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Histone methyltransferase 3D structures

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(New page: == 3D Structures of histone methyltransferase == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *DOT1L histone m...)
Current revision (08:21, 22 May 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 12: Line 12:
**[[2igq]] – hHMT-1 C terminal
**[[2igq]] – hHMT-1 C terminal
-
*Histone-lysine N-methyltransferase
+
*Histone-lysine N-methyltransferase; Domains – Tudor 190-410; CxxC or zinc finger 1146-1214
**[[3s8s]] – hKHMT SETD1A RRM domain<br />
**[[3s8s]] – hKHMT SETD1A RRM domain<br />
**[[2mdc]], [[2mdj]] - hKHMT SETD2 WW domain - NMR<br />
**[[2mdc]], [[2mdj]] - hKHMT SETD2 WW domain - NMR<br />
**[[2mdi]] - hKHMT SETD2 WW domain (mutant) - NMR<br />
**[[2mdi]] - hKHMT SETD2 WW domain (mutant) - NMR<br />
-
**[[5kh6]] - hKHMT SETDB1 tudor domain <br />
+
**[[3dlm]], [[5kh6]] - hKHMT SETDB1 tudor domain <br />
**[[5tfp]] - hKHMT SETDB2 N-terminal <br />
**[[5tfp]] - hKHMT SETDB2 N-terminal <br />
**[[2r3a]] – hKHMT Suv39H2<br />
**[[2r3a]] – hKHMT Suv39H2<br />
Line 25: Line 25:
**[[1h3i]] - hKHMT SET7/9 residues 52-344<br />
**[[1h3i]] - hKHMT SET7/9 residues 52-344<br />
**[[2o8j]] - hKHMT H3K9 residues 913-1193<br />
**[[2o8j]] - hKHMT H3K9 residues 913-1193<br />
 +
**[[2j2s]] – Mll1 CxxC domain - NMR<br />
**[[5f5e]] – Mll1 residues 3813-3969<br />
**[[5f5e]] – Mll1 residues 3813-3969<br />
**[[5f59]] – Mll3 residues 4757-4910<br />
**[[5f59]] – Mll3 residues 4757-4910<br />
Line 38: Line 39:
**[[3bo5]] – hKHMT Setmar methyltransferase domain <br />
**[[3bo5]] – hKHMT Setmar methyltransferase domain <br />
**[[3k9j]], [[3k9k]] – hKHMT Setmar transposable domain (mutant)<br />
**[[3k9j]], [[3k9k]] – hKHMT Setmar transposable domain (mutant)<br />
-
**[[3dlm]] - hKHMT Setmdb1 Tudor domain <br />
 
**[[3n71]] - hKHMT Smyd1<br />
**[[3n71]] - hKHMT Smyd1<br />
**[[5hi7]] - hKHMT Smyd3<br />
**[[5hi7]] - hKHMT Smyd3<br />
Line 47: Line 47:
**[[4mi5]] – hKHMT Ezh2 SET domain<br />
**[[4mi5]] – hKHMT Ezh2 SET domain<br />
**[[6by9]] - hKHMT EHMT1 residues 672-999<br />
**[[6by9]] - hKHMT EHMT1 residues 672-999<br />
 +
**[[6mm1]] - hKHMT EHMT2 Cys-rich domain residues 419-552<br />
**[[5v2n]] - hKHMT KMT5A residues 231-393<br />
**[[5v2n]] - hKHMT KMT5A residues 231-393<br />
 +
**[[6xau]] – mKHMT Prdm3 PR domain - mouse<br />
**[[2j8a]] – KHMT SET1 RRM domain – yeast<br />
**[[2j8a]] – KHMT SET1 RRM domain – yeast<br />
**[[1u2z]] – yKHMT C terminal<br />
**[[1u2z]] – yKHMT C terminal<br />
 +
