2dc7

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<StructureSection load='2dc7' size='340' side='right'caption='[[2dc7]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
<StructureSection load='2dc7' size='340' side='right'caption='[[2dc7]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2dc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DC7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2dc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DC7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=042:N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-THREONYL-L-ISOLEUCINE'>042</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ito|1ito]], [[1qdq|1qdq]], [[2dc6|2dc6]], [[2dc8|2dc8]], [[2dc9|2dc9]], [[2dca|2dca]], [[2dcb|2dcb]], [[2dcc|2dcc]], [[2dcd|2dcd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=042:N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-THREONYL-L-ISOLEUCINE'>042</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_B Cathepsin B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.1 3.4.22.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dc7 OCA], [https://pdbe.org/2dc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dc7 RCSB], [https://www.ebi.ac.uk/pdbsum/2dc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dc7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dc7 OCA], [http://pdbe.org/2dc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dc7 RCSB], [http://www.ebi.ac.uk/pdbsum/2dc7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dc7 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATB_BOVIN CATB_BOVIN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bovin]]
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[[Category: Bos taurus]]
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[[Category: Cathepsin B]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Watanabe, D]]
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[[Category: Watanabe D]]
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[[Category: Ca042]]
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[[Category: Cathepsin b]]
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[[Category: Cysteine protease]]
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[[Category: Ec 3 4.22 1]]
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[[Category: Hydrolase]]
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X-ray crystal structure analysis of bovine spleen cathepsin B-CA042 complex

PDB ID 2dc7

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