 +
**[[7ux2]] – hRag-A + hRag-C in RAPTOR-TFEB1-RAG-Ragulator complex – Cryo EM<br />
 +
**[[7uxh]] – hRag-A + hRag-C in TORC1-TFEB1-RAG-Ragulator complex – Cryo EM<br />
 +
**[[6sb0]] – hRag-A + hRag-C + Mtor + Torc + Raptor + Pro-rich Akt1 substrate + GDP + GTP – Cryo EM<br />
 +
**[[6oq3]], [[6oq4]] – hRap-1B + krev interacting trapped protein + GNP<br />
 +
**[[6sur]], [[6y09]] – mRab-33B (mutant) + autophagy-related protein + GTP<br />
*'''Interferon-induced GTP-binding protein'''
*'''Interferon-induced GTP-binding protein'''
Line 144: Line 211:
**[[4x0r]] – hMx2 stalk region (mutant)<br />
**[[4x0r]] – hMx2 stalk region (mutant)<br />
**[[4whj]] – hMx2 residues 84-715 (mutant)<br />
**[[4whj]] – hMx2 residues 84-715 (mutant)<br />
 +
**[[5uot]] – hMxB – Cryo EM<br />
*'''Rho-related small GTP-binding protein'''
*'''Rho-related small GTP-binding protein'''
Line 151: Line 219:
*Rho-related small GTP-binding protein complex with nucleotide
*Rho-related small GTP-binding protein complex with nucleotide
 +
**[[6d71]] – hRho1 + GTP<br />
**[[2cls]] – hRho6 + GTP<br />
**[[2cls]] – hRho6 + GTP<br />
**[[2fv8]] - hRhoB + GDP<br />
**[[2fv8]] - hRhoB + GDP<br />
 +
**[[6hxu]] - hRhoB (mutant) + GTP<br />
**[[2gcn]] – hRhoC + GDP<br />
**[[2gcn]] – hRhoC + GDP<br />
**[[2gco]] – hRhoC + GPPNHP<br />
**[[2gco]] – hRhoC + GPPNHP<br />
Line 159: Line 229:
**[[1m7b]] - hRhoE + GTP<br />
**[[1m7b]] - hRhoE + GTP<br />
**[[1gwn]] - mRhoE + GTP <br />
**[[1gwn]] - mRhoE + GTP <br />
-
**[[1a4r]] - hCdc42 (mutant) + GDP<br />
+
**[[8etd]] – fyRho1 + GDP <br />
-
**[[1an0]] - hCdc42 + GDP<br />
+
-
**[[2qrz]] - hCdc42 + GCP<br />
+
*Rho-related small GTP-binding protein complex with protein
*Rho-related small GTP-binding protein complex with protein
**[[2v55]] – hRhoE + Rho-associated protein kinase<br />
**[[2v55]] – hRhoE + Rho-associated protein kinase<br />
 +
**[[8b2k]] – hRhoE + 14-3-3 protein<br />
**[[3q3j]] – hRho6 + plexin-A2 nucleotide-binding domain<br />
**[[3q3j]] – hRho6 + plexin-A2 nucleotide-binding domain<br />
**[[2rex]] – hRho6 + plexin-B1<br />
**[[2rex]] – hRho6 + plexin-B1<br />
 +
**[[7kdc]] - hRhoD + plexin-B2 + GNP<br />
**[[1cc0]] – hRhoA + GDP-dissociation inhibitor + GDP<br />
**[[1cc0]] – hRhoA + GDP-dissociation inhibitor + GDP<br />
**[[6bca]] - hRhoA + kinase anchor protein + GTP<br />
**[[6bca]] - hRhoA + kinase anchor protein + GTP<br />
 +
**[[6sge]] - hRhoB + nanobody + GTP<br />
 +
**[[6uka]] - hRhoG + ELMO + GNP<br />
 +
**[[7y4a]] - hRhoG + ELMO + GDP<br />
**[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3 + cancidas<br />
**[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3 + cancidas<br />
 +
 +
*G25K GTP-binding protein or cell division control protein 42 homolog
 +
 +