**[[5h6z]], [[5ww0]] - KHMT SET7 – fission yeast <br />
**[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br />
**[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br />
**[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br />
**[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br />
Line 64: Line 67:
**[[5ei9]], [[5eh2]], [[5egb]] - hKHMT Prdm9 zinc finger domain + DNA<br />
**[[5ei9]], [[5eh2]], [[5egb]] - hKHMT Prdm9 zinc finger domain + DNA<br />
**[[4ygi]] – AtKHMT Suvh4 + DNA<br />
**[[4ygi]] – AtKHMT Suvh4 + DNA<br />
 +
**[[6a5n]] – AtKHMT Suvh6 + DNA<br />
*Histone-lysine N-methyltransferase binary complexes with methyl donor
*Histone-lysine N-methyltransferase binary complexes with methyl donor
Line 73: Line 77:
**[[4h12]], [[5jle]] – hKHMT SETD2 catalytic domain + SAH <br />
**[[4h12]], [[5jle]] – hKHMT SETD2 catalytic domain + SAH <br />
**[[3smt]] – hKHMT SETD3 + SAM <br />
**[[3smt]] – hKHMT SETD3 + SAM <br />
-
**[[4bup]], [[3ooi]] – hKHMT SET domain + SAM <br />
+
**[[3ooi]], [[6kqp]] - hKHMT Nsd1 SET domain residues 1864-2083 + SAM<br />
**[[3qox]], [[3sx0]] – hKHMT + SAH <br />
**[[3qox]], [[3sx0]] – hKHMT + SAH <br />
**[[2w5y]] – hKHMT Hrx methyltransferase domain + SAH <br />
**[[2w5y]] – hKHMT Hrx methyltransferase domain + SAH <br />
-
**[[3rib]] – hKHMT Smyd2 + SAH<br />
+
**[[3rib]], [[6n3g]] – hKHMT Smyd2 + SAH<br />
**[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br />
**[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br />
**[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br />
**[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br />
**[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br />
**[[1n6a]] – hKHMT SET7/9 SET domain + SAM<br />
**[[1n6c]] – hKHMT SET7/9 residues 70-366 + SAM<br />
**[[1n6c]] – hKHMT SET7/9 residues 70-366 + SAM<br />
 +
**[[4bup]] – mKHMT SET domain 70-336 + SAM <br />
 +
**[[6a5k]], [[6a5m]] – AtKHMT Suvh6 + SAM<br />
*Histone-lysine N-methyltransferase binary complexes with inhibitor
*Histone-lysine N-methyltransferase binary complexes with inhibitor
Line 88: Line 94:
**[[5th7]] – hKHMT SETD8 + inhibitor <br />
**[[5th7]] – hKHMT SETD8 + inhibitor <br />
**[[5t5g]] – hKHMT SETD8 (mutant) + inhibitor <br />
**[[5t5g]] – hKHMT SETD8 (mutant) + inhibitor <br />
-
**[[5ke3]], [[5ke2]], [[5kco]], [[5kch]], [[6bpi]], [[6au3]], [[6au2]] - hKHMT SETDB1 tudor domain + inhibitor<br />
+
