6kjd
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==lovastatin esterase PcEST inactive mutant S57A in complex with lovastatin== | |
| - | + | <StructureSection load='6kjd' size='340' side='right'caption='[[6kjd]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6kjd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Penicillium_rubens_Wisconsin_54-1255 Penicillium rubens Wisconsin 54-1255]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KJD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.299Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=144:TRIS-HYDROXYMETHYL-METHYL-AMMONIUM'>144</scene>, <scene name='pdbligand=LVA:(3R,5R)-7-((1R,2R,6S,8R,8AS)-2,6-DIMETHYL-8-{[(2R)-2-METHYLBUTANOYL]OXY}-1,2,6,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL)-3,5-DIHYDROXYHEPTANOIC+ACID'>LVA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kjd OCA], [https://pdbe.org/6kjd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kjd RCSB], [https://www.ebi.ac.uk/pdbsum/6kjd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kjd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PCEST_PENRW PCEST_PENRW] Esterase that can hydrolyze the side chain of lovastatin to produce monacolin J (PubMed:28619444, PubMed:31839596). Is also able to hydrolyze the side chains of mevastatin and pravastatin, but not simvastatin (PubMed:28619444).<ref>PMID:28619444</ref> <ref>PMID:31839596</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Penicillium rubens Wisconsin 54-1255]] | ||
| + | [[Category: Liang YJ]] | ||
| + | [[Category: Lu XF]] | ||
Current revision
lovastatin esterase PcEST inactive mutant S57A in complex with lovastatin
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