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6pww

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'''Unreleased structure'''
 
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The entry 6pww is ON HOLD
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==Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome==
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<SX load='6pww' size='340' side='right' viewer='molstar' caption='[[6pww]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6pww]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PWW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pww OCA], [https://pdbe.org/6pww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pww RCSB], [https://www.ebi.ac.uk/pdbsum/6pww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pww ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RBBP5_HUMAN RBBP5_HUMAN] In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.<ref>PMID:19556245</ref>
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Authors:
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
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Description:
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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[[Category: Unreleased Structures]]
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*[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]]
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Xenopus laevis]]
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[[Category: Ayoub A]]
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[[Category: Cho U]]
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[[Category: Cianfrocco MA]]
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[[Category: Dou Y]]
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[[Category: Lee YT]]
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[[Category: Park SH]]
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[[Category: Su M]]
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[[Category: Xu J]]
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[[Category: Zhang B]]
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[[Category: Zhang W]]
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[[Category: Zhang Y]]

Current revision

Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome

6pww, resolution 4.40Å

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OCA

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