**[[5ke3]], [[5ke2]], [[5kco]], [[5kch]], [[6bpi]], [[6au3]], [[6au2]], [[7c9n]], [[7caj]], [[7cd9]], [[7cjt]] - hKHMT SETDB1 tudor domain + inhibitor<br />
**[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br />
**[[3sr4]], [[3uwp]], [[4ek9]], [[4ekg]], [[4eki]], [[4eqz]], [[4er0]], [[4er3]], [[4er5]], [[4er6]], [[4er7]], [[4hra]] - hKHMT catalytic domain + inhibitor<br />
**[[4wuy]], [[6cby]], [[6cbx]], [[5wcg]] - hKHMT Smyd2 + inhibitor<br />
**[[4wuy]], [[6cby]], [[6cbx]], [[5wcg]] - hKHMT Smyd2 + inhibitor<br />
Line 98: Line 104:
**[[5vse]], [[5vsc]], [[5vpi]] - hKHMT EHMT2 SET domain + inhibitor<br />
**[[5vse]], [[5vsc]], [[5vpi]] - hKHMT EHMT2 SET domain + inhibitor<br />
**[[6nm4]] - hKHMT Prdm9 zinc finger domain + inhibitor<br />
**[[6nm4]] - hKHMT Prdm9 zinc finger domain + inhibitor<br />
 +
**[[6ue6]], [[6xcg]] - hKHMT Nsd2 PWWP1 domain residues 211-350 + inhibitor<br />
**[[6g2o]], [[6g2f]], [[6g2e]], [[6g2c]], [[6g2b]], [[6g29]], [[6g27]], [[6g25]], [[6g24]] - hKHMT Nsd3 residues 247-398 + inhibitor<br />
**[[6g2o]], [[6g2f]], [[6g2e]], [[6g2c]], [[6g2b]], [[6g29]], [[6g27]], [[6g25]], [[6g24]] - hKHMT Nsd3 residues 247-398 + inhibitor<br />
 +
**[[6u9k]], [[6u9m]], [[6u9n]], [[6u9r]] - hKHMT MLL1 SET 167-333 (mutant) + inhibitor<br />
*Histone-lysine N-methyltransferase binary complexes with polypeptide
*Histone-lysine N-methyltransferase binary complexes with polypeptide
Line 105: Line 113:
**[[3sw9]], [[3swc]] – hKHMT SET domain + peptide<br />
**[[3sw9]], [[3swc]] – hKHMT SET domain + peptide<br />
**[[4gne]], [[4gnf]], [[4gng]] - hKHMT Nsd3 Phd5-C5HCH + H3 peptide<br />
**[[4gne]], [[4gnf]], [[4gng]] - hKHMT Nsd3 Phd5-C5HCH + H3 peptide<br />
-
**[[6cen]] - hKHMT Nsd3 + inhibitor peptide<br />
 
-
**[[6mon]] - hKHMT Smyd2 + inhibitor peptide<br />
 
**[[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br />
**[[3b95]] - hKHMT ankyrin repeat domain + H3 peptide<br />
**[[6bhi]], [[6bhh]], [[6bhg]], [[6bhe]], [[6bhd]] - hKHMT SETDB1 tudor domain + H3 peptide<br />
**[[6bhi]], [[6bhh]], [[6bhg]], [[6bhe]], [[6bhd]] - hKHMT SETDB1 tudor domain + H3 peptide<br />
Line 114: Line 120:
**[[5ex3]], [[5ex0]] - hKHMT Smyd3 + peptide<br />
**[[5ex3]], [[5ex0]] - hKHMT Smyd3 + peptide<br />
**[[5yvx]] - hKHMT Ashh2 CW domain + H3 peptide<br />
**[[5yvx]] - hKHMT Ashh2 CW domain + H3 peptide<br />
-
**[[6hbo]] - hKHMT Ashh2 CW domain + H3 peptide - NMR<br />
+
**[[6qxz]] - hKHMT Ashh2 CW domain + H3 peptide - NMR<br />
**[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br />
**[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br />
**[[6cko]] - zKHMT + AF-10 - zebrafish<br />
**[[6cko]] - zKHMT + AF-10 - zebrafish<br />
Line 123: Line 129:
**[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br />
**[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br />
**[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br />
**[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br />
-