**[[1a4r]] - hCdc42 (mutant) + GDP<br />
 +
**[[1an0]] - hCdc42 + GDP<br />
 +
**[[2qrz]] - hCdc42 + GCP<br />
**[[1gzs]] – Cdc42 + guanine nucleotide exchange factor – ''Salmonella typhimurium''<br />
**[[1gzs]] – Cdc42 + guanine nucleotide exchange factor – ''Salmonella typhimurium''<br />
**[[2kb0]] - hCdc42 (mutant)<br />
**[[2kb0]] - hCdc42 (mutant)<br />
Line 179: Line 258:
**[[3eg5]] - hCdc42 + protein diaphanous homolog 1 + GMPPNP<br />
**[[3eg5]] - hCdc42 + protein diaphanous homolog 1 + GMPPNP<br />
**[[3gcg]] - hCdc42 + MAP<br />
**[[3gcg]] - hCdc42 + MAP<br />
-
**[[4ltr]] - hCdc42 + AMP-protein transferase<br />
 
**[[1nf3]] - hCdc42 + Par6<br />
**[[1nf3]] - hCdc42 + Par6<br />
**[[2ase]] - hCdc42 (mutant) - NMR<br />
**[[2ase]] - hCdc42 (mutant) - NMR<br />
**[[1ki1]] – hCdc42 + intersectin long form<br />
**[[1ki1]] – hCdc42 + intersectin long form<br />
 +
**[[5hzk]] - hCdc42 (mutant) + intersectin<br />
**[[1ees]] – hCdc42 + MapK3 peptide - NMR<br />
**[[1ees]] – hCdc42 + MapK3 peptide - NMR<br />
**[[1doa]] - hCdc42 + GDP-dissociation inhibitor<br />
**[[1doa]] - hCdc42 + GDP-dissociation inhibitor<br />
 +
**[[6tky]], [[6tkz]] - hCdc42 + dedicator of cytokinesis protein<br />
**[[2ngr]] – hCdc42 + GTPase-activating protein C terminal + GDP<br />
**[[2ngr]] – hCdc42 + GTPase-activating protein C terminal + GDP<br />
**[[1am4]] – hCdc42 + GTPase-activating protein rhoGAP + GNP<br />
**[[1am4]] – hCdc42 + GTPase-activating protein rhoGAP + GNP<br />
Line 195: Line 275:
**[[1cf4]] – hCdc42 (mutant) + dedicator of cytokinesis protein 8<br />
**[[1cf4]] – hCdc42 (mutant) + dedicator of cytokinesis protein 8<br />
**[[4itr]] – hCdc42 + AMP-protein transferase + GDP + AMP<br />
**[[4itr]] – hCdc42 + AMP-protein transferase + GDP + AMP<br />
 +
**[[6aj4]], [[6ajl]] - hCdc42 (mutant) + dedicator of cytokinesis protein<br />
 +
**[[5upl]], [[5upk]] - hCdc42 + PAK 4<br />
 +
**[[5fi1]] - hCdc42 + PTDINS dependent RAC exchanger<br />
 +
**[[6siu]] - hCdc42 + IBPA + GDP<br />
*'''Rac-like GTP-binding protein'''
*'''Rac-like GTP-binding protein'''
Line 222: Line 306:
**[[3ieu]] – EcERA + GDP <br />
**[[3ieu]] – EcERA + GDP <br />
**[[3iev]] – AaERA + RNA + Mg-GNP <br />
**[[3iev]] – AaERA + RNA + Mg-GNP <br />
 +
**[[7c1o]] – AaERA + GDP <br />
**[[1x1l]] – TtERA + RNA – Cryo EM<br />
**[[1x1l]] – TtERA + RNA – Cryo EM<br />
**[[1x18]] – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM<br />
**[[1x18]] – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM<br />
Line 233: Line 318:
**[[6bt0]], [[6bsx]] - hRheb + GDP + inhibitor<br />
**[[6bt0]], [[6bsx]] - hRheb + GDP + inhibitor<br />
**[[3t5g]] – hRheb + GMP-PDE delta<br />
**[[3t5g]] – hRheb + GMP-PDE delta<br />
 +
