We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
2z5i
From Proteopedia
(Difference between revisions)
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_2z5i", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...) |
|||
| (11 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2z5i.jpg|left|200px]] | ||
| - | + | ==Crystal structure of the head-to-tail junction of tropomyosin== | |
| - | + | <StructureSection load='2z5i' size='340' side='right'caption='[[2z5i]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | or the | + | <table><tr><td colspan='2'>[[2z5i]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5I FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5i OCA], [https://pdbe.org/2z5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5i RCSB], [https://www.ebi.ac.uk/pdbsum/2z5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5i ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.[https://www.uniprot.org/uniprot/TPM1_RABIT TPM1_RABIT] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5i_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z5i ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Gcn4 3D Structures|Gcn4 3D Structures]] | |
| - | + | *[[Gnc4 3D Structures|Gnc4 3D Structures]] | |
| - | == | + | *[[Tropomyosin 3D structures|Tropomyosin 3D structures]] |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Saccharomyces cerevisiae | + | [[Category: Oryctolagus cuniculus]] |
| - | [[Category: Igarashi | + | [[Category: Saccharomyces cerevisiae]] |
| - | [[Category: Kudou | + | [[Category: Igarashi N]] |
| - | [[Category: Murakami | + | [[Category: Kudou N]] |
| - | [[Category: Nozawa | + | [[Category: Murakami K]] |
| - | [[Category: Shirakihara | + | [[Category: Nozawa K]] |
| - | [[Category: Stewart | + | [[Category: Shirakihara Y]] |
| - | [[Category: Tomii | + | [[Category: Stewart M]] |
| - | [[Category: Wakabayashi | + | [[Category: Tomii K]] |
| - | [[Category: Wakatsuki | + | [[Category: Wakabayashi T]] |
| - | [[Category: Yasunaga | + | [[Category: Wakatsuki S]] |
| - | + | [[Category: Yasunaga T]] | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of the head-to-tail junction of tropomyosin
| |||||||||||