**[[6e2h]] – hKHMT SET/Ash2 + DPY-30L <br />
+
**[[4riq]], [[6e2h]] – hKHMT SET/Ash2 + DPY-30L <br />
 +
**[[6u4y]] - hKHMT Ezh2 + polycomb protein EED<br />
 +
**[[6jn2]] – hKHMT4 coiled-coil domain 470-550 + AF-10<br />
*Histone-lysine N-methyltransferase ternary complex containing polypeptide
*Histone-lysine N-methyltransferase ternary complex containing polypeptide
**[[2w5z]] – hKHMT Hrx methyltransferase domain + SAH + histone peptide<br />
**[[2w5z]] – hKHMT Hrx methyltransferase domain + SAH + histone peptide<br />
-
**[[5v22]], [[5v21]], [[5jlb]], [[5jjy]] - hKHMT SETD2 SET domain + SAH + H3 peptide<br />
+
**[[5v22]], [[5v21]], [[5jlb]], [[5jjy]] - hKHMT SETD2 catalytic domain 1434-1711 + SAH + H3 peptide<br />
 +
**[[6vdb]] - hKHMT SETD2 catalytic domain + SAH + peptide<br />
 +
**[[6jat]], [[6ox0]], [[6ox1]], [[6ox2]], [[6ox3]], [[6ox4]], [[6ox5]] - hKHMT SETD3 + sinefungin + actin peptide<br />
 +
**[[6v63]], [[6wk1]], [[6wk2]] - hKHMT SETD3 + SAH + actin peptide<br />
 +
**[[6v62]] - hKHMT SETD3 (mutant) + SAH + actin peptide<br />
**[[1o9s]] - hKHMT SET7/9 SET domain + SAH + H3 peptide<br />
**[[1o9s]] - hKHMT SET7/9 SET domain + SAH + H3 peptide<br />
**[[2bqz]] - hKHMT SET7 SET domain + SAH + H4 peptide<br />
**[[2bqz]] - hKHMT SET7 SET domain + SAH + H4 peptide<br />
Line 149: Line 161:
**[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br />
**[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br />
**[[5v3h]] – hKHMT Smyd2 (mutant) + SAM + inhibitor<br />
**[[5v3h]] – hKHMT Smyd2 (mutant) + SAM + inhibitor<br />
-
**[[5v37]] – hKHMT Smyd3 + SAM + inhibitor<br />
+
**[[5v37]], [[6p6k]], [[6p7z]], [[6paf]] – hKHMT Smyd3 + SAM + inhibitor<br />
 +
**[[6o9o]], [[6p6g]] – hKHMT Smyd3 + SAH + inhibitor<br />
**[[5hq8]] – hKHMT Smyd3 + SAH + MEKK2 peptide<br />
**[[5hq8]] – hKHMT Smyd3 + SAH + MEKK2 peptide<br />
**[[6ine]], [[6ago]] – hKHMT Ash1L + MRG15 + SAM <br />
**[[6ine]], [[6ago]] – hKHMT Ash1L + MRG15 + SAM <br />
Line 155: Line 168:
**[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br />
**[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br />
**[[4i51]] - hKHMT (mutant) + SAH + H3 peptide <br />
**[[4i51]] - hKHMT (mutant) + SAH + H3 peptide <br />
-
**[[5f6l]] – hKHMT Mll1 (mutant) + RBBP5 + Ash2L<br />
+
**[[6cen]] - hKHMT Nsd3 + inhibitor peptide + SAM<br />
 +
**[[7bre]] – hKHMT Mll1 + RBBP5 + Ash2L<br />
 +
