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| | <StructureSection load='2aw6' size='340' side='right'caption='[[2aw6]], [[Resolution|resolution]] 3.00Å' scene=''> | | <StructureSection load='2aw6' size='340' side='right'caption='[[2aw6]], [[Resolution|resolution]] 3.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2aw6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AW6 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2aw6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AW6 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2awi|2awi]], [[2axu|2axu]], [[2axv|2axv]], [[2axz|2axz]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aw6 OCA], [http://pdbe.org/2aw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aw6 RCSB], [http://www.ebi.ac.uk/pdbsum/2aw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2aw6 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aw6 OCA], [https://pdbe.org/2aw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aw6 RCSB], [https://www.ebi.ac.uk/pdbsum/2aw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aw6 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q04114_ENTFL Q04114_ENTFL] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]] | + | [[Category: Enterococcus faecalis]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Brown, C K]] | + | [[Category: Brown CK]] |
| - | [[Category: Dunny, G M]] | + | [[Category: Dunny GM]] |
| - | [[Category: Earhart, C A]] | + | [[Category: Earhart CA]] |
| - | [[Category: Gu, Z Y]] | + | [[Category: Gu ZY]] |
| - | [[Category: Kozlowicz, B K]] | + | [[Category: Kozlowicz BK]] |
| - | [[Category: Ohlendorf, D H]] | + | [[Category: Ohlendorf DH]] |
| - | [[Category: Shi, K]] | + | [[Category: Shi K]] |
| - | [[Category: Dna binding]]
| + | |
| - | [[Category: Pheromone]]
| + | |
| - | [[Category: Regulatory]]
| + | |
| - | [[Category: Repressor]]
| + | |
| - | [[Category: Transcription]]
| + | |
| Structural highlights
Function
Q04114_ENTFL
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Many bacterial activities, including expression of virulence factors, horizontal genetic transfer, and production of antibiotics, are controlled by intercellular signaling using small molecules. To date, understanding of the molecular mechanisms of peptide-mediated cell-cell signaling has been limited by a dearth of published information about the molecular structures of the signaling components. Here, we present the molecular structure of PrgX, a DNA- and peptide-binding protein that regulates expression of the conjugative transfer genes of the Enterococcus faecalis plasmid pCF10 in response to an intercellular peptide pheromone signal. Comparison of the structures of PrgX and the PrgX/pheromone complex suggests that pheromone binding destabilizes PrgX tetramers, opening a 70-bp pCF10 DNA loop required for conjugation repression.
Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis.,Shi K, Brown CK, Gu ZY, Kozlowicz BK, Dunny GM, Ohlendorf DH, Earhart CA Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18596-601. Epub 2005 Dec 8. PMID:16339309[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Shi K, Brown CK, Gu ZY, Kozlowicz BK, Dunny GM, Ohlendorf DH, Earhart CA. Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18596-601. Epub 2005 Dec 8. PMID:16339309
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