**[[6bcu]] – hRheb + mTORC1 – Cryo EM<br />
**[[4o25]] – mRheb + GTP - mouse<br />
**[[4o25]] – mRheb + GTP - mouse<br />
**[[4o2l]] - mRheb (mutant) + GTP <br />
**[[4o2l]] - mRheb (mutant) + GTP <br />
Line 276: Line 362:
**[[3gjx]] – hRan + snurportin 1 + exportin 1 + GTP <br />
**[[3gjx]] – hRan + snurportin 1 + exportin 1 + GTP <br />
**[[3nby]], [[3nbz]], [[3nc0]] – hRan (mutant) + snurportin 1 + exportin 1 + GTP <br />
**[[3nby]], [[3nbz]], [[3nc0]] – hRan (mutant) + snurportin 1 + exportin 1 + GTP <br />
 +
**[[6tvo]] – hRan (mutant) + exportin 1 + leptomycin + GTP <br />
 +
**[[6x2p]], [[6x2s]] – hRan (mutant) + exportin 1 + Mkk1 + GNP <br />
**[[1k5d]], [[5zpu]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GTP analog<br />
**[[1k5d]], [[5zpu]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GTP analog<br />
**[[1k5g]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GDP <br />
**[[1k5g]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GDP <br />
Line 282: Line 370:
**[[5jlj]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + inhibitor<br />
**[[5jlj]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + inhibitor<br />
**[[4wvf]] – hRan + Ran-specific GTPase-activating protein + CRM1P + GNP + inhibitor<br />
**[[4wvf]] – hRan + Ran-specific GTPase-activating protein + CRM1P + GNP + inhibitor<br />
-
**[[6cit]] – hRan + Ran-specific GTPase-activating protein + exportin + NS2<br />
+
**[[6cit]], [[6kft]] – hRan + Ran-specific GTPase-activating protein + exportin + NS2 + GNP<br />
 +
**[[6x2r]] – hRan + Ran-specific GTPase-activating protein + exportin + Eif4E + GNP<br />
 +
**[[6x2u]], [[6x2v]], [[6x2w]] – hRan + Ran-specific GTPase-activating protein + exportin + Pki-alpha peptide + GNP<br />
 +
**[[6x2x]] – hRan + Ran-specific GTPase-activating protein + exportin + Mkk1 peptide + GNP<br />
 +
**[[6x2y]] – hRan + Ran-specific GTPase-activating protein + exportin + diaphanous homolog peptide + GNP<br />
**[[6a3e]], [[6a3c]], [[6a3b]], [[6a3a]], [[6a38]] – hRan + Ran-specific GTPase-activating protein + exportin + NES + GTP<br />
**[[6a3e]], [[6a3c]], [[6a3b]], [[6a3a]], [[6a38]] – hRan + Ran-specific GTPase-activating protein + exportin + NES + GTP<br />
**[[5ytb]], [[5yst]], [[5yro]] – hRan (mutant) + Ran-specific GTPase-activating protein + exportin + GTP<br />
**[[5ytb]], [[5yst]], [[5yro]] – hRan (mutant) + Ran-specific GTPase-activating protein + exportin + GTP<br />
Line 292: Line 384:
**[[5dis]] – hRan (mutant) + exportin 1 + RNA U transporter + Nup214 + GTP <br />
**[[5dis]] – hRan (mutant) + exportin 1 + RNA U transporter + Nup214 + GTP <br />
**[[3a6p]] – dRan + pre-microRNA + exportin 5 + peptide <br />
**[[3a6p]] – dRan + pre-microRNA + exportin 5 + peptide <br />
 +