**[[5f6l]], [[7w67]], [[7w6a]], [[7w6i]], [[7w6j]] – hKHMT Mll1 (mutant) + RBBP5 + Ash2L<br />
**[[5f6k]] – hKHMT Mll3 + RBBP5 + Ash2L + peptide<br />
**[[5f6k]] – hKHMT Mll3 + RBBP5 + Ash2L + peptide<br />
**[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br />
**[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br />
**[[2g46]] – PvKHMT + SAH + H3 peptide<br />
**[[2g46]] – PvKHMT + SAH + H3 peptide<br />
-
**[[4au7]] - mKHMT + SAH + H4 peptide - mouse<br />
+
**[[4au7]] - mKHMT + SAH + H4 peptide<br />
*Histone-lysine N-methyltransferase ternary complex containing inhibitor; Domains – catalytic 879-1159; SET 1006-1266
*Histone-lysine N-methyltransferase ternary complex containing inhibitor; Domains – catalytic 879-1159; SET 1006-1266
Line 166: Line 181:
**[[5ylt]] - hKHMT SET7/9 SET domain + sinefungin + inhibitor<br />
**[[5ylt]] - hKHMT SET7/9 SET domain + sinefungin + inhibitor<br />
**[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br />
**[[3fpd]], [[3k5k]], [[3mo0]], [[3mo2]], [[3mo5]], [[3rjw]], [[4nvq]] - hKHMT SET domain + SAH + inhibitor<br />
 +
**[[7lzb]], [[7lzd]], [[7lzf]] - hKHMT SETD2 catalytic domain 1434-1711 + SAH + inhibitor<br />
**[[5tuz]], [[6mbp]], [[6mbo]] - hKHMT EHMT1 SET domain + SAH + inhibitor<br />
**[[5tuz]], [[6mbp]], [[6mbo]] - hKHMT EHMT1 SET domain + SAH + inhibitor<br />
**[[5ttg]], [[5v9j]] - hKHMT EHMT1 catalytic domain + SAM + inhibitor<br />
**[[5ttg]], [[5v9j]] - hKHMT EHMT1 catalytic domain + SAM + inhibitor<br />
-
**[[5tuy]], [[5v9i]] - hKHMT EHMT2 SET domain + SAM + inhibitor<br />
+
**[[5tuy]], [[5v9i]], [[7btv]], [[7buc]], [[7dcf]] - hKHMT EHMT2 SET domain + SAM + inhibitor<br />
**[[5ttf]] - hKHMT EHMT2 catalytic domain + SAM + inhibitor<br />
**[[5ttf]] - hKHMT EHMT2 catalytic domain + SAM + inhibitor<br />
**[[3s7b]], [[5kjn]], [[5kjm]], [[5kjl]], [[5kjk]], [[5arg]], [[5arf]], [[4ynd]] - hKHMT Smyd2 + SAM + inhibitor<br />
**[[3s7b]], [[5kjn]], [[5kjm]], [[5kjl]], [[5kjk]], [[5arg]], [[5arf]], [[4ynd]] - hKHMT Smyd2 + SAM + inhibitor<br />
-
**[[5ccm]], [[5ccl]], [[5yjo]], [[5xxj]], [[5xxg]], [[5xxd]] – hKHMT Smyd3 + SAM + inhibitor<br />
+
**[[6mon]] - hKHMT Smyd2 + SAH + inhibitor peptide<br />
 +
**[[5ccm]], [[5ccl]], [[5yjo]], [[5xxj]], [[5xxg]], [[5xxd]], [[6ijl]] – hKHMT Smyd3 + SAM + inhibitor<br />
**[[1zkk]] - hKHMT + SAH + H4 peptide <br />
**[[1zkk]] - hKHMT + SAH + H4 peptide <br />
 +
**[[6in3]] – hKHMT DOT1L + SAH + inhibitor <br />
 +
**[[6kqq]] - hKHMT Nsd1 SET domain residues 1864-2083 + SAM + inhibitor<br />
 +
**[[6nm4]] - hKHMT Prdm9 zinc finger domain + inhibitor + SAM<br />
 +
**[[6wzw]] – hKHMT Ash1L SET domain 2074-2293 + inhibitor + SAM <br />
 +
**[[6x0p]] – hKHMT Ash1L SET domain 2074-2293 (mutant) + inhibitor + SAM <br />
 +
**[[6w5i]], [[6w5m]], [[6w5n]] – hKHMT Ash2L in nucleosome – Cryo EM<br />
 +
