6kj1
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6kj1 is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==200kV MicroED structure of FUS (37-42) SYSGYS solved from merged datasets at 0.65 A== |
| - | + | <StructureSection load='6kj1' size='340' side='right'caption='[[6kj1]], [[Resolution|resolution]] 0.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6kj1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KJ1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution|Resolution]] 0.65Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kj1 OCA], [https://pdbe.org/6kj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kj1 RCSB], [https://www.ebi.ac.uk/pdbsum/6kj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kj1 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN] Frontotemporal dementia with motor neuron disease;Hereditary essential tremor;Amyotrophic lateral sclerosis;Juvenile amyotrophic lateral sclerosis;Myxofibrosarcoma;Myxoid/round cell liposarcoma. A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3. A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG. The disease may be caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN] Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Li D]] | ||
| + | [[Category: Li X]] | ||
| + | [[Category: Liu C]] | ||
| + | [[Category: Luo F]] | ||
| + | [[Category: Luo Z]] | ||
| + | [[Category: Zhou H]] | ||
Current revision
200kV MicroED structure of FUS (37-42) SYSGYS solved from merged datasets at 0.65 A
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Categories: Homo sapiens | Large Structures | Li D | Li X | Liu C | Luo F | Luo Z | Zhou H
