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3dg1

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<StructureSection load='3dg1' size='340' side='right'caption='[[3dg1]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
<StructureSection load='3dg1' size='340' side='right'caption='[[3dg1]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3dg1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DG1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3dg1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DG1 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yjo|1yjo]], [[2omm|2omm]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dg1 OCA], [http://pdbe.org/3dg1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dg1 RCSB], [http://www.ebi.ac.uk/pdbsum/3dg1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dg1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dg1 OCA], [https://pdbe.org/3dg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dg1 RCSB], [https://www.ebi.ac.uk/pdbsum/3dg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dg1 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/IAPP_HUMAN IAPP_HUMAN] Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
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Human Islet Amyloid Polypeptide (IAPP or amylin) is a 37-residue hormone found as fibrillar deposits in pancreatic extracts of nearly all type II diabetics. Although the cellular toxicity of IAPP has been established, the structure of the fibrillar form found in these deposits is unknown. Here we have crystallized two segments from IAPP, which themselves form amyloid-like fibrils. The atomic structures of these two segments, NNFGAIL and SSTNVG were determined and form the basis of a model for the most commonly observed, full-length IAPP polymorph.
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Atomic structure of the cross-{beta} spine of Islet Amyloid Polypeptide (Amylin).,Wiltzius JJ, Sievers SA, Sawaya MR, Cascio D, Popov D, Riekel C, Eisenberg D Protein Sci. 2008 Jun 12;. PMID:18556473<ref>PMID:18556473</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3dg1" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cascio, D]]
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[[Category: Cascio D]]
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[[Category: Eisenberg, D]]
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[[Category: Eisenberg D]]
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[[Category: Sawaya, M R]]
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[[Category: Sawaya MR]]
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[[Category: Sievers, S A]]
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[[Category: Sievers SA]]
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[[Category: Wiltzius, J J]]
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[[Category: Wiltzius JJ]]
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[[Category: Amyloid]]
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[[Category: Iapp]]
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[[Category: Protein fibril]]
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[[Category: Sstnvg]]
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[[Category: Steric zipper]]
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Current revision

Segment SSTNVG derived from IAPP

PDB ID 3dg1

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