**[[7ea8]] – hKHMT Setd2 in nucleosome – Cryo EM<br />
**[[4qen]], [[4qeo]], [[4qep]] – AtKHMT Suvh4 + DNA + SAH<br />
**[[4qen]], [[4qeo]], [[4qep]] – AtKHMT Suvh4 + DNA + SAH<br />
Line 179: Line 203:
**[[5hq2]] - hKHMT SETD8 SET domain + H3 + H4 + H2 + SRM1 + DNA<br />
**[[5hq2]] - hKHMT SETD8 SET domain + H3 + H4 + H2 + SRM1 + DNA<br />
**[[6jm9]] - hKHMT DOT1 + H3.2 + H4 + H2A + H2B + DNA – Cryo EM<br />
**[[6jm9]] - hKHMT DOT1 + H3.2 + H4 + H2A + H2B + DNA – Cryo EM<br />
-
**[[6o96]], [[6nqa]], [[6nog]], [[6nn6]], [[6nj9]], [[6jma]], [[6j99]] - hKHMT DOT1 + H3.2 + H4 + H2A + H2B + polyubiquitin + DNA – Cryo EM<br />
+
**[[6o96]], [[6nqa]], [[6nog]], [[6nn6]], [[6nj9]], [[6jm9]], [[6jma]], [[6j99]], [[7bwd]], [[7k6p]], [[7k6q]] - hKHMT DOT1 in nucleosome – Cryo EM<br />
 +
**[[7cro]] - hKHMT Nsd2 in nucleosome – Cryo EM<br />
 +
**[[7crr]] - hKHMT Nsd3 in nucleosome – Cryo EM<br />
 +
**[[7crp]], [[7crq]] - hKHMT Nsd3 (mutant) in nucleosome – Cryo EM<br />
 +
**[[6w5i]], [[6w5m]], [[6w5n]] – hKHMT Ash2L in nucleosome – Cryo EM<br />
 +
**[[7xpx]] – hKHMT SET8 in nucleosome – Cryo EM<br />
 +
**[[7mbm]], [[7mbn]], [[7ud5]] – hKHMT MLL1 in nucleosome – Cryo EM<br />
**[[5t0m]], [[5t0k]] - hKHMT EHMT2 SET domain + SAM + SAH + H3 peptide<br />
**[[5t0m]], [[5t0k]] - hKHMT EHMT2 SET domain + SAM + SAH + H3 peptide<br />
-
**[[5ls6]], [[5hyn]] - hKHMT Ezh2 + polycomb protein + Jarid2 + inhibitor<br />
+
**[[5ls6]], [[5hyn]] - hKHMT Ezh2in+ polycomb complex + inhibitor<br />
-
**[[6c24]], [[6c23]] - hKHMT Ezh2 + polycomb repressor complex 2 – Cryo EM<br />
+
**[[6c24]], [[6c23]], [[6wkr]] - hKHMT Ezh2 in polycomb complex – Cryo EM<br />
 +
**[[7kso]], [[7ktp]], [[7ksr]] - hKHMT Ezh1 in polycomb complex – Cryo EM<br />
 +
**[[6pwv]] - hKHMT 2A + MLL1 complex – Cryo EM<br />
 +
**[[6pww]] - hKHMT 2A + MLL1 complex + RBPP5 + WDR5 – Cryo EM<br />
 +
**[[6kiu]], [[6kiv]] - hKHMT 2A + MLL1-UBNCP complex – Cryo EM<br />
 +
**[[6kiw]] - hKHMT 2A + MLL3-UBNCP complex – Cryo EM<br />
 +
**[[6kix]], [[6kiz]] - hKHMT 2A + MLL1-NCP complex – Cryo EM<br />
 +
**[[6nzo]], [[6px3]], [[6ugm]], [[6uh5]] - fKHMT in nucleosome – frog – Cryo EM<br />
 +
**[[6uh5]] - fKHMT in nucleosome + ubiquitin – Cryo EM<br />
 +
**[[6ven]] - yKHMT 762-1080 in compass complex – Cryo EM<br />
 +
**[[7ea5]] - yKHMT in nucleosome – Cryo EM<br />
*Histone-arginine N-methyltransferase (Carm1)
*Histone-arginine N-methyltransferase (Carm1)
Line 189: Line 229:
**[[4hc4]] – hPRMT6 (mutant)<br />
**[[4hc4]] – hPRMT6 (mutant)<br />
**[[2v74]], [[2v7e]] – mPRMT catalytic domain <br />
**[[2v74]], [[2v7e]] – mPRMT catalytic domain <br />
-
