6pik

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==Tetrameric cryo-EM ArnA==
==Tetrameric cryo-EM ArnA==
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<StructureSection load='6pik' size='340' side='right'caption='[[6pik]], [[Resolution|resolution]] 7.80&Aring;' scene=''>
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<SX load='6pik' size='340' side='right' viewer='molstar' caption='[[6pik]], [[Resolution|resolution]] 7.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pik]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PIK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pik]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_DH5alpha Escherichia coli DH5alpha]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PIK FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pik OCA], [http://pdbe.org/6pik PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pik RCSB], [http://www.ebi.ac.uk/pdbsum/6pik PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pik ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pik OCA], [https://pdbe.org/6pik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pik RCSB], [https://www.ebi.ac.uk/pdbsum/6pik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pik ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A3W2RQG2_ECOLX A0A3W2RQG2_ECOLX]] Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.[HAMAP-Rule:MF_01166][SAAS:SAAS01095241] [[http://www.uniprot.org/uniprot/A0A479JW67_ECOLX A0A479JW67_ECOLX]] Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.[HAMAP-Rule:MF_01166][SAAS:SAAS01095241]
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[https://www.uniprot.org/uniprot/ARNA_ECOLI ARNA_ECOLI] Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.<ref>PMID:11706007</ref> <ref>PMID:15695810</ref>
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== References ==
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<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gehring, K]]
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[[Category: Gehring K]]
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[[Category: Yang, M]]
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[[Category: Yang M]]
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[[Category: Antibiotic]]
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[[Category: Hexamer]]
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[[Category: Polymyxin resistance]]
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[[Category: Tetramer]]
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Tetrameric cryo-EM ArnA

6pik, resolution 7.80Å

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