6pv9
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6pv9 is ON HOLD Authors: Appleby, T.C., Lad, L., Gross, M.L. Description: Human PD-L1 bound to a macrocyclic peptide which blocks the PD-1/PD-L1 in...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Human PD-L1 bound to a macrocyclic peptide which blocks the PD-1/PD-L1 interaction== | |
| - | + | <StructureSection load='6pv9' size='340' side='right'caption='[[6pv9]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6pv9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PV9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9KK:N-methyl+norleucine'>9KK</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=MAA:N-METHYL-L-ALANINE'>MAA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pv9 OCA], [https://pdbe.org/6pv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pv9 RCSB], [https://www.ebi.ac.uk/pdbsum/6pv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pv9 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Gross | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Appleby TC]] | ||
| + | [[Category: Gross ML]] | ||
| + | [[Category: Lad L]] | ||
Current revision
Human PD-L1 bound to a macrocyclic peptide which blocks the PD-1/PD-L1 interaction
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