**[[4c03]], [[4c06]], [[4c07]], [[4c08]], [[5hzm]] – mPRMT6<br />
+
**[[4c03]], [[4c06]], [[4c07]], [[4c08]], [[5hzm]], [[6sqh]], [[6sqi]] – mPRMT6<br />
**[[2obq]] – rPRMT N terminal - rat <br />
**[[2obq]] – rPRMT N terminal - rat <br />
**[[3b3g]], [[3b3j]] – rPRMT catalytic domain <br />
**[[3b3g]], [[3b3j]] – rPRMT catalytic domain <br />
Line 197: Line 237:
**[[5u4x]] – hPRMT1 catalytic domain + SAH<br />
**[[5u4x]] – hPRMT1 catalytic domain + SAH<br />
**[[6nt2]] – hPRMT1 residues 1-371 + inhibitor<br />
**[[6nt2]] – hPRMT1 residues 1-371 + inhibitor<br />
-
**[[5dxj]] – hPRMT4 catalytic domain + sinefungin <br />
+
**[[5dxj]] – hPRMT4 catalytic domain 145-489 + sinefungin <br />
**[[4ikp]], [[6d2l]], [[6dvr]] – hPRMT4 catalytic domain + purine derivative<br />
**[[4ikp]], [[6d2l]], [[6dvr]] – hPRMT4 catalytic domain + purine derivative<br />
 +
**[[6izq]], [[6s70]], [[6s71]], [[6s74]], [[6s77]], [[6s79]], [[6s7a]], [[6s7b]], [[6s7c]], [[6te6]], [[6tel]], [[6ten]] – hPRMT4 catalytic domain + inhibitor<br />
 +
**[[7boc]] – hPRMT5 TIM barrel domain 1-292 + peptide<br />
 +
**[[6ugh]] – hPRMT5 + MEP50 – Cryo EM<br />
**[[5egs]], [[5wcf]], [[5lv5]], [[5lv4]], [[5lv3]], [[5lv2]] – hPRMT6 + inhibitor<br />
**[[5egs]], [[5wcf]], [[5lv5]], [[5lv4]], [[5lv3]], [[5lv2]] – hPRMT6 + inhibitor<br />
 +
**[[5dst]] – hPRMT8 catalytic domain + SAH<br />
**[[5ih3]] – mPRMT4 + SAH<br />
**[[5ih3]] – mPRMT4 + SAH<br />
**[[5k8v]], [[5isi]], [[5ish]], [[5isg]], [[5isf]], [[5ise]], [[5isd]], [[5isc]], [[5isb]], [[5isa]], [[5is9]], [[5is8]], [[5is7]], [[5is6]], [[5tbj]], [[5tbi]], [[5tbh]], [[5ntc]], [[5lkj]], [[5k8x]], [[5k8w]] – mPRMT4 + inhibitor<br />
**[[5k8v]], [[5isi]], [[5ish]], [[5isg]], [[5isf]], [[5ise]], [[5isd]], [[5isc]], [[5isb]], [[5isa]], [[5is9]], [[5is8]], [[5is7]], [[5is6]], [[5tbj]], [[5tbi]], [[5tbh]], [[5ntc]], [[5lkj]], [[5k8x]], [[5k8w]] – mPRMT4 + inhibitor<br />
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mPRMT4 + poly(A)-binding protein peptide + inhibitor<br />
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mPRMT4 + poly(A)-binding protein peptide + inhibitor<br />
-
**[[4c04]] – mPRMT6 + inhibitor<br />
+
**[[4c04]], [[6sq3]], [[6sq4]], [[7nud]], [[7nue]], [[7p2r]], [[7ppq]], [[7ppy]], [[7pu8]], [[7puc]], [[7puq]], [[7pv6]] – mPRMT 6 + inhibitor<br />
 +
**[[6sqk]] – mPRMT 6 + peptide<br />
 +
**[[7os4]] – mPRMT 6 + histone H3.1<br />
 +
**[[7okp]] – mPRMT 6 + histone H3.3<br />
**[[4c05]], [[5fqo]], [[5fqn]] – mPRMT6 + SAH<br />
**[[4c05]], [[5fqo]], [[5fqn]] – mPRMT6 + SAH<br />
**[[4c4a]] – mPRMT7 + SAH<br />
**[[4c4a]] – mPRMT7 + SAH<br />
**[[6ogn]] – mPRMT7 + inhibitor<br />
**[[6ogn]] – mPRMT7 + inhibitor<br />
**[[3b3f]] – rPRMT catalytic domain + SAH<br />
**[[3b3f]] – rPRMT catalytic domain + SAH<br />
 +