**[[5yu6]] – dRan + exportin 5 + peptide + GTP<br />
**[[3icq]] – yRan + RNA + exportin T <br />
**[[3icq]] – yRan + RNA + exportin T <br />
**[[3m1i]] – yRan + Ran-specific GTPase-activating protein + exportin 1 + GTP <br />
**[[3m1i]] – yRan + Ran-specific GTPase-activating protein + exportin 1 + GTP <br />
 +
 +
*Small GTP-binding protein
 +
 +
**[[5kh0]] - GBP – ''Thermosipho melanesiensis''<br />
 +
 +
*Small GTP-binding protein ERA
 +
 +
**[[1ega]] – EcERA <br />
 +
**[[3ieu]] – EcERA + GDP <br />
 +
**[[3iev]] – AaERA + RNA + Mg-GNP <br />
 +
**[[1x1l]] – TtERA + RNA – Cryo EM<br />
 +
**[[1x18]] – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM<br />
 +
 +
*Small GTP-binding protein Gem
 +
 +
**[[2cjw]], [[2ht6]], [[2g3y]] – hGem G domain + GDP<br />
 +
 +
*Small GTP-binding protein Rheb
 +
 +
**[[1xtq]], [[5yxh]] – hRheb + GDP<br />
 +
**[[7bta]], [[7btc]] - hRheb (mutant) + GDP <br />
 +
**[[1xts]] - hRheb + GTP<br />
 +
**[[1xtr]] - hRheb + GPPNHP<br />
 +
**[[7btd]] - hRheb (mutant) + GPPNHP <br />
 +
**[[3sea]] - hRheb + GDP + GNP<br />
 +
**[[6bt0]], [[6bsx]] - hRheb + GDP + inhibitor<br />
 +
**[[3t5g]] – hRheb + GMP-PDE delta<br />
 +
**[[4o25]] – mRheb + GTP - mouse<br />
 +
**[[4o2l]] - mRheb (mutant) + GTP <br />
 +
**[[4o2r]] - mRheb (mutant) + GDP <br />
 +
**[[2l0x]] – rRheb + GDP<br />
 +
 +
*Nucleolar GTP-binding protein 1
 +
 +
**[[7o9k]], [[7o9m]], [[7odt]], [[7of2]], [[7of4]], [[7of6]], [[7of7]], [[7oi6]], [[7pd3]] – hNGBP 1 in 39S mitoribosome – Cryo EM<br />
 +
**[[6lss]], [[6lu8]] – hNGBP 1 in 60S ribosome – Cryo EM<br />
 +
**[[3jct]], [[4v7f]], [[5jcs]], [[6c0f]], [[6elz]], [[6em1]], [[6em5]], [[6m62]], [[6n8l]], [[6ylg]], [[6ylh]], [[6ylx]], [[6yly]], [[7bt6]], [[7btb]], [[7nac]], [[7naf]], [[7of1]], [[7oh3]], [[7ohp]], [[7ohq]], [[7ohr]], [[7ohs]], [[7oht]], [[7ohv]], [[7ohw]], [[7ohx]], [[7ohy]], [[7r7a]], [[7r7c]], [[7u0h]], [[7ug6]], [[7uoo]], [[7uqb]], [[7uqz]], [[7uui]], [[7z34]], [[8hfr]] – yNGBP 1 in pre-60S ribosome – Cryo EM<br />
 +
**[[7nrc]] – yNGBP 1 in 80S ribosome – Cryo EM<br />
 +
**[[8esq]], [[8etc]], [[8etg]], [[8eth]], [[8eti]], [[8etj]], [[8eup]], [[8euy]], [[8ev3]] – fyNGBP 1 in 60S ribosome – Cryo EM<br />
 +
**[[4csu]], [[5ady]], [[5zzm]], [[7bl2]], [[7bl3]], [[7bl4]], [[7bl5]], [[7bl6]], [[7yla]] – EcNGBP 1 in pre-50S ribosome – Cryo EM<br />
 +
**[[5aa0]] – TtNGBP 1 in 50S ribosome – Cryo EM<br />
 +
**[[6yxx]] – NGBP 1 in 12S mitoribosome – Trypanosoma brucei - Cryo EM<br />
 +
**[[8a57]] – NGBP in 50S ribosome – Listeria monocytogenes - Cryo EM<br />
*'''Small GTPase h-Ras''' see [[GTPase HRas]]
*'''Small GTPase h-Ras''' see [[GTPase HRas]]

Current revision

3D Structures of GTP-binding protein

Updated on 23-April-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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