**[[6z2a]] – fyPRMT (mutant) + SAH – fission yeast<br />
 +
**[[6bp4]] – fyPRMT catalytic domain + SAH<br />
*Histone-arginine N-methyltransferase (Carm1) ternary complex
*Histone-arginine N-methyltransferase (Carm1) ternary complex
Line 215: Line 264:
**[[2y1w]], [[2y1x]] – hPRMT4 catalytic domain + sinefungin + indole inhibitor<br />
**[[2y1w]], [[2y1x]] – hPRMT4 catalytic domain + sinefungin + indole inhibitor<br />
**[[6arv]], [[6arj]] – hPRMT4 catalytic domain + SAH + inhibitor<br />
**[[6arv]], [[6arj]] – hPRMT4 catalytic domain + SAH + inhibitor<br />
 +
**[[6rll]], [[6rlq]], [[6uxx]], [[6uxy]] – hPRMT5 + MEP50 + inhibitor<br />
 +
**[[7m05]] – hPRMT5 + MEP50 + inhibitor – Cryo EM<br />
 +
**[[6w6d]], [[6wad]], [[7nr4]] – hPRMT6 1-375 + SAH + inhibitor<br />
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mPRMT 4 + poly(A)-binding protein peptide + inhibitor<br />
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mPRMT 4 + poly(A)-binding protein peptide + inhibitor<br />
-
**[[4gqb]], [[5fa5]] – hPRMT5 + methylosome protein 50 + H4 peptide<br />
+
**[[4gqb]], [[5fa5]] – hPRMT5 + MEP50 + H4 peptide<br />
-
**[[5emm]] – hPRMT5 + methylosome protein 50 + sinefungin<br />
+
**[[5emm]] – hPRMT5 + MEP50 + sinefungin<br />
-
**[[6k1s]] – hPRMT5 + methylosome protein 50 + inhibitor<br />
+
**[[6k1s]], [[7kic]] – hPRMT5 + MEP50 + inhibitor<br />
-
**[[5eml]] – hPRMT5 + methylosome protein 50 + SAM<br />
+
**[[5eml]], [[7kib]], [[7l1g]] – hPRMT5 + MEP50 + SAM<br />
-
**[[5emk]], [[5emj]], [[5c9z]] – hPRMT5 + methylosome protein 50 + sinefungin + inhibitor<br />
+
**[[5emk]], [[5emj]], [[5c9z]] – hPRMT5 + MEP50 + sinefungin + inhibitor<br />
-
**[[4x63]], [[4x61]], [[4x60]] – hPRMT5 + methylosome protein 50 + SAH + inhibitor<br />
+
**[[6v0n]], [[6v0o]] – hPRMT5 + MEP50 + sinefungin + peptide<br />
-
**[[6ckc]] – hPRMT5 + methylosome protein 50 + inhibitor<br />
+
**[[4x63]], [[4x61]], [[4x60]] – hPRMT5 + MEP50 + SAH + inhibitor<br />
 +
**[[6ckc]], [[7kid]] – hPRMT5 + MEP50 + inhibitor<br />
**[[5e8r]], [[4y30]], [[4y2h]], [[6p7i]] – hPRMT6 + SAH + inhibitor<br />
**[[5e8r]], [[4y30]], [[4y2h]], [[6p7i]] – hPRMT6 + SAH + inhibitor<br />
**[[4qpp]] – hPRMT6 (mutant) + peptide + inhibitor<br />
**[[4qpp]] – hPRMT6 (mutant) + peptide + inhibitor<br />

Current revision

3D Structures of histone methyltransferase

Updated on 22